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Wnt10b Gene Detail
Summary
  • Symbol
    Wnt10b
  • Name
    wingless-type MMTV integration site family, member 10B
  • Synonyms
    Wnt12
  • Feature Type
    protein coding gene
  • IDs
    MGI:108061
    NCBI Gene: 22410
  • Gene Overview
    MyGene.info: WNT10B
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:98770712-98778150 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 54.65 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108061
protein coding gene Chr15:98770712-98778212 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022310
protein coding gene Chr15:100529403-100535765 (-)
A/J MGP_AJ_G0022268
protein coding gene Chr15:96559638-96566004 (-)
AKR/J MGP_AKRJ_G0022243
protein coding gene Chr15:99532984-99539346 (-)
BALB/cJ MGP_BALBcJ_G0022275
protein coding gene Chr15:96753186-96759582 (-)
C3H/HeJ MGP_C3HHeJ_G0022043
protein coding gene Chr15:99584483-99590849 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022720
protein coding gene Chr15:104262999-104269456 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020245
protein coding gene Chr15:92476990-92483470 (-)
CAST/EiJ MGP_CASTEiJ_G0021566
protein coding gene Chr15:100427263-100434271 (-)
CBA/J MGP_CBAJ_G0022012
protein coding gene Chr15:107806347-107812736 (-)
DBA/2J MGP_DBA2J_G0022138
protein coding gene Chr15:96002490-96008882 (-)
FVB/NJ MGP_FVBNJ_G0022118
protein coding gene Chr15:94980972-94987363 (-)
LP/J MGP_LPJ_G0022210
protein coding gene Chr15:100679981-100686345 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022138
protein coding gene Chr15:111806008-111812410 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022735
protein coding gene Chr15:99613596-99619986 (-)
PWK/PhJ MGP_PWKPhJ_G0021307
protein coding gene Chr15:96123571-96130048 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021142
protein coding gene Chr15:99458623-99464992 (-)
WSB/EiJ MGP_WSBEiJ_G0021616
protein coding gene Chr15:100162688-100168703 (-)



Homology
more
  • Human Ortholog
    WNT10B, Wnt family member 10B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    WNT10B, Wnt family member 10B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SHFM6, STHAG8, WNT-12
  • Links
    NCBI Gene ID: 7480
    neXtProt AC: NX_O00744
    UniProt: O00744

  • Chr Location
    12q13.12; chr12:48965340-48971858 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human WNT10B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022996 Ensembl Gene Model | MGI Sequence Detail 7439 C57BL/6J ±  kb
    transcript ENSMUST00000226610 Ensembl | MGI Sequence Detail 2217 Not Applicable  
    polypeptide ENSMUSP00000153817 Ensembl | MGI Sequence Detail 389 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 4
      cDNA 26
      Primer pair 13
      Other 7

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-18790, MGD-MRK-37098
    References
    more
    • Summaries
      All 186
      Developmental Gene Expression 111
      Diseases 1
      Gene Ontology 19
      Phenotypes 35
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:250512 Li J, et al., CITGeneDB: a comprehensive database of human and mouse genes enhancing or suppressing cold-induced thermogenesis validated by perturbation experiments in mice. Database (Oxford). 2018;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory