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Wnt10b
Gene Detail
Symbol

Name
ID
Wnt10b
wingless-type MMTV integration site family, member 10B
MGI:108061
Synonyms
Wnt12
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:98771753-98778150 bp, - strand
From Ensembl annotation of GRCm38

  6398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT10B
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt10b

Human
homologs
WNT10B, wingless-type MMTV integration site family, member 10B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7480
neXtProt AC: NX_O00744

Human Synonyms: SHFM6, WNT-12

Human Chr (Location): 12q13; chr12:48965340-48971858 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human WNT10B

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Wnt10b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle.
 
Phenotype Images(2)
Interactions
Wnt10b interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process bone trabecula formation, canonical Wnt signaling pathway, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (96 records)
Data Summary: Results (750)    Tissues (513)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 636
Northern blot 72
RT-PCR 31
RNase protection 6
cDNA source data(21)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase wnt10b ; ZFIN wnt10b    NEW 
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(25) Primer pair(13) Other(5)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000022996 (Evidence)
Entrez Gene 22410 (Evidence)
UniGene 4709
DFCI TC1589662, TC1624423
DoTS DT.101340062, DT.55140088, DT.87039266, DT.87050049
NIA Mouse Gene Index U036631
Consensus CDS Project CCDS27806.1
International Mouse Phenotyping Consortium Status Wnt10b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022996 Ensembl Gene Model | MGI Sequence Detail 6398 C57BL/6J ±  kb
transcript ENSMUST00000023732 Ensembl | MGI Sequence Detail 2226 Not Applicable 
polypeptide ENSMUSP00000023732 Ensembl | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(8) UniProt(2)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013302 Wnt-10 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017437 protein Wnt-10b
References
(Earliest) J:21464 Adamson MC, et al., Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994 Nov 1;24(1):9-13
(Latest) J:217590 Yuan G, et al., The non-canonical BMP and Wnt/beta-catenin signaling pathways orchestrate early tooth development. Development. 2015 Jan 1;142(1):128-39
All references(140)
Other
accession IDs
MGD-MRK-18790, MGD-MRK-37098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory