Wnt10b
Gene Detail

Symbol Name ID

Wnt10b wingless related MMTV integration site 10b MGI:108061

Synonyms

Wnt12

Feature Type

protein coding gene

Genetic Map

Chromosome 15

54.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr15:98771753-98778150 bp, - strand From Ensembl annotation of GRCm38   6398 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt10b

Human homologs

Human Homolog		WNT10B, wingless-type MMTV integration site family, member 10b
NCBI Gene ID		7480
neXtProt AC		NX_O00744
Human Synonyms		SHFM6, WNT-12
Human Chr (Location)		12q13; chr12:49359123-49365641 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human WNT10B

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	bone trabecula formation, canonical Wnt receptor signaling pathway, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, receptor binding

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (89 records)
Data Summary: Results (375)    Tissues (278)    Images (90)
Theiler Stages: 1, 2, 3, 4, 5, 8, 9, 10, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	255
Northern blot	72
RT-PCR	37
RNase protection	6

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(4) cDNA(24) Primer pair(13) Other(5)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000022996 (Evidence)
Entrez Gene	22410 (Evidence)
UniGene	4709
DFCI	TC1589662, TC1624423
DoTS	DT.101340062, DT.55140088, DT.87039266, DT.87050049
NIA Mouse Gene Index	U036631
Consensus CDS Project	CCDS27806.1
International Mouse Knockout Project Status	Wnt10b

Sequences

Length	Strain/Species
genomic	ENSMUSG00000022996	Ensembl Gene Model | MGI Sequence Detail	6398	C57BL/6J
transcript	ENSMUST00000023732	Ensembl | MGI Sequence Detail	2226	Not Applicable
polypeptide	ENSMUSP00000023732	Ensembl | MGI Sequence Detail	389	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(12 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013302	Wnt-10 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017437	protein Wnt-10b

References

(Earliest) J:21464 Adamson MC, et al., Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994 Nov 1;24(1):9-13
(Latest) J:194074 Ahn Y, et al., Lrp4 and Wise interplay controls the formation and patterning of mammary and other skin appendage placodes by modulating Wnt signaling. Development. 2013 Feb 1;140(3):583-93
All references(132)

Other accession IDs

MGD-MRK-18790, MGD-MRK-37098