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Wnt10b
Gene Detail
Symbol

Name
ID
Wnt10b
wingless-type MMTV integration site family, member 10B
MGI:108061
Synonyms
Wnt12
Feature Type
protein coding gene
Genetic Map
Chromosome 15
54.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr15:98771753-98778150 bp, - strand
From Ensembl annotation of GRCm38

  6398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20721  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt10b

Human
homologs
Human Homolog WNT10B, wingless-type MMTV integration site family, member 10b
NCBI Gene ID 7480
neXtProt AC  NX_O00744
Human Synonyms  SHFM6, WNT-12
Human Chr (Location)  12q13; chr12:48965340-48971858 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human WNT10B
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Radiation induced(1) Targeted(4)
Genomic Mutations involving Wnt10b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant mice fed a low- or high-fat diet exhibit accelerated myogenic differentiation of myoblasts and those fed a high-fat diet exhibit excessive lipid accumulation in actively regenerating muscle.
 
Interactions
Wnt10b interacts with 93 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process bone trabecula formation, canonical Wnt signaling pathway, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, receptor binding
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (94 records)
Data Summary: Results (749)    Tissues (512)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 635
Northern blot 72
RT-PCR 31
RNase protection 6
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(47) Genomic(4) cDNA(25) Primer pair(13) Other(5)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000022996 (Evidence)
Entrez Gene22410 (Evidence)
UniGene4709
DFCITC1624423, TC1589662
DoTSDT.101340062, DT.87050049, DT.87039266, DT.55140088
NIA Mouse Gene IndexU036631
Consensus CDS ProjectCCDS27806.1
International Mouse Knockout Project StatusWnt10b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022996 Ensembl Gene Model | MGI Sequence Detail 6398 C57BL/6J ±  kb
transcript ENSMUST00000166022 Ensembl | MGI Sequence Detail 1594 Not Applicable 
polypeptide ENSMUSP00000131056 Ensembl | MGI Sequence Detail 389 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(3)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(22 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013302 Wnt-10 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017437 protein Wnt-10b
References
(Earliest) J:21464 Adamson MC, et al., Isolation and genetic mapping of two novel members of the murine Wnt gene family, Wnt11 and Wnt12, and the mapping of Wnt5a and Wnt7a. Genomics. 1994 Nov 1;24(1):9-13
(Latest) J:207612 Zhang L, et al., Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. Dev Biol. 2014 Mar 1;387(1):64-72
All references(139)
Other
accession IDs
MGD-MRK-18790, MGD-MRK-37098

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory