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Adm
Gene Detail
Symbol

Name
ID
Adm
adrenomedullin
MGI:108058
STS
Synonyms
AM
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:110627661-110629820 bp, + strand
From VEGA annotation of GRCm38

  2160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: ADM
Protein SuperFamily: adrenomedullin
Gene Tree: Adm

Human
homologs
ADM, adrenomedullin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 133
neXtProt AC: NX_P35318

Human Synonyms: AM, PAMP

Human Chr (Location): 11p15.4; chr11:10304980-10307402 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation with defects in placental defects, impaired fetal blood vessel and materal spiral artery remodeling, and decreased uterine NK cell numbers.
 
Human Diseases Modeled in Mice Using Adm (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Adm interacts with 124 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process androgen metabolic process, branching involved in labyrinthine layer morphogenesis, ...
Component cytoplasm, cytosol, ...
Function adrenomedullin receptor binding, hormone activity
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (249)    Tissues (183)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 159
RNA in situ 20
In situ reporter (knock in) 9
Northern blot 41
Western blot 2
RT-PCR 18
cDNA source data(136)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase adm    NEW 
Molecular
reagents
All nucleic(146) Genomic(1) cDNA(137) Primer pair(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000046239 (Evidence)
Ensembl Gene Model ENSMUSG00000030790 (Evidence)
Entrez Gene 11535 (Evidence)
UniGene 1408
DFCI TC1575599
DoTS DT.533504
NIA Mouse Gene Index U008631
Consensus CDS Project CCDS21745.1
International Mouse Phenotyping Consortium Status Adm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046239 VEGA Gene Model | MGI Sequence Detail 2160 C57BL/6J ±  kb
transcript OTTMUST00000120570 VEGA | MGI Sequence Detail 1390 Not Applicable 
polypeptide OTTMUSP00000066701 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001710 Adrenomedullin
InterPro IPR021116 Procalcitonin/adrenomedullin
Protein Ontology PR:000003781 ADM protein
References
(Earliest) J:36736 Okazaki T, et al., Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene. Genomics. 1996 Nov 1;37(3):395-9
(Latest) J:214795 Klein KR, et al., Decoy receptor CXCR7 modulates adrenomedullin-mediated cardiac and lymphatic vascular development. Dev Cell. 2014 Sep 8;30(5):528-40
All references(89)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory