Adm
Gene Detail

Symbol Name ID

Adm adrenomedullin MGI:108058

STS

D7Wsu170e

Synonyms

AM

Feature Type

protein coding gene

Genetic Map

Chromosome 7

57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr7:110627669-110629819 bp, + strand From NCBI annotation of GRCm38   2151 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: adrenomedullin
Gene Tree: Adm

Human homologs

Human Homolog		ADM, adrenomedullin
NCBI Gene ID		133
neXtProt AC		NX_P35318
Human Synonyms		AM
Human Chr (Location)		11p15.4; chr11:10326642-10328923 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(12) : Targeted(8) Gene trapped(4)
 

Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation.

 
Human Diseases Modeled Using Mouse Adm (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (38 annotations)

Process	androgen metabolic process, branching involved in labyrinthine layer morphogenesis, ...
Component	cytoplasm, extracellular region, ...
Function	adrenomedullin receptor binding, hormone activity

External Resources: FuncBase

Expression

Literature Summary: (24 records)
Data Summary: Results (26)    Tissues (16)    Images (5)
Theiler Stages: 11, 12, 13, 15, 21, 24, 28

Assay Type	Results
In situ reporter (knock in)	9
RT-PCR	17

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(138) Genomic(1) cDNA(131) Primer pair(5) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000030790 (Evidence)
Entrez Gene	11535 (Evidence)
UniGene	1408
DFCI	TC1575599
DoTS	DT.533504
NIA Mouse Gene Index	U008631
Consensus CDS Project	CCDS21745.1
International Mouse Knockout Project Status	Adm

Sequences

Length	Strain/Species
genomic	11535	NCBI Gene Model | MGI Sequence Detail	2151	C57BL/6J
transcript	NM_009627	RefSeq | MGI Sequence Detail	1381	C57BL/6
polypeptide	P97297	UniProt | EBI | MGI Sequence Detail	184	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001710	Adrenomedullin
InterPro	IPR021116	Procalcitonin/adrenomedullin
Protein Ontology	PR:000003781	ADM

Graphical View of Protein Domain Structure

References

(Earliest) J:38236 White RT, et al., Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem. 1992 May 5;267(13):9210-3
(Latest) J:188706 Yuda K, et al., Adrenomedullin Inhibits Choroidal Neovascularization via CCL2 in the Retinal Pigment Epithelium. Am J Pathol. 2012 Oct;181(4):1464-72
All references(84)

Other accession IDs

MGD-MRK-37094