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Adm
Gene Detail
 Symbol
Name
ID
Adm
adrenomedullin
MGI:108058
STS D7Wsu170e
Synonyms AM
Feature Type protein coding gene
Genetic Map
Chromosome 7
57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr7:110627661-110629820 bp, + strand
From VEGA annotation of GRCm38

  2160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:873  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Protein SuperFamily: adrenomedullin
Gene Tree: Adm

Human
homologs
Human Homolog ADM, adrenomedullin
NCBI Gene ID 133
neXtProt AC  NX_P35318
Human Synonyms  AM
Human Chr (Location)  11p15.4; chr11:10305095-10307376 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(4) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation with defects in placental defects, impaired fetal blood vessel and materal spiral artery remodeling, and decreased uterine NK cell numbers.
 
Human Diseases Modeled Using Mouse Adm (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(5)
Interactions
Adm interacts with 125 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process androgen metabolic process, branching involved in labyrinthine layer morphogenesis, ...
Component cytoplasm, cytosol, ...
Function adrenomedullin receptor binding, hormone activity
External Resources: FuncBase
Expression
Literature Summary: (25 records)
Data Summary: Results (23)    Tissues (16)    Images (5)
Theiler Stages: 11, 12, 13, 15, 21, 24, 28
Assay TypeResults
In situ reporter (knock in) 9
RT-PCR 14
cDNA source data(135)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(142) Genomic(1) cDNA(135) Primer pair(5) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000046239 (Evidence)
Ensembl Gene ModelENSMUSG00000030790 (Evidence)
Entrez Gene11535 (Evidence)
UniGene1408
DFCITC1575599
DoTSDT.533504
NIA Mouse Gene IndexU008631
Consensus CDS ProjectCCDS21745.1
International Mouse Knockout Project StatusAdm
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046239 VEGA Gene Model | MGI Sequence Detail 2160 C57BL/6J ±  kb
transcript OTTMUST00000120570 VEGA | MGI Sequence Detail 1390 Not Applicable 
polypeptide OTTMUSP00000066701 VEGA | MGI Sequence Detail 245 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001710 Adrenomedullin
InterPro IPR021116 Procalcitonin/adrenomedullin
Protein Ontology PR:000003781 ADM
References (Earliest) J:38236 White RT, et al., Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem. 1992 May 5;267(13):9210-3
(Latest) J:206227 Wetzel-Strong SE, et al., Epicardial-derived adrenomedullin drives cardiac hyperplasia during embryogenesis. Dev Dyn. 2014 Feb;243(2):243-56
All references(90)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-37094

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory