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Adm Gene Detail
Summary
  • Symbol
    Adm
  • Name
    adrenomedullin
  • Synonyms
    AM
  • Feature Type
    protein coding gene
  • IDs
    MGI:108058
    NCBI Gene: 11535
Location & Maps
more
  • Sequence Map
    Chr7:110627661-110629820 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2160 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ADM, adrenomedullin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ADM, adrenomedullin
    Orthology source: HomoloGene
  • Synonyms
    AM, PAMP
  • Links
    NCBI Gene ID: 133
    neXtProt AC: NX_P35318

  • Chr Location
    11p15.4; chr11:10304980-10307402 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Adm mouse models

Human Disease Mouse Models
       Hydrops Fetalis, Nonimmune; NIHF   OMIM: 236750 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    55 phenotypes from 7 alleles in 8 genetic backgrounds
    6 phenotypes from multigenic genotypes
    5 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Chemically induced (other)
    1
  • Gene trapped
    4
  • Radiation induced
    1
  • Targeted
    9
  • Genomic Mutations
    2 involving Adm
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit cardiovascular defects, hyrdops fetalis, and lethality at midgestation with defects in placental defects, impaired fetal blood vessel and materal spiral artery remodeling, and decreased uterine NK cell numbers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000046239 VEGA Gene Model | MGI Sequence Detail 2160 C57BL/6J ±  kb
transcript OTTMUST00000120570 VEGA | MGI Sequence Detail 1390 Not Applicable  
polypeptide OTTMUSP00000066701 VEGA | MGI Sequence Detail 245 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 146
    Genomic 1
    cDNA 137
    Primer pair 7
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37094
References
more
  • Summaries
    All 88
    Developmental Gene Expression 27
    Diseases 1
    Gene Ontology 7
    Phenotypes 38
  • Earliest
    J:36736 Okazaki T, et al., Genomic organization, expression, and chromosomal mapping of the mouse adrenomedullin gene. Genomics. 1996 Nov 1;37(3):395-9
  • Latest
    J:225226 Dykes IM, et al., HIC2 is a novel dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Circ Res. 2014 Jun 20;115(1):23-31

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory