About   Help   FAQ
Nfia
Gene Detail
Symbol

Name
ID
Nfia
nuclear factor I/A
MGI:108056
Synonyms
1110047K16Rik, 9430022M17Rik, NF1A, NF1-A
Feature Type
protein coding gene
Genetic Map
Chromosome 4
45.52 cM, cytoband C4-C6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:97772734-98118871 bp, + strand
From VEGA annotation of GRCm38

  346138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFIA
Protein SuperFamily: nuclear factor 1
Gene Tree: Nfia

Human
homologs
NFIA, nuclear factor I/A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4774
neXtProt AC: NX_Q12857

Human Synonyms: CTF, NF1-A, NF-I/A, NFI-A, NFI-L

Human Chr (Location): 1p31.3-p31.2; chr1:61077257-61462788 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Genomic Mutations involving Nfia (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display perinatal lethality, hydrocephalus, agenesis of the corpus callosum and hippocampal commissure. Fertility is surviving homozygotes is compromised. A decrease in the number of heterozygous animals is associated with a maternal effect.
 
Phenotype Images(8)
Interactions
Nfia interacts with 579 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process DNA replication, negative regulation of transcription from RNA polymerase II promoter, ...
Component cell junction, intracellular, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (41 records)
Data Summary: Results (361)    Tissues (271)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 29
RNA in situ 317
Northern blot 8
RT-PCR 7
cDNA source data(35)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA NFIA ; Xenbase nfia    NEW 
Molecular
reagents
All nucleic(41) cDNA(38) Primer pair(2) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene Model OTTMUSG00000007951 (Evidence)
Ensembl Gene Model ENSMUSG00000028565 (Evidence)
Entrez Gene 18027 (Evidence)
DFCI TC1577909, TC1688286, TC1583156, TC1614625, TC1594767, TC1591652
DoTS DT.523102, DT.87049220, DT.94183992, DT.94340797, DT.91335331, DT.91335330, DT.99635059, DT.94340805
Consensus CDS Project CCDS18373.1, CCDS51234.1
International Mouse Phenotyping Consortium Status Nfia
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007951 VEGA Gene Model | MGI Sequence Detail 346138 C57BL/6J ±  kb
transcript OTTMUST00000018038 VEGA | MGI Sequence Detail 9526 Not Applicable 
polypeptide OTTMUSP00000008283 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(16) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(3724 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011173 nuclear factor 1 A-type
References
(Earliest) J:10811 Inoue T, et al., Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J Biol Chem. 1990 Nov 5;265(31):19065-70
(Latest) J:219427 Glasgow SM, et al., Mutual antagonism between Sox10 and NFIA regulates diversification of glial lineages and glioma subtypes. Nat Neurosci. 2014 Oct;17(10):1322-9
All references(80)
Other
accession IDs
MGD-MRK-37092, MGI:1916088, MGI:2444170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory