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Nfia
Gene Detail
 Symbol
Name
ID
Nfia
nuclear factor I/A
MGI:108056
Synonyms 1110047K16Rik, 9430022M17Rik, NF1A, NF1-A
Feature Type protein coding gene
Genetic Map
Chromosome 4
45.52 cM, cytoband C4-C6
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:97772734-98118871 bp, + strand
From VEGA annotation of GRCm38

  346138 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4086  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: nuclear factor 1
Gene Tree: Nfia

Human
homologs
Human Homolog NFIA, nuclear factor I/A
NCBI Gene ID 4774
neXtProt AC  NX_Q12857
Human Synonyms  CTF, NF1-A, NF-I/A, NFI-A, NFI-L
Human Chr (Location)  1p31.3-p31.2; chr1:61077274-61462788 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display perinatal lethality, hydrocephalus, agenesis of the corpus callosum and hippocampal commissure. Fertility is surviving homozygotes is compromised. A decrease in the number of heterozygous animals is associated with a maternal effect.
 
Phenotype Images(8)
Interactions
Nfia interacts with 580 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process DNA replication, positive regulation of transcription, DNA-templated, ...
Component intracellular, nucleus
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (361)    Tissues (263)    Images (76)
Theiler Stages: 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 29
RNA in situ 317
Northern blot 8
RT-PCR 7
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(41) cDNA(38) Primer pair(2) Other(1)
Microarray probesets(10)
Other database
links
VEGA Gene ModelOTTMUSG00000007951 (Evidence)
Ensembl Gene ModelENSMUSG00000028565 (Evidence)
Entrez Gene18027 (Evidence)
DFCITC1577909, TC1583156, TC1591652, TC1594767, TC1614625, TC1688286
DoTSDT.523102, DT.87049220, DT.91335330, DT.91335331, DT.94183992, DT.94340797, DT.94340805, DT.99635059
Consensus CDS ProjectCCDS18373.1, CCDS51234.1
International Mouse Knockout Project StatusNfia
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007951 VEGA Gene Model | MGI Sequence Detail 346138 C57BL/6J ±  kb
transcript OTTMUST00000018038 VEGA | MGI Sequence Detail 9526 Not Applicable 
polypeptide OTTMUSP00000008283 VEGA | MGI Sequence Detail 509 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(16) UniProt(11)
Polymorphisms RFLP(2) : SNPs within 2kb(3724 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000647 CTF transcription factor/nuclear factor 1
InterPro IPR019739 CTF transcription factor/nuclear factor 1, conserved site
InterPro IPR020604 CTF transcription factor/nuclear factor 1, DNA-binding domain
InterPro IPR019548 CTF transcription factor/nuclear factor 1, N-terminal
InterPro IPR003619 MAD homology 1, Dwarfin-type
Protein Ontology PR:000011173 nuclear factor 1 A-type
References (Earliest) J:10811 Inoue T, et al., Isolation of complementary DNAs encoding a cerebellum-enriched nuclear factor I family that activates transcription from the mouse myelin basic protein promoter. J Biol Chem. 1990 Nov 5;265(31):19065-70
(Latest) J:209112 Shimizu H, et al., The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
All references(74)
Other
accession IDs
MGD-MRK-37092, MGI:1916088, MGI:2444170

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory