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Neurod4 Gene Detail
Summary
  • Symbol
    Neurod4
  • Name
    neurogenic differentiation 4
  • Synonyms
    Atoh3, bHLHa4, Math3, MATH-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108055
    NCBI Gene: 11923
Location & Maps
more
  • Sequence Map
    Chr10:130268153-130280240 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12088 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.81 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATH3, ATH-3, Atoh3, bHLHa4, MATH3, MATH-3
  • Links
    NCBI Gene ID: 58158
    neXtProt AC: NX_Q9HD90

  • Chr Location
    12q13.2; chr12:55019945-55030017 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    26 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, ataxia, and high postnatal mortality. Mutants show impaired postnatal cerebellar development, with thinner inner granular cell and molecular layers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048015 Ensembl Gene Model | MGI Sequence Detail 12088 C57BL/6J ±  kb
transcript ENSMUST00000061571 Ensembl | MGI Sequence Detail 3344 Not Applicable  
polypeptide ENSMUSP00000051379 Ensembl | MGI Sequence Detail 330 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    120 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011154 neurogenic differentiation factor 4
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032651 Neurogenic differentiation factor 4
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
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  • All nucleic 48
    Genomic 2
    cDNA 40
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-37091, MGI:2143684
References
more
  • Summaries
    All 93
    Developmental Gene Expression 64
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:36536 Isaka F, et al., Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. Genomics. 1996 Nov 1;37(3):400-2
  • Latest
    J:235721 Menuchin-Lasowski Y, et al., Sip1 regulates the generation of the inner nuclear layer retinal cell lineages in mammals. Development. 2016 Aug 1;143(15):2829-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory