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Neurod4
Gene Detail
Symbol

Name
ID
Neurod4
neurogenic differentiation 4
MGI:108055
Synonyms
Atoh3, bHLHa4, Math3, MATH-3
Feature Type
protein coding gene
Genetic Map
Chromosome 10
77.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr10:130268153-130280240 bp, - strand
From Ensembl annotation of GRCm38

  12088 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEUROD4
Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod4

Human
homologs
NEUROD4, neuronal differentiation 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 58158
neXtProt AC: NX_Q9HD90

Human Synonyms: ATH3, ATH-3, Atoh3, bHLHa4, MATH3, MATH-3

Human Chr (Location): 12q13.2; chr12:55019945-55030017 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit reduced growth, ataxia, and high postnatal mortality. Mutants show impaired postnatal cerebellar development, with thinner inner granular cell and molecular layers.
 
Interactions
Neurod4 interacts with 294 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process amacrine cell differentiation, camera-type eye development, ...
Component nucleus
Function DNA binding, protein dimerization activity
External Resources: FuncBase
Expression
Literature Summary: (63 records)
Data Summary: Results (497)    Tissues (257)    Images (72)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 491
RT-PCR 6
cDNA source data(39)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NEUROD4 ; Xenbase neurod4 ; ZFIN neurod4    NEW 
Molecular
reagents
All nucleic(48) Genomic(2) cDNA(40) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000048015 (Evidence)
Entrez Gene 11923 (Evidence)
UniGene 10695
DFCI TC1581626
DoTS DT.55238815, DT.55230304
NIA Mouse Gene Index U032416
Consensus CDS Project CCDS24353.1
International Mouse Phenotyping Consortium Status Neurod4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000048015 Ensembl Gene Model | MGI Sequence Detail 12088 C57BL/6J ±  kb
transcript ENSMUST00000061571 Ensembl | MGI Sequence Detail 3344 Not Applicable 
polypeptide ENSMUSP00000051379 Ensembl | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011154 neurogenic differentiation factor 4
References
(Earliest) J:36536 Isaka F, et al., Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. Genomics. 1996 Nov 1;37(3):400-2
(Latest) J:216471 Sapkota D, et al., Onecut1 and Onecut2 redundantly regulate early retinal cell fates during development. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4086-95
All references(95)
Other
accession IDs
MGD-MRK-37091, MGI:2143684

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory