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Neurod4 Gene Detail
Summary
  • Symbol
    Neurod4
  • Name
    neurogenic differentiation 4
  • Synonyms
    Atoh3, bHLHa4, Math3, MATH-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108055
    NCBI Gene: 11923
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:130104021-130116109 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 10, 77.81 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    120 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108055
protein coding gene Chr10:130104021-130116123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017948
protein coding gene Chr10:134219553-134233490 (-)
A/J MGP_AJ_G0017918
protein coding gene Chr10:128787131-128799760 (-)
AKR/J MGP_AKRJ_G0017882
protein coding gene Chr10:132562002-132575122 (-)
BALB/cJ MGP_BALBcJ_G0017888
protein coding gene Chr10:129217706-129229520 (-)
C3H/HeJ MGP_C3HHeJ_G0017703
protein coding gene Chr10:132758693-132770520 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018343
protein coding gene Chr10:138761487-138775416 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016002
protein coding gene Chr10:122533470-122544077 (-)
CAST/EiJ MGP_CASTEiJ_G0017266
protein coding gene Chr10:133467966-133482381 (-)
CBA/J MGP_CBAJ_G0017676
protein coding gene Chr10:144428213-144442642 (-)
DBA/2J MGP_DBA2J_G0017786
protein coding gene Chr10:127895887-127909555 (-)
FVB/NJ MGP_FVBNJ_G0017778
protein coding gene Chr10:126781537-126793340 (-)
LP/J MGP_LPJ_G0017858
protein coding gene Chr10:134784481-134799493 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017807
protein coding gene Chr10:147056452-147072507 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018379
protein coding gene Chr10:132633738-132645608 (-)
PWK/PhJ MGP_PWKPhJ_G0017046
protein coding gene Chr10:128031991-128044289 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016840
protein coding gene Chr10:131663028-131674836 (-)
WSB/EiJ MGP_WSBEiJ_G0017319
protein coding gene Chr10:132902855-132915447 (-)



Homology
more
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROD4, neuronal differentiation 4
  • Synonyms
    ATH3, ATH-3, Atoh3, bHLHa4, MATH3, MATH-3
  • Links
    NCBI Gene ID: 58158
    neXtProt AC: NX_Q9HD90
    UniProt: Q9HD90

  • Chr Location
    12q13.2; chr12:55019974-55030017 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    26 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, ataxia, and high postnatal mortality. Mutants show impaired postnatal cerebellar development, with thinner inner granular cell and molecular layers.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048015 Ensembl Gene Model | MGI Sequence Detail 12089 C57BL/6J ±  kb
    transcript ENSMUST00000061571 Ensembl | MGI Sequence Detail 3345 Not Applicable  
    polypeptide ENSMUSP00000051379 Ensembl | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000011154 neurogenic differentiation factor 4
    • InterPro Domains
      IPR036638 Helix-loop-helix DNA-binding domain superfamily
      IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
      IPR022575 Neurogenic differentiation factor, domain of unknown function
      IPR016637 Neurogenic differentiation factor NeuroD
    Molecular
    Reagents
    less
    • All nucleic 54
      Genomic 2
      cDNA 42
      Primer pair 7
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-37091, MGI:2143684
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 75
      Gene Ontology 7
      Phenotypes 11
    • Earliest
      J:36536 Isaka F, et al., Genetic mapping of four mouse bHLH genes related to Drosophila proneural gene atonal. Genomics. 1996 Nov 1;37(3):400-2
    • Latest
      J:328992 Manuel M, et al., Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals. PLoS Biol. 2022 Sep;20(9):e3001563

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory