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Bcl2l2 Gene Detail
Summary
  • Symbol
    Bcl2l2
  • Name
    BCL2-like 2
  • Synonyms
    bclw, Bcl-w, Gtrgal2, Gtrosa41
  • Feature Type
    protein coding gene
  • IDs
    MGI:108052
    NCBI Gene: 12050
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55120900-55125691 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 27.98 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108052
 protein coding gene Chr14:55120834-55125691 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021327
 protein coding gene Chr14:48865369-48870203 (+)
A/J MGP_AJ_G0021286
 protein coding gene Chr14:47900300-47905134 (+)
AKR/J MGP_AKRJ_G0021262
 protein coding gene Chr14:49646706-49651540 (+)
BALB/cJ MGP_BALBcJ_G0021290
 protein coding gene Chr14:47878978-47883831 (+)
C3H/HeJ MGP_C3HHeJ_G0021070
 protein coding gene Chr14:49339012-49343846 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021728
 protein coding gene Chr14:51330273-51336726 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019275
 protein coding gene Chr14:46313643-46318475 (+)
CAST/EiJ MGP_CASTEiJ_G0020589
 protein coding gene Chr14:45576555-45581178 (+)
CBA/J MGP_CBAJ_G0021037
 protein coding gene Chr14:52895655-52900489 (+)
DBA/2J MGP_DBA2J_G0021158
 protein coding gene Chr14:47642391-47647224 (+)
FVB/NJ MGP_FVBNJ_G0021140
 protein coding gene Chr14:47099862-47104697 (+)
LP/J MGP_LPJ_G0021232
 protein coding gene Chr14:49885333-49890167 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021164
 protein coding gene Chr14:52278072-52282907 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021755
 protein coding gene Chr14:48823096-48827930 (+)
PWK/PhJ MGP_PWKPhJ_G0020336
 protein coding gene Chr14:44177410-44182290 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020164
 protein coding gene Chr14:44807119-44811977 (+)
WSB/EiJ MGP_WSBEiJ_G0020642
 protein coding gene Chr14:49116120-49120955 (+)



Homology
more
  • Human Ortholog
    BCL2L2, BCL2 like 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2L2, BCL2 like 2
  • Synonyms
    BCL2-L-2, BCLW, BCL-W, PPP1R51
  • Links
    NCBI Gene ID: 599
    neXtProt AC: NX_Q92843
    UniProt: Q92843

  • Chr Location
    14q11.2; chr14:23298790-23311751 (+)  GRCh38
  • Human Ortholog
    BCL2L2-PABPN1, BCL2L2-PABPN1 readthrough
  • Links
    NCBI Gene ID: 100529063

  • Chr Location
    14q11.2; chr14:23306833-23326175 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human BCL2L2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants are male sterile with progressive loss of germ cells, Sertoli cells and Leydig cells beginning at puberty.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    904
  • Tissues
    87
  • cDNA Data
    12
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12050 NCBI Gene Model | MGI Sequence Detail 4792 C57BL/6J ±  kb
    transcript NM_001417493 RefSeq | MGI Sequence Detail 3661 ZRU/MplStud  
    polypeptide P70345 UniProt | EBI | MGI Sequence Detail 193 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 6
      cDNA 15
      Primer pair 4
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-32102, MGD-MRK-37088, MGI:105063, MGI:1202303, MGI:2145789
    References
    more
    • Summaries
      All 77
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 20
    • Earliest
      J:17687 Swendeman SL, et al., Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2. J Biol Chem. 1994 Apr 15;269(15):11663-71
    • Latest
      J:341382 Wu B, et al., Crk and Crkl Are Required in the Endocardial Lineage for Heart Valve Development. J Am Heart Assoc. 2023 Sep 19;12(18):e029683
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory