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Smyd5 Gene Detail
Summary
  • Symbol
    Smyd5
  • Name
    SET and MYND domain containing 5
  • Synonyms
    MGC:29044, NN8-4AG, Rai15, Rrg1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108048
    NCBI Gene: 232187
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:85408971-85423417 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 37.44 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    229 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108048
 protein coding gene Chr6:85408958-85423417 (+)
129S1/SvImJ ENSMUSG00200040595
 protein coding gene Chr6:82373279-82387752 (+)
A/J ENSMUSG00195035137
 protein coding gene Chr6:82057578-82072011 (+)
AKR/J ENSMUSG00220001815
 protein coding gene Chr6:81020602-81035057 (+)
BALB/cJ ENSMUSG00180015988
 protein coding gene Chr6:82434932-82449384 (+)
C3H/HeJ ENSMUSG00175032190
 protein coding gene Chr6:94957276-94971749 (-)
C57BL/6NJ ENSMUSG00215016889
 protein coding gene Chr6:82430575-82445022 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028577
 protein coding gene Chr6:81574116-81588700 (+)
CAST/EiJ ENSTCUG00005016505
 protein coding gene Chr6:82424082-82438531 (+)
CBA/J ENSMUSG00210035658
 protein coding gene Chr6:82248775-82263250 (+)
DBA/2J ENSMUSG00185039232
 protein coding gene Chr6:82795921-82810390 (+)
FVB/NJ ENSMUSG00205015927
 protein coding gene Chr6:81488554-81502986 (+)
JF1/MsJ ENSUMUG00000016090
 protein coding gene Chr6:81852905-81866159 (+)
LP/J ENSMUSG00230047835
 protein coding gene Chr6:83929956-83944425 (+)
NOD/ShiLtJ ENSMUSG00190028993
 protein coding gene Chr6:81872583-81887013 (+)
NZO/HlLtJ ENSMUSG00225015448
 protein coding gene Chr6:85844184-85858653 (+)
PWK/PhJ ENSLUMG00010005619
 protein coding gene Chr6:81201983-81216434 (+)
SPRET/EiJ ENSMSPG00010029239
 protein coding gene Chr6:83344379-83358761 (+)
WSB/EiJ ENSIUOG00005028503
 protein coding gene Chr6:82811726-82826139 (+)



Homology
more
  • Human Ortholog
    SMYD5, SMYD family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMYD5, SMYD family member 5
  • Synonyms
    NN8-4AG, RAI15, RRG1, ZMYND23
  • Links
    NCBI Gene ID: 10322
    UniProt: Q6GMV2

  • Chr Location
    2p13.2; chr2:73214222-73227229 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    649
  • Tissues
    20
  • cDNA Data
    115
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033706 Ensembl Gene Model | MGI Sequence Detail 14447 C57BL/6J ±  kb
    transcript ENSMUST00000045693 Ensembl | MGI Sequence Detail 2486 Not Applicable  
    polypeptide ENSMUSP00000048537 Ensembl | MGI Sequence Detail 416 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 2
      cDNA 115
      Primer pair 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-37084, MGI:2141690
    References
    more
    • Summaries
      All 66
      Developmental Gene Expression 3
      Gene Ontology 14
      Phenotypes 23
    • Earliest
      J:34386 Shago M, et al., Isolation of a novel retinoic acid-responsive gene by selection of genomic fragments derived from CpG-island-enriched DNA. Mol Cell Biol. 1996 Aug;16(8):4337-48
    • Latest
      J:386463 Rias E, et al., Protocol for isolation of total RNA from mouse whole cochlea using organic solvents. STAR Protoc. 2026 Mar 20;7(1):104376
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory