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Bag1 Gene Detail
Summary
  • Symbol
    Bag1
  • Name
    BCL2-associated athanogene 1
  • Synonyms
    Rap46
  • Feature Type
    protein coding gene
  • IDs
    MGI:108047
    NCBI Gene: 12017
  • Gene Overview
    MyGene.info: BAG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:40936398-40948281 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11884 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.67 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    BAG1, BCL2 associated athanogene 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BAG1, BCL2 associated athanogene 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BAG-1, HAP, RAP46
  • Links
    NCBI Gene ID: 573
    neXtProt AC: NX_Q99933
    UniProt: Q99933

  • Chr Location
    9p13.3; chr9:33252471-33264761 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality and liver hypoplasia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006605 VEGA Gene Model | MGI Sequence Detail 11884 C57BL/6J ±  kb
    transcript OTTMUST00000089455 VEGA | MGI Sequence Detail 1295 Not Applicable  
    polypeptide OTTMUSP00000048886 VEGA | MGI Sequence Detail 355 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      18 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 141
      cDNA 139
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37083
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 8
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:34759 Takayama S, et al., Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 1995 Jan 27;80(2):279-84
    • Latest
      J:215338 Mashukova A, et al., The BAG-1 isoform BAG-1M regulates keratin-associated Hsp70 chaperoning of aPKC in intestinal cells during activation of inflammatory signaling. J Cell Sci. 2014 Aug 15;127(Pt 16):3568-77

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory