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Bag1
Gene Detail
Symbol

Name
ID
Bag1
BCL2-associated athanogene 1
MGI:108047
Synonyms
Rap46
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.67 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:40936398-40948281 bp, - strand
From VEGA annotation of GRCm38

  11884 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3190  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: molecular chaperone regulator BAG-1
Gene Tree: Bag1

Human
homologs
Human Homolog BAG1, BCL2-associated athanogene
NCBI Gene ID 573
neXtProt AC  NX_Q99933
Human Synonyms  BAG-1, HAP, RAP46
Human Chr (Location)  9p12; chr9:33252471-33264761 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(10) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality and liver hypoplasia.
 
Interactions
Bag1 interacts with 35 markers (Mir15a, Mir22, Mir103-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process apoptotic process, chaperone cofactor-dependent protein refolding, ...
Component cytoplasm, cytosol, ...
Function chaperone binding, phosphoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (72)    Tissues (55)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
RT-PCR 46
cDNA source data(138)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(140) cDNA(138) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000006605 (Evidence)
Ensembl Gene ModelENSMUSG00000028416 (Evidence)
Entrez Gene12017 (Evidence)
UniGene688
DFCITC1574471
DoTSDT.494764, DT.91556592
NIA Mouse Gene IndexU024964
PDB2M8S, 2LWP, 1I6Z
Consensus CDS ProjectCCDS38713.1, CCDS51139.1
International Mouse Knockout Project StatusBag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006605 VEGA Gene Model | MGI Sequence Detail 11884 C57BL/6J ±  kb
transcript OTTMUST00000089455 VEGA | MGI Sequence Detail 1295 Not Applicable 
polypeptide OTTMUSP00000048886 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(18 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003103 BAG domain
InterPro IPR017093 Molecular chaperone regulator BAG-1
InterPro IPR000626 Ubiquitin
Protein Ontology PR:000004619 BAG family molecular chaperone regulator 1
References
(Earliest) J:34759 Takayama S, et al., Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 1995 Jan 27;80(2):279-84
(Latest) J:185833 Fernandes R, et al., NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod. 2012;86(5):138, 1-10
All references(51)
Other
accession IDs
MGD-MRK-37083

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory