Bag1
Gene Detail

Symbol Name ID

Bag1 BCL2-associated athanogene 1 MGI:108047

Synonyms

Rap46

Feature Type

protein coding gene

Genetic Map

Chromosome 4

20.67 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:40936398-40948281 bp, - strand From VEGA annotation of GRCm38   11884 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3190  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: molecular chaperone regulator BAG-1
Gene Tree: Bag1

Human homologs

Human Homolog		BAG1, BCL2-associated athanogene
NCBI Gene ID		573
neXtProt AC		NX_Q99933
Human Synonyms		BAG-1, HAP, RAP46
Human Chr (Location)		9p12; chr9:33252469-33264759 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Homozygous null mice display embryonic lethality and liver hypoplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	apoptotic process, chaperone cofactor-dependent protein refolding, ...
Component	cytoplasm, cytosol, ...
Function	chaperone binding, phosphoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (72)    Tissues (55)    Images (25)
Theiler Stages: 17, 19, 20, 21, 22, 23, 28

Assay Type	Results
RNA in situ	26
RT-PCR	46

cDNA source data(137)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(139) cDNA(137) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000006605 (Evidence)
Ensembl Gene Model	ENSMUSG00000028416 (Evidence)
Entrez Gene	12017 (Evidence)
UniGene	688
DFCI	TC1574471
DoTS	DT.494764, DT.91556592
NIA Mouse Gene Index	U024964
PDB	1I6Z
Consensus CDS Project	CCDS38713.1, CCDS51139.1
International Mouse Knockout Project Status	Bag1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006605	VEGA Gene Model | MGI Sequence Detail	11884	C57BL/6J
transcript	OTTMUST00000089455	VEGA | MGI Sequence Detail	1295	Not Applicable
polypeptide	OTTMUSP00000048886	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(41) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003103	BAG domain
InterPro	IPR017093	Molecular chaperone regulator BAG-1
InterPro	IPR000626	Ubiquitin
InterPro	IPR019955	Ubiquitin supergroup
Protein Ontology	PR:000004619	BAG family molecular chaperone regulator 1

References

(Earliest) J:34759 Takayama S, et al., Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity. Cell. 1995 Jan 27;80(2):279-84
(Latest) J:185833 Fernandes R, et al., NLRP5 mediates mitochondrial function in mouse oocytes and embryos. Biol Reprod. 2012;86(5):138, 1-10
All references(50)

Other accession IDs

MGD-MRK-37083