Laptm5 MGI Mouse Gene Detail - MGI:108046 - lysosomal-associated protein transmembrane 5

Laptm5 Gene Detail

Symbol

Laptm5
Name

lysosomal-associated protein transmembrane 5
Synonyms

E3

Feature Type

protein coding gene
IDs

MGI:108046
NCBI Gene: 16792

Sequence Map

Chr4:130913125-130936141 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

23017 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 64.00 cM
Mapping Data

2 experiments

Human Ortholog

LAPTM5, lysosomal protein transmembrane 5

Vertebrate Orthologs

9

Human Ortholog

LAPTM5, lysosomal protein transmembrane 5
Orthology source: HomoloGene, HGNC
Synonyms

CLAST6
Links

HGNC:29612

NCBI Gene ID: 7805

neXtProt AC: NX_Q13571
Chr Location

1p34; chr1:30732468-30757836 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4922
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 frog, western clawed
HCOP

human homology predictions: LAPTM5
Gene Tree

Laptm5

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Phenotype Summary

6 phenotypes from 2 alleles in 2 genetic backgrounds
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

42
Chemically induced (other)

2
Gene trapped

35
Radiation induced

1
Targeted

4
Genomic Mutations

4 involving Laptm5
Incidental Mutations

Mutagenetix , APF

Mice homozygous for a null allele exhibit increased T cell proliferation, increased IL-2 production and a prolognged type IV hypersensitivity response.

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All GO Annotations

8
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

67
Tissues

56
cDNA Data

136
Literature Summary

4

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase laptm5

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Laptm5 interacts with 143 markers (Mir7-2, Mir7b, Mir10b, ...) View All

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All Sequences

103
RefSeq

4
UniProt

18
CCDS

CCDS18712.1
UniGene

271868

			Length	Strain/Species	Flank
genomic	OTTMUSG00000009589	VEGA Gene Model \| MGI Sequence Detail	23017	C57BL/6J	± kb
transcript	OTTMUST00000071143	VEGA \| MGI Sequence Detail	1322	Not Applicable
polypeptide	OTTMUSP00000036398	VEGA \| MGI Sequence Detail	264	Not Applicable

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SNPs within 2kb

220 from dbSNP Build 142

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UniProt

18 Sequences
Protein Ontology

PR:000009666 lysosomal-associated transmembrane protein 5
InterPro Domains

IPR004687 Lysosomal-associated transmembrane protein 4/5

IPR018396 Lysosomal-associated transmembrane protein, 4A/5

IPR018397 Lysosomal-associated transmembrane protein 5

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All nucleic 141

Genomic 2

cDNA 138

Primer pair 1

Microarray probesets 6

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MGD-MRK-37082

Summaries

All 39

Developmental Gene Expression 4

Gene Ontology 4

Phenotypes 16
Earliest

J:34144 Adra CN, et al., LAPTM5: a novel lysosomal-associated multispanning membrane protein preferentially expressed in hematopoietic cells. Genomics. 1996 Jul 15;35(2):328-37
Latest

J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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