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Ccna1
Gene Detail
Symbol

Name
ID
Ccna1
cyclin A1
MGI:108042
Feature Type
protein coding gene
Genetic Map
Chromosome 3
26.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:55045469-55055501 bp, - strand
From VEGA annotation of GRCm38

  10033 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCNA1
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccna1

Human
homologs
CCNA1, cyclin A1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8900
neXtProt AC: NX_P78396

Human Synonyms: CT146

Human Chr (Location): 13q12.3-q13; chr13:36431030-36442882 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile.
 
Interactions
Ccna1 interacts with 29 markers (Mir24-1, Mir24-2, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, cell differentiation, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (35 records)
Data Summary: Results (51)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Western blot 13
RT-PCR 36
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccna1 ; ZFIN ccna1    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000053079 (Evidence)
Ensembl Gene Model ENSMUSG00000027793 (Evidence)
Entrez Gene 12427 (Evidence)
UniGene 4815
DFCI TC1586658
DoTS DT.101712640, DT.60105227, DT.91352015
NIA Mouse Gene Index U024057
Consensus CDS Project CCDS17356.1
International Mouse Phenotyping Consortium Status Ccna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053079 VEGA Gene Model | MGI Sequence Detail 10033 C57BL/6J ±  kb
transcript OTTMUST00000132748 VEGA | MGI Sequence Detail 1560 Not Applicable 
polypeptide OTTMUSP00000070732 VEGA | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(20) UniProt(4)
Polymorphisms
SNPs within 2kb(218 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015453 Cyclin A, chordates
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005114 cyclin-A1
References
(Earliest) J:30821 Sweeney C, et al., A distinct cyclin A is expressed in germ cells in the mouse. Development. 1996 Jan;122(1):53-64
(Latest) J:221298 Wang Y, et al., Deletion of yes-associated protein (YAP) specifically in cardiac and vascular smooth muscle cells reveals a crucial role for YAP in mouse cardiovascular development. Circ Res. 2014 Mar 14;114(6):957-65
All references(75)
Other
accession IDs
MGD-MRK-37078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory