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Ccna1
Gene Detail
Symbol

Name
ID
Ccna1
cyclin A1
MGI:108042
Feature Type
protein coding gene
Genetic Map
Chromosome 3
26.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:55045469-55055055 bp, - strand
From Ensembl annotation of GRCm38

  9587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31203  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CCNA1
Protein SuperFamily: cyclin, A/B/D/E types
Gene Tree: Ccna1

Human
homologs
CCNA1, cyclin A1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8900
neXtProt AC: NX_P78396

Human Synonyms: CT146

Human Chr (Location): 13q12.3-q13; chr13:36431030-36442882 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile.
 
Interactions
Ccna1 interacts with 29 markers (Mir24-1, Mir24-2, Mir93, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell cycle, cell differentiation, ...
Component cytoplasm, cytoskeleton, ...
Function protein binding, protein kinase binding
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (51)    Tissues (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
Western blot 13
RT-PCR 36
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ccna1 ; ZFIN ccna1    NEW 
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(7) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000027793 (Evidence)
Entrez Gene 12427 (Evidence)
UniGene 4815
DFCI TC1586658
DoTS DT.91352015, DT.60105227, DT.101712640
NIA Mouse Gene Index U024057
Consensus CDS Project CCDS17356.1
International Mouse Phenotyping Consortium Status Ccna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027793 Ensembl Gene Model | MGI Sequence Detail 9587 C57BL/6J ±  kb
transcript ENSMUST00000029368 Ensembl | MGI Sequence Detail 1566 Not Applicable 
polypeptide ENSMUSP00000029368 Ensembl | MGI Sequence Detail 421 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(20) UniProt(1)
Polymorphisms
SNPs within 2kb(217 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015453 Cyclin A, G2/mitotic-specific
InterPro IPR004367 Cyclin, C-terminal domain
InterPro IPR013763 Cyclin-like
InterPro IPR006671 Cyclin, N-terminal
Protein Ontology PR:000005114 cyclin-A1
References
(Earliest) J:30821 Sweeney C, et al., A distinct cyclin A is expressed in germ cells in the mouse. Development. 1996 Jan;122(1):53-64
(Latest) J:218949 Perucho L, et al., RPLP1, a crucial ribosomal protein for embryonic development of the nervous system. PLoS One. 2014;9(6):e99956
All references(73)
Other
accession IDs
MGD-MRK-37078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory