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Ccna1 Gene Detail
Summary
  • Symbol
    Ccna1
  • Name
    cyclin A1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108042
    NCBI Gene: 12427
  • Gene Overview
    MyGene.info: CCNA1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:55045469-55055501 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10033 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 26.52 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CCNA1, cyclin A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CCNA1, cyclin A1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT146
  • Links
    NCBI Gene ID: 8900
    neXtProt AC: NX_P78396
    UniProt: P78396

  • Chr Location
    13q13.3; chr13:36430488-36442882 (+)  GRCh38.p7

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null males are infertile due to the arrest of spermatogenesis prior to the first meiotic division. Female mutant mice are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000053079 VEGA Gene Model | MGI Sequence Detail 10033 C57BL/6J ±  kb
    transcript OTTMUST00000132748 VEGA | MGI Sequence Detail 1560 Not Applicable  
    polypeptide OTTMUSP00000070732 VEGA | MGI Sequence Detail 421 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      220 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 12
      Genomic 1
      cDNA 8
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37078
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 40
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:64276 Lyon MF, et al., Dose-response curves for radiation-induced gene mutations in mouse oocytes and their interpretation. Mutat Res. 1979 Nov;63(1):161-73
    • Latest
      J:254235 Lanctot AA, et al., Loss of Brap Results in Premature G1/S Phase Transition and Impeded Neural Progenitor Differentiation. Cell Rep. 2017 Aug 1;20(5):1148-1160

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory