Traf3
Gene Detail

Symbol Name ID

Traf3 TNF receptor-associated factor 3 MGI:108041

Synonyms

CAP-1, CD40bp, CRAF1, LAP1

Feature Type

protein coding gene

Genetic Map

Chromosome 12

60.94 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr12:111166370-111267153 bp, + strand From VEGA annotation of GRCm38   100784 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TNF receptor-associated factor (TRAF)
Gene Tree: Traf3

Human homologs

Human Homolog		TRAF3, Tnf receptor-associated factor 3
NCBI Gene ID		7187
neXtProt AC		NX_Q13114
Human Synonyms		CAP1, CAP-1, CD40bp, CRAF1, IIAE5, LAP1
Human Chr (Location)		14q32.32; chr14:102777479-102911500 (+)  GRCh38
Disease Associations		(1) Diseases Associated with Human TRAF3

Alleles and phenotypes

All alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene results in progressive runting, hypoglycemia, and depletion of peripheral white blood cells, leading to death by 10 days of age. Immune responses to T-dependent antigen are impaired in lethally irradiated mice reconstituted with mutant cells.

 

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	apoptotic process, immune system process, ...
Component	CD40 receptor complex, cytoplasm, ...
Function	coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (76)    Tissues (47)    Images (13)
Theiler Stages: 9, 10, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	37
Northern blot	34
RNase protection	5

cDNA source data(124)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(131) Genomic(5) cDNA(124) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031724 (Evidence)
Ensembl Gene Model	ENSMUSG00000021277 (Evidence)
Entrez Gene	22031 (Evidence)
UniGene	27431
DFCI	TC1587232, TC1606954, TC1634740
DoTS	DT.101140347, DT.530192, DT.91336916, DT.97377059
NIA Mouse Gene Index	U014425
EC	6.3.2.-
PDB	4GHU
Consensus CDS Project	CCDS26175.1, CCDS36563.1
International Mouse Knockout Project Status	Traf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031724	VEGA Gene Model | MGI Sequence Detail	100784	C57BL/6J
transcript	OTTMUST00000078575	VEGA | MGI Sequence Detail	7060	Not Applicable
polypeptide	OTTMUSP00000041797	VEGA | MGI Sequence Detail	567	Not Applicable

All sequences(61) RefSeq(15) UniProt(4)

Polymorphisms

RFLP(2) : SNPs within 2kb(490 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002083	MATH
InterPro	IPR013323	SIAH-type domain
InterPro	IPR027128	TNF receptor-associated factor 3
InterPro	IPR012227	TNF receptor-associated factor TRAF
InterPro	IPR008974	TRAF-like
InterPro	IPR018957	Zinc finger, C3HC4 RING-type
InterPro	IPR013083	Zinc finger, RING/FYVE/PHD-type
InterPro	IPR001841	Zinc finger, RING-type
InterPro	IPR017907	Zinc finger, RING-type, conserved site
InterPro	IPR001293	Zinc finger, TRAF-type
Protein Ontology	PR:000002289	TNF receptor-associated factor 3

References

(Earliest) J:34086 Cheng G, et al., Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8
(Latest) J:208351 Chang JH, et al., TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med. 2014 Jan 13;211(1):137-51
All references(79)

Other accession IDs

MGD-MRK-36169, MGD-MRK-37077, MGI:2144858