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Traf3
Gene Detail
 Symbol
Name
ID
Traf3
TNF receptor-associated factor 3
MGI:108041
Synonyms CAP-1, CD40bp, CRAF1, LAP1
Feature Type protein coding gene
Genetic Map
Chromosome 12
60.94 cM, cytoband F
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr12:111166370-111267153 bp, + strand
From VEGA annotation of GRCm38

  100784 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7981  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: TNF receptor-associated factor (TRAF)
Gene Tree: Traf3

Human
homologs
Human Homolog TRAF3, Tnf receptor-associated factor 3
NCBI Gene ID 7187
neXtProt AC  NX_Q13114
Human Synonyms  CAP1, CAP-1, CD40bp, CRAF1, IIAE5, LAP1
Human Chr (Location)  14q32.32; chr14:102777479-102911500 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TRAF3
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in progressive runting, hypoglycemia, and depletion of peripheral white blood cells, leading to death by 10 days of age. Immune responses to T-dependent antigen are impaired in lethally irradiated mice reconstituted with mutant cells.
 
Interactions
Traf3 interacts with 425 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process apoptotic process, immune system process, ...
Component CD40 receptor complex, cytoplasm, ...
Function coenzyme F420-0 gamma-glutamyl ligase activity, coenzyme F420-2 alpha-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (76)    Tissues (47)    Images (13)
Theiler Stages: 9, 10, 11, 13, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 37
Northern blot 34
RNase protection 5
cDNA source data(124)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(131) Genomic(5) cDNA(124) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031724 (Evidence)
Ensembl Gene ModelENSMUSG00000021277 (Evidence)
Entrez Gene22031 (Evidence)
UniGene27431
DFCITC1587232, TC1606954, TC1634740
DoTSDT.101140347, DT.530192, DT.91336916, DT.97377059
NIA Mouse Gene IndexU014425
EC6.3.2.-
PDB4GHU
Consensus CDS ProjectCCDS26175.1, CCDS36563.1
International Mouse Knockout Project StatusTraf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031724 VEGA Gene Model | MGI Sequence Detail 100784 C57BL/6J ±  kb
transcript OTTMUST00000078575 VEGA | MGI Sequence Detail 7060 Not Applicable 
polypeptide OTTMUSP00000041797 VEGA | MGI Sequence Detail 567 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(15) UniProt(4)
Polymorphisms RFLP(2) : SNPs within 2kb(490 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002083 MATH
InterPro IPR013323 SIAH-type domain
InterPro IPR027128 TNF receptor-associated factor 3
InterPro IPR012227 TNF receptor-associated factor TRAF
InterPro IPR008974 TRAF-like
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
InterPro IPR001293 Zinc finger, TRAF-type
Protein Ontology PR:000002289 TNF receptor-associated factor 3
References (Earliest) J:34086 Cheng G, et al., Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8
(Latest) J:208351 Chang JH, et al., TRAF3 regulates the effector function of regulatory T cells and humoral immune responses. J Exp Med. 2014 Jan 13;211(1):137-51
All references(79)
Other
accession IDs
MGD-MRK-36169, MGD-MRK-37077, MGI:2144858

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory