About   Help   FAQ
Traf3 Gene Detail
Summary
  • Symbol
    Traf3
  • Name
    TNF receptor-associated factor 3
  • Synonyms
    CAP-1, CD40bp, CRAF1, LAP1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108041
    NCBI Gene: 22031
  • Gene Overview
    MyGene.info: TRAF3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr12:111166370-111267153 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      100784 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 60.94 cM, cytoband F
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    TRAF3, TNF receptor associated factor 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRAF3, TNF receptor associated factor 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CAP1, CAP-1, CD40bp, CRAF1, IIAE5, LAP1, RNF118
  • Links
    NCBI Gene ID: 7187
    neXtProt AC: NX_Q13114
    UniProt: Q13114

  • Chr Location
    14q32.32; chr14:102777479-102911500 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in progressive runting, hypoglycemia, and depletion of peripheral white blood cells, leading to death by 10 days of age. Immune responses to T-dependent antigen are impaired in lethally irradiated mice reconstituted with mutant cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    76
  • Tissues
    47
  • cDNA Data
    124
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000031724 VEGA Gene Model | MGI Sequence Detail 100784 C57BL/6J ±  kb
    transcript OTTMUST00000078575 VEGA | MGI Sequence Detail 7060 Not Applicable  
    polypeptide OTTMUSP00000041797 VEGA | MGI Sequence Detail 567 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      484 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      Genomic 5
      cDNA 124
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36169, MGD-MRK-37077, MGI:2144858
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 6
      Gene Ontology 16
      Phenotypes 40
    • Earliest
      J:34086 Cheng G, et al., Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995 Mar 10;267(5203):1494-8
    • Latest
      J:246962 Yao Z, et al., RANKL cytokine enhances TNF-induced osteoclastogenesis independently of TNF receptor associated factor (TRAF) 6 by degrading TRAF3 in osteoclast precursors. J Biol Chem. 2017 Jun 16;292(24):10169-10179
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory