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Cnga2 Gene Detail
Summary
  • Symbol
    Cnga2
  • Name
    cyclic nucleotide gated channel alpha 2
  • Synonyms
    Cnca, Cncg4, OCNC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108040
    NCBI Gene: 12789
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:71991849-72010218 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.15 cM, cytoband A6
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    79 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108040
protein coding gene ChrX:71991849-72010218 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035789
protein coding gene ChrX:67674059-67692206 (+)
A/J MGP_AJ_G0035773
protein coding gene ChrX:67918143-67936133 (+)
AKR/J MGP_AKRJ_G0035695
protein coding gene ChrX:69724662-69746821 (+)
BALB/cJ MGP_BALBcJ_G0035760
protein coding gene ChrX:66950510-66968726 (+)
C3H/HeJ MGP_C3HHeJ_G0035463
protein coding gene ChrX:68184238-68202953 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036290
protein coding gene ChrX:69721612-69741837 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033137
protein coding gene ChrX:67135479-67153514 (+)
CAST/EiJ MGP_CASTEiJ_G0034755
protein coding gene ChrX:53574646-53597018 (+)
CBA/J MGP_CBAJ_G0035438
protein coding gene ChrX:71671241-71689370 (+)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0035542
protein coding gene ChrX:66744636-66762589 (+)
LP/J MGP_LPJ_G0035680
protein coding gene ChrX:68534012-68552099 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035577
protein coding gene ChrX:74232216-74251408 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036311
protein coding gene ChrX:67524200-67542323 (+)
PWK/PhJ MGP_PWKPhJ_G0034455
protein coding gene ChrX:51579638-51598594 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034290
protein coding gene ChrX:54484527-54502714 (+)
WSB/EiJ MGP_WSBEiJ_G0034897
protein coding gene ChrX:66849151-66872441 (+)



Homology
more
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNCA, CNCA1, CNG2, OCNC1, OCNCa, OCNCALPHA
  • Links
    NCBI Gene ID: 1260
    neXtProt AC: NX_Q16280
    UniProt: Q16280

  • Chr Location
    Xq28; chrX:151734746-151745564 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12789 NCBI Gene Model | MGI Sequence Detail 18370 C57BL/6J ±  kb
    transcript NM_007724 RefSeq | MGI Sequence Detail 3099 C57BL/6  
    polypeptide Q62398 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000000698 cyclic nucleotide-gated olfactory channel
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
      IPR005821 Ion transport domain
      IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
      IPR014710 RmlC-like jelly roll fold
    Molecular
    Reagents
    less
    • All nucleic 8
      Genomic 1
      cDNA 7

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-2037, MGD-MRK-37076, MGI:88435
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 33
    • Earliest
      J:35001 Ruiz ML, et al., Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart. J Mol Cell Cardiol. 1996 Jul;28(7):1453-61
    • Latest
      J:256158 Yang T, et al., Social Control of Hypothalamus-Mediated Male Aggression. Neuron. 2017 Aug 16;95(4):955-970.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory