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Cnga2 Gene Detail
Summary
  • Symbol
    Cnga2
  • Name
    cyclic nucleotide gated channel alpha 2
  • Synonyms
    Cnca, Cncg4, OCNC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108040
    NCBI Gene: 12789
Location & Maps
more
  • Sequence Map
    ChrX:71991849-72010218 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      18370 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 37.15 cM, cytoband A6
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel alpha 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CNGA2, cyclic nucleotide gated channel alpha 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CNCA, CNCA1, CNG2, OCNC1, OCNCa, OCNCALPHA
  • Links
    NCBI Gene ID: 1260
    neXtProt AC: NX_Q16280

  • Chr Location
    Xq27; chrX:151734746-151745564 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 5 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Targeted
    9
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit postnatal lethality within 2 days of birth, growth retardation, and abnormal olfactory neuron response to forskolin.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017812 VEGA Gene Model | MGI Sequence Detail 18370 C57BL/6J ±  kb
transcript OTTMUST00000043133 VEGA | MGI Sequence Detail 3064 Not Applicable  
polypeptide OTTMUSP00000019401 VEGA | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    79 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000000698 cyclic nucleotide-gated olfactory channel
  • InterPro Domains
    IPR018488 Cyclic nucleotide-binding, conserved site
    IPR000595 Cyclic nucleotide-binding domain
    IPR018490 Cyclic nucleotide-binding-like
    IPR032406 Cyclic nucleotide-gated channel, C-terminal leucine zipper domain
    IPR005821 Ion transport domain
    IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
    IPR014710 RmlC-like jelly roll fold
Molecular
Reagents
less
  • All nucleic 7
    Genomic 1
    cDNA 6

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-2037, MGD-MRK-37076, MGI:88435
References
more
  • Summaries
    All 62
    Developmental Gene Expression 8
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:35001 Ruiz ML, et al., Cloning and characterization of an olfactory cyclic nucleotide-gated channel expressed in mouse heart. J Mol Cell Cardiol. 1996 Jul;28(7):1453-61
  • Latest
    J:219286 Matsuo T, et al., Genetic dissection of pheromone processing reveals main olfactory system-mediated social behaviors in mice. Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):E311-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory