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Figf
Gene Detail
Symbol

Name
ID
Figf
c-fos induced growth factor
MGI:108037
Synonyms
Vegfd, VEGF-D
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.35 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
ChrX:164373378-164402650 bp, + strand
From VEGA annotation of GRCm38

  29273 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3288  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Figf

Human
homologs
Human Homolog FIGF, c-fos induced growth factor (vascular endothelial growth factor D)
NCBI Gene ID 2277
neXtProt AC  NX_O43915
Human Synonyms  VEGFD, VEGF-D
Human Chr (Location)  Xp22.31; chrX:15345591-15384413 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Gene trapped(7) Targeted(4)
 
Homozygous female and hemizygous male null mice are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.
 
Interactions
Figf interacts with 111 markers (Mir1a-1, Mir1a-2, Mir10a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process angiogenesis, cell differentiation, ...
Component extracellular region, extracellular space, ...
Function chemoattractant activity, growth factor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (79)    Tissues (59)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 69
Northern blot 6
RT-PCR 4
cDNA source data(21)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000019516 (Evidence)
Ensembl Gene ModelENSMUSG00000031380 (Evidence)
Entrez Gene14205 (Evidence)
UniGene297978
DFCITC1662592, TC1586793, TC1679624
DoTSDT.94233520, DT.55153139, DT.488796
Consensus CDS ProjectCCDS30521.1
International Mouse Knockout Project StatusFigf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019516 VEGA Gene Model | MGI Sequence Detail 29273 C57BL/6J ±  kb
transcript OTTMUST00000046607 VEGA | MGI Sequence Detail 2049 Not Applicable 
polypeptide OTTMUSP00000021049 VEGA | MGI Sequence Detail 358 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(6) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023581 Platelet-derived growth factor, conserved site
InterPro IPR000072 Platelet-derived growth factor (PDGF)
Protein Ontology PR:000007520 vascular endothelial growth factor D
References
(Earliest) J:35873 Orlandini M, et al., Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family [corrected; erratum to be published]. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11675-80
(Latest) J:208714 Duong T, et al., VEGFD regulates blood vascular development by modulating SOX18 activity. Blood. 2014 Feb 13;123(7):1102-12
All references(71)
Other
accession IDs
MGD-MRK-37073, MGI:2147877

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory