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Vegfd Gene Detail
Summary
  • Symbol
    Vegfd
  • Name
    vascular endothelial growth factor D
  • Synonyms
    Figf, VEGF-D
  • Feature Type
    protein coding gene
  • IDs
    MGI:108037
    NCBI Gene: 14205
  • Gene Overview
    MyGene.info: VEGFD
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:164373378-164402650 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    57 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108037
protein coding gene ChrX:164373000-164402650 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036255
protein coding gene ChrX:162459362-162494037 (+)
A/J MGP_AJ_G0036225
protein coding gene ChrX:161634890-161664453 (+)
AKR/J MGP_AKRJ_G0036153
protein coding gene ChrX:166823433-166858381 (+)
BALB/cJ MGP_BALBcJ_G0036218
protein coding gene ChrX:159630700-159665923 (+)
C3H/HeJ MGP_C3HHeJ_G0035925
protein coding gene ChrX:162802721-162836106 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036741
protein coding gene ChrX:167211291-167244460 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033561
protein coding gene ChrX:152668844-152698521 (+)
CAST/EiJ MGP_CASTEiJ_G0035213
protein coding gene ChrX:141785120-141816041 (+)
CBA/J MGP_CBAJ_G0035899
protein coding gene ChrX:172079455-172111844 (+)
DBA/2J MGP_DBA2J_G0036065
protein coding gene ChrX:160504389-160537487 (+)
FVB/NJ MGP_FVBNJ_G0035997
protein coding gene ChrX:159644743-159674757 (+)
LP/J MGP_LPJ_G0036150
protein coding gene ChrX:163592457-163625249 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036029
protein coding gene ChrX:180742693-180775551 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036780
protein coding gene ChrX:161944627-161977877 (+)
PWK/PhJ MGP_PWKPhJ_G0034911
protein coding gene ChrX:138560421-138589046 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034732
protein coding gene ChrX:142287819-142325809 (+)
WSB/EiJ MGP_WSBEiJ_G0035348
protein coding gene ChrX:159909379-159942025 (+)



Homology
more
  • Human Ortholog
    VEGFD, vascular endothelial growth factor D
  • Vertebrate Orthologs
    10
  • Human Ortholog
    VEGFD, vascular endothelial growth factor D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FIGF, VEGF-D
  • Links
    NCBI Gene ID: 2277
    neXtProt AC: NX_O43915
    UniProt: O43915

  • Chr Location
    Xp22.2; chrX:15345591-15384413 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3288
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: VEGFD
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous female and hemizygous male null mice are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031380 Ensembl Gene Model | MGI Sequence Detail 29273 C57BL/6J ±  kb
transcript ENSMUST00000033751 Ensembl | MGI Sequence Detail 2049 Not Applicable  
polypeptide ENSMUSP00000033751 Ensembl | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 27
    cDNA 22
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37073, MGI:2147877
References
more
  • Summaries
    All 92
    Developmental Gene Expression 29
    Gene Ontology 14
    Phenotypes 19
  • Earliest
    J:35873 Orlandini M, et al., Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family [corrected; erratum to be published]. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11675-80
  • Latest
    J:259048 Liu X, et al., Wdpcp promotes epicardial EMT and epicardium-derived cell migration to facilitate coronary artery remodeling. Sci Signal. 2018 Feb 27;11(519)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory