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Vegfd Gene Detail
Summary
  • Symbol
    Vegfd
  • Name
    vascular endothelial growth factor D
  • Synonyms
    Figf, VEGF-D
  • Feature Type
    protein coding gene
  • IDs
    MGI:108037
    NCBI Gene: 14205
  • Gene Overview
    MyGene.info: FIGF
Location & Maps
more
  • Sequence Map
    ChrX:164373378-164402650 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29273 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 76.35 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FIGF, c-fos induced growth factor (vascular endothelial growth factor D)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FIGF, c-fos induced growth factor (vascular endothelial growth factor D)
    Orthology source: HomoloGene
  • Synonyms
    VEGFD, VEGF-D
  • Links
    NCBI Gene ID: 2277
    neXtProt AC: NX_O43915

  • Chr Location
    Xp22.31; chrX:15345591-15384413 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3288
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: FIGF
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 2 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    13
  • Gene trapped
    7
  • Targeted
    4
  • Transgenic
    2
Homozygous female and hemizygous male null mice are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019516 VEGA Gene Model | MGI Sequence Detail 29273 C57BL/6J ±  kb
transcript OTTMUST00000046607 VEGA | MGI Sequence Detail 2049 Not Applicable  
polypeptide OTTMUSP00000021049 VEGA | MGI Sequence Detail 358 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    57 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007520 vascular endothelial growth factor D
  • InterPro Domains
    IPR029034 Cystine-knot cytokine
    IPR000072 PDGF/VEGF domain
    IPR023581 Platelet-derived growth factor, conserved site
Molecular
Reagents
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  • All nucleic 26
    cDNA 21
    Primer pair 3
    Other 2

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-37073, MGI:2147877
References
more
  • Summaries
    All 75
    Developmental Gene Expression 26
    Gene Ontology 10
    Phenotypes 17
  • Earliest
    J:35873 Orlandini M, et al., Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family [corrected; erratum to be published]. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11675-80
  • Latest
    J:216439 Lee KM, et al., The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO J. 2014 Nov 3;33(21):2564-80

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory