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Vegfd Gene Detail
Summary
  • Symbol
    Vegfd
  • Name
    vascular endothelial growth factor D
  • Synonyms
    Figf, VEGF-D
  • Feature Type
    protein coding gene
  • IDs
    MGI:108037
    NCBI Gene: 14205
  • Alliance
    genome feature page
  • Transcription Start Sites
    30 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:163156374-163185646 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 76.35 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    665 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108037
 protein coding gene ChrX:163156282-163185646 (+)
129S1/SvImJ ENSMUSG00200024837
 protein coding gene ChrX:139878733-139908031 (+)
A/J ENSMUSG00195015053
 protein coding gene ChrX:144999337-145028640 (+)
AKR/J ENSMUSG00220028433
 protein coding gene ChrX:136878173-136907482 (+)
BALB/cJ ENSMUSG00180038413
 protein coding gene ChrX:140389099-140418395 (+)
C3H/HeJ ENSMUSG00175010248
 protein coding gene ChrX:144934838-144964134 (+)
C57BL/6NJ ENSMUSG00215022529
 protein coding gene ChrX:140774709-140803987 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033561
 protein coding gene ChrX:152668844-152698521 (+)
CAST/EiJ ENSTCUG00005023851
 protein coding gene ChrX:142484885-142514318 (+)
CBA/J ENSMUSG00210028799
 protein coding gene ChrX:142277073-142306365 (+)
DBA/2J ENSMUSG00185030128
 protein coding gene ChrX:157205741-157235038 (+)
FVB/NJ ENSMUSG00205029447
 protein coding gene ChrX:140862925-140892222 (+)
JF1/MsJ ENSUMUG00000029674
 protein coding gene ChrX:177617900-177645794 (+)
LP/J ENSMUSG00230023805
 protein coding gene ChrX:163995660-164024944 (+)
NOD/ShiLtJ ENSMUSG00190030050
 protein coding gene ChrX:141381770-141411049 (+)
NZO/HlLtJ ENSMUSG00225038610
 protein coding gene ChrX:167384034-167413331 (+)
PWK/PhJ ENSLUMG00010040895
 protein coding gene ChrX:138692851-138720603 (+)
SPRET/EiJ ENSMSPG00010024550
 protein coding gene ChrX:143929309-143966140 (+)
WSB/EiJ ENSIUOG00005024638
 protein coding gene ChrX:141818601-141847905 (+)



Homology
more
  • Human Ortholog
    VEGFD, vascular endothelial growth factor D
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VEGFD, vascular endothelial growth factor D
  • Synonyms
    FIGF, VEGF-D
  • Links
    NCBI Gene ID: 2277
    UniProt: O43915

  • Chr Location
    Xp22.2; chrX:15345594-15384509 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female and hemizygous male null mice are morphologically normal, can suckle, and have grossly normal lymphatic system morphology and function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    707
  • Tissues
    82
  • cDNA Data
    25
  • Literature Summary
    33
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031380 Ensembl Gene Model | MGI Sequence Detail 29273 C57BL/6J ±  kb
    transcript ENSMUST00000033751 Ensembl | MGI Sequence Detail 2049 Not Applicable  
    polypeptide ENSMUSP00000033751 Ensembl | MGI Sequence Detail 358 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 25
      Primer pair 5
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37073, MGI:2147877
    References
    more
    • Summaries
      All 118
      Developmental Gene Expression 33
      Gene Ontology 16
      Phenotypes 31
    • Earliest
      J:35873 Orlandini M, et al., Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family [corrected; erratum to be published]. Proc Natl Acad Sci U S A. 1996 Oct 15;93(21):11675-80
    • Latest
      J:377657 Chen K, et al., BACE2-Induced Aberrant Lymphatic Network Aggravates the Local Inflammation in Arteriovenous Fistulas With Hyperphosphatemia. Adv Sci (Weinh). 2025 Nov;12(43):e09632
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory