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Epha6
Gene Detail
Symbol

Name
ID
Epha6
Eph receptor A6
MGI:108034
Synonyms
Ehk2, Hek12, m-ehk2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
34.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:59653483-60605531 bp, - strand
From VEGA annotation of GRCm38

  952049 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56396  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha6

Human
homologs
Human Homolog EPHA6, EPH receptor A6
NCBI Gene ID 285220
neXtProt AC  NX_Q9UF33
Human Synonyms  EHK2, EHK-2, EK12, EPA6, HEK12, PRO57066
Human Chr (Location)  3q11.2; chr3:96814581-97749439 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display discrete learning and memory deficits.
 
Interactions
Epha6 interacts with 134 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process ephrin receptor signaling pathway, phosphorylation, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (26 records)
Data Summary: Results (167)    Tissues (59)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 150
RT-PCR 12
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(11) Primer pair(5) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026143 (Evidence)
Ensembl Gene ModelENSMUSG00000055540 (Evidence)
Entrez Gene13840 (Evidence)
UniGene455790
DFCITC1592119
DoTSDT.101175644, DT.87034196
NIA Mouse Gene IndexU037168
EC2.7.10.1
Consensus CDS ProjectCCDS28260.2
International Mouse Knockout Project StatusEpha6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026143 VEGA Gene Model | MGI Sequence Detail 952049 C57BL/6J ±  kb
transcript OTTMUST00000064565 VEGA | MGI Sequence Detail 3930 Not Applicable 
polypeptide OTTMUSP00000032093 VEGA | MGI Sequence Detail 1130 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(3262 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007126 ephrin type-A receptor 6
References
(Earliest) J:36316 Lee AM, et al., Cloning of m-ehk2 from the murine inner ear, an eph family receptor tyrosine kinase expressed in the developing and adult cochlea. DNA Cell Biol. 1996 Oct;15(10):817-25
(Latest) J:207512 Escalante A, et al., Zic2-dependent axon midline avoidance controls the formation of major ipsilateral tracts in the CNS. Neuron. 2013 Dec 18;80(6):1392-406
All references(58)
Other
accession IDs
MGD-MRK-37070

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory