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Gpr65
Gene Detail
Symbol

Name
ID
Gpr65
G-protein coupled receptor 65
MGI:108031
Synonyms
Dig1, Gpcr25, TDAG8
Feature Type
protein coding gene
Genetic Map
Chromosome 12
49.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:98268635-98276624 bp, + strand
From Ensembl annotation of GRCm38

  7990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: GPR65
Protein SuperFamily: GPR4-like G protein-coupled receptor
Gene Tree: Gpr65

Human
homologs
GPR65, G protein-coupled receptor 65
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8477
neXtProt AC: NX_Q8IYL9

Human Synonyms: hTDAG8, TDAG8

Human Chr (Location): 14q31-q32.1; chr14:88005124-88014811 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(3) Transposon induced(1)
Incidental mutations (data from APF )
 
Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.
 
Interactions
Gpr65 interacts with 125 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (104)    Tissues (97)    Images (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 54
RT-PCR 50
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gpr65    NEW 
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000021886 (Evidence)
Entrez Gene 14744 (Evidence)
UniGene 378924
DFCI TC1587025, TC1711274
DoTS DT.40135569
NIA Mouse Gene Index U014250
Consensus CDS Project CCDS26096.1
International Mouse Phenotyping Consortium Status Gpr65
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021886 Ensembl Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
transcript ENSMUST00000075072 Ensembl | MGI Sequence Detail 2049 Not Applicable 
polypeptide ENSMUSP00000074581 Ensembl | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR005464 Psychosine receptor
Protein Ontology PR:000001665 psychosine receptor
References
(Earliest) J:36260 Choi JW, et al., Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996 Feb 25;168(1):78-84
(Latest) J:210384 Hikiji H, et al., TDAG8 activation inhibits osteoclastic bone resorption. FASEB J. 2014 Feb;28(2):871-9
All references(40)
Other
accession IDs
MGD-MRK-37067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory