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Gpr65
Gene Detail
 Symbol
Name
ID
Gpr65
G-protein coupled receptor 65
MGI:108031
Synonyms Dig1, Gpcr25, TDAG8
Feature Type protein coding gene
Genetic Map
Chromosome 12
49.84 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:98268657-98276632 bp, + strand
From NCBI annotation of GRCm38

  7976 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2675  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: GPR4-like G protein-coupled receptor
Gene Tree: Gpr65

Human
homologs
Human Homolog GPR65, G protein-coupled receptor 65
NCBI Gene ID 8477
neXtProt AC  NX_Q8IYL9
Human Synonyms  hTDAG8, TDAG8
Human Chr (Location)  14q31-q32.1; chr14:88005124-88014811 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(2) Transposon induced(1)
Incidental mutations (data from APF )
 
Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.
 
Interactions
Gpr65 interacts with 126 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process actin cytoskeleton reorganization, activation of Rho GTPase activity, ...
Component integral component of membrane, membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (104)    Tissues (97)    Images (9)
Theiler Stages: 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 54
RT-PCR 50
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(1) cDNA(10) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000021886 (Evidence)
Entrez Gene14744 (Evidence)
UniGene378924
DFCITC1587025, TC1711274
DoTSDT.40135569
NIA Mouse Gene IndexU014250
Consensus CDS ProjectCCDS26096.1
International Mouse Knockout Project StatusGpr65
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14744 NCBI Gene Model | MGI Sequence Detail 7976 C57BL/6J ±  kb
transcript NM_008152 RefSeq | MGI Sequence Detail 2153 C57BL/6 
polypeptide Q61038 UniProt | EBI | MGI Sequence Detail 337 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(62 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR005464 Psychosine receptor
Protein Ontology PR:000001665 psychosine receptor
Graphical View of Protein Domain Structure
References (Earliest) J:36260 Choi JW, et al., Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996 Feb 25;168(1):78-84
(Latest) J:210384 Hikiji H, et al., TDAG8 activation inhibits osteoclastic bone resorption. FASEB J. 2014 Feb;28(2):871-9
All references(40)
Other
accession IDs
MGD-MRK-37067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory