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Gpr65 Gene Detail
Summary
  • Symbol
    Gpr65
  • Name
    G-protein coupled receptor 65
  • Synonyms
    Dig1, Gpcr25, TDAG8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108031
    NCBI Gene: 14744
  • Gene Overview
    MyGene.info: GPR65
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:98268635-98276644 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 49.84 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    62 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108031
protein coding gene Chr12:98268635-98276722 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020004
protein coding gene Chr12:99635224-99643887 (+)
A/J MGP_AJ_G0019959
protein coding gene Chr12:95912813-95920804 (+)
AKR/J MGP_AKRJ_G0019935
protein coding gene Chr12:98502013-98510018 (+)
BALB/cJ MGP_BALBcJ_G0019945
protein coding gene Chr12:96240002-96248201 (+)
C3H/HeJ MGP_C3HHeJ_G0019747
protein coding gene Chr12:99032625-99041136 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020394
protein coding gene Chr12:102659358-102667296 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018008
protein coding gene Chr12:92888436-92896456 (+)
CAST/EiJ MGP_CASTEiJ_G0019293
protein coding gene Chr12:94090242-94098367 (+)
CBA/J MGP_CBAJ_G0019719
protein coding gene Chr12:106481340-106490824 (+)
DBA/2J MGP_DBA2J_G0019830
protein coding gene Chr12:95325302-95333313 (+)
FVB/NJ MGP_FVBNJ_G0019819
protein coding gene Chr12:94047977-94056522 (+)
LP/J MGP_LPJ_G0019906
protein coding gene Chr12:99460845-99469284 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019861
protein coding gene Chr12:110191874-110200915 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020423
protein coding gene Chr12:98059536-98067610 (+)
PWK/PhJ MGP_PWKPhJ_G0019057
protein coding gene Chr12:89928945-89952828 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018853
protein coding gene Chr12:92233323-92241307 (+)
WSB/EiJ MGP_WSBEiJ_G0019347
protein coding gene Chr12:98888569-98897753 (+)



Homology
more
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
    Orthology source: HGNC, HomoloGene
  • Synonyms
    hTDAG8, TDAG8
  • Links
    NCBI Gene ID: 8477
    neXtProt AC: NX_Q8IYL9
    UniProt: Q8IYL9

  • Chr Location
    14q31.3; chr14:88005124-88014811 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021886 Ensembl Gene Model | MGI Sequence Detail 8010 C57BL/6J ±  kb
    transcript ENSMUST00000075072 Ensembl | MGI Sequence Detail 2069 Not Applicable  
    polypeptide ENSMUSP00000074581 Ensembl | MGI Sequence Detail 337 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR017452 GPCR, rhodopsin-like, 7TM
      IPR000276 G protein-coupled receptor, rhodopsin-like
      IPR005464 Psychosine receptor
    Molecular
    Reagents
    less
    • All nucleic 14
      Genomic 1
      cDNA 11
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37067
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 24
    • Earliest
      J:36260 Choi JW, et al., Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996 Feb 25;168(1):78-84
    • Latest
      J:238283 Lin SH, et al., Involvement of TRPV1 and TDAG8 in Pruriception Associated with Noxious Acidosis. J Invest Dermatol. 2017 Jan;137(1):170-178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory