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Gpr65 Gene Detail
Summary
  • Symbol
    Gpr65
  • Name
    G-protein coupled receptor 65
  • Synonyms
    Dig1, Gpcr25, TDAG8
  • Feature Type
    protein coding gene
  • IDs
    MGI:108031
    NCBI Gene: 14744
  • Gene Overview
    MyGene.info: GPR65
Location & Maps
more
  • Sequence Map
    Chr12:98268635-98276624 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      7990 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR65, G protein-coupled receptor 65
    Orthology source: HomoloGene
  • Synonyms
    hTDAG8, TDAG8
  • Links
    NCBI Gene ID: 8477
    neXtProt AC: NX_Q8IYL9

  • Chr Location
    14q31-q32.1; chr14:88005124-88014811 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 3 alleles in 4 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    3
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Gpr65
  • Incidental Mutations
    APF
Homozygous mutant mice have thymocytes and splenocytes that are insensitive to pH-dependent cAMP production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021886 Ensembl Gene Model | MGI Sequence Detail 7990 C57BL/6J ±  kb
transcript ENSMUST00000075072 Ensembl | MGI Sequence Detail 2049 Not Applicable  
polypeptide ENSMUSP00000074581 Ensembl | MGI Sequence Detail 337 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    62 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
    IPR005464 Psychosine receptor
Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 10
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37067
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Gene Ontology 4
    Phenotypes 17
  • Earliest
    J:36260 Choi JW, et al., Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Cell Immunol. 1996 Feb 25;168(1):78-84
  • Latest
    J:228833 Kamide Y, et al., Acidic environment augments FcepsilonRI-mediated production of IL-6 and IL-13 in mast cells. Biochem Biophys Res Commun. 2015 Aug 28;464(3):949-55

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory