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Hyou1 Gene Detail
Summary
  • Symbol
    Hyou1
  • Name
    hypoxia up-regulated 1
  • Synonyms
    140 kDa, Cab140, CBP-140, Grp170, Orp150
  • Feature Type
    protein coding gene
  • IDs
    MGI:108030
    NCBI Gene: 12282
  • Gene Overview
    MyGene.info: HYOU1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44379490-44392369 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    74 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108030
protein coding gene Chr9:44379490-44392369 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034705
protein coding gene Chr9:42863842-42876752 (+)
A/J MGP_AJ_G0034686
protein coding gene Chr9:41667394-41680239 (+)
AKR/J MGP_AKRJ_G0034612
protein coding gene Chr9:42529979-42542866 (+)
BALB/cJ MGP_BALBcJ_G0034677
protein coding gene Chr9:41414800-41428126 (+)
C3H/HeJ MGP_C3HHeJ_G0034388
protein coding gene Chr9:42987813-43000655 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035198
protein coding gene Chr9:44138190-44151792 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032113
protein coding gene Chr9:41245642-41257870 (+)
CAST/EiJ MGP_CASTEiJ_G0033710
protein coding gene Chr9:42833719-42846673 (+)
CBA/J MGP_CBAJ_G0034360
protein coding gene Chr9:45733596-45746460 (+)
DBA/2J MGP_DBA2J_G0034519
protein coding gene Chr9:41570289-41583133 (+)
FVB/NJ MGP_FVBNJ_G0034460
protein coding gene Chr9:40824496-40837775 (+)
LP/J MGP_LPJ_G0034600
protein coding gene Chr9:43166558-43180315 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034504
protein coding gene Chr9:47587201-47600820 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035219
protein coding gene Chr9:42431159-42444043 (+)
PWK/PhJ MGP_PWKPhJ_G0033416
protein coding gene Chr9:41441012-41454086 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033250
protein coding gene Chr9:42751541-42766798 (+)
WSB/EiJ MGP_WSBEiJ_G0033823
protein coding gene Chr9:42470493-42484203 (+)



Homology
more
  • Human Ortholog
    HYOU1, hypoxia up-regulated 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HYOU1, hypoxia up-regulated 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Grp170, GRP-170, HSP12A, ORP150, ORP-150
  • Links
    NCBI Gene ID: 10525
    neXtProt AC: NX_Q9Y4L1
    UniProt: Q9Y4L1

  • Chr Location
    11q23.3; chr11:119044185-119057246 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality. Heterozygous mice display increased susceptibility to induced neuronal cell death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12282 NCBI Gene Model | MGI Sequence Detail 12880 C57BL/6J ±  kb
    transcript NM_021395 RefSeq | MGI Sequence Detail 4432 C57BL/6  
    polypeptide Q9JKR6 UniProt | EBI | MGI Sequence Detail 999 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000008853 hypoxia up-regulated protein 1
    • InterPro Domains
      IPR018181 Heat shock protein 70, conserved site
      IPR013126 Heat shock protein 70 family
      IPR029048 Heat shock protein 70kD, C-terminal domain superfamily
      IPR029047 Heat shock protein 70kD, peptide-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 73
      cDNA 73

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37066, MGI:1330846, MGI:2143035
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 1
      Gene Ontology 10
      Phenotypes 15
    • Earliest
      J:29304 Naved AF, et al., CBP-140, a novel endoplasmic reticulum resident Ca(2+)-binding protein with a carboxy-terminal NDEL sequence showed partial homology with 70-kDa heat shock protein (hsp70). Cell Struct Funct. 1995 Apr;20(2):133-41
    • Latest
      J:207139 Wang H, et al., Enhanced endoplasmic reticulum entry of tumor antigen is crucial for cross-presentation induced by dendritic cell-targeted vaccination. J Immunol. 2013 Dec 15;191(12):6010-21

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory