About   Help   FAQ
Pkn1 Gene Detail
Summary
  • Symbol
    Pkn1
  • Name
    protein kinase N1
  • Synonyms
    F730027O18Rik, PAK1, Pkn, PRK1, Prkcl1, Stk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:108022
    NCBI Gene: 320795
  • Gene Overview
    MyGene.info: PKN1
Location & Maps
more
  • Sequence Map
    Chr8:83669762-83699179 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29418 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 40.22 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    PKN1, protein kinase N1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PKN1, protein kinase N1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DBK, PAK1, PAK-1, PKN, PKN-ALPHA, PRK1, PRKCL1
  • Links
    NCBI Gene ID: 5585
    neXtProt AC: NX_Q16512

  • Chr Location
    19p13.12; chr19:14433053-14471867 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 2 genetic backgrounds
    2 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Pkn1
  • Incidental Mutations
Mice homozygous for a knock-out alle exhibit spontaneously formed GCs and developed an autoimmune-like disease with autoantibody production and glomerulonephritis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025931 VEGA Gene Model | MGI Sequence Detail 29418 C57BL/6J ±  kb
transcript OTTMUST00000064019 VEGA | MGI Sequence Detail 2995 Not Applicable  
polypeptide OTTMUSP00000031748 VEGA | MGI Sequence Detail 951 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    197 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 19

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-37058, MGI:2444757
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 9
    Phenotypes 35
  • Earliest
    J:35777 Batshake B, et al., The mouse genes for the EP1 prostanoid receptor and the PKN protein kinase overlap. Biochem Biophys Res Commun. 1996 Oct 3;227(1):70-6
  • Latest
    J:229595 Quetier I, et al., Knockout of the PKN Family of Rho Effector Kinases Reveals a Non-redundant Role for PKN2 in Developmental Mesoderm Expansion. Cell Rep. 2016 Jan 26;14(3):440-8

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory