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Ear1
Gene Detail
 Symbol
Name
ID
Ear1
eosinophil-associated, ribonuclease A family, member 1
MGI:108021
Feature Type protein coding gene
Genetic Map
Chromosome 14
22.51 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:43818765-43819639 bp, - strand
From VEGA annotation of GRCm38

  875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40596  Vertebrate Homology Class
4 mouse

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ear1

Interactions
Ear1 interacts with 30 markers (Mir129-1, Mir129-2, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process biological_process
Component cytoplasm
Function endonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(2)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034642 (Evidence)
Ensembl Gene ModelENSMUSG00000072601 (Evidence)
Entrez Gene13586 (Evidence)
UniGene86948
EC3.1.27.-
Consensus CDS ProjectCCDS26964.1
International Mouse Knockout Project StatusEar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034642 VEGA Gene Model | MGI Sequence Detail 875 C57BL/6J ±  kb
transcript OTTMUST00000087934 VEGA | MGI Sequence Detail 713 Not Applicable 
polypeptide OTTMUSP00000047897 VEGA | MGI Sequence Detail 155 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(12 from dbSNP Build 137)    SNPs within 2kb including multiple locations(34)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000007280 eosinophil cationic protein 1
References (Earliest) J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
(Latest) J:187002 O'Reilly MA, et al., Neonatal oxygen increases sensitivity to influenza a virus infection in adult mice by suppressing epithelial expression of ear1. Am J Pathol. 2012 Aug;181(2):441-51
All references(19)
Other
accession IDs
MGD-MRK-37057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory