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Ear1
Gene Detail
Symbol

Name
ID
Ear1
eosinophil-associated, ribonuclease A family, member 1
MGI:108021
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.51 cM, cytoband B-C1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:43818765-43819639 bp, - strand
From VEGA annotation of GRCm38

  875 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40596  Vertebrate Homology Class
4 mouse

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ear1

Interactions
Ear1 interacts with 30 markers (Mir129-1, Mir129-2, Mir143, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process RNA phosphodiester bond hydrolysis
Component cytoplasm
Function endonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(2)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(2) cDNA(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034642 (Evidence)
Ensembl Gene Model ENSMUSG00000072601 (Evidence)
Entrez Gene 13586 (Evidence)
UniGene 86948
EC 3.1.27.-
Consensus CDS Project CCDS26964.1
International Mouse Phenotyping Consortium Status Ear1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034642 VEGA Gene Model | MGI Sequence Detail 875 C57BL/6J ±  kb
transcript OTTMUST00000087934 VEGA | MGI Sequence Detail 713 Not Applicable 
polypeptide OTTMUSP00000047897 VEGA | MGI Sequence Detail 155 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(12 from dbSNP Build 137)    SNPs within 2kb including multiple locations(34)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000007280 eosinophil cationic protein 1
References
(Earliest) J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
(Latest) J:187002 O'Reilly MA, et al., Neonatal oxygen increases sensitivity to influenza a virus infection in adult mice by suppressing epithelial expression of ear1. Am J Pathol. 2012 Aug;181(2):441-51
All references(20)
Other
accession IDs
MGD-MRK-37057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory