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Ear2
Gene Detail
Symbol

Name
ID
Ear2
eosinophil-associated, ribonuclease A family, member 2
MGI:108020
Synonyms
eosinophil-derived neurotoxin, liver, Rnase2
Feature Type
protein coding gene
Genetic Map
Chromosome 14
22.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:44102654-44103534 bp, + strand
From VEGA annotation of GRCm38

  881 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40596  Vertebrate Homology Class
4 mouse

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ear2

Mutations,
alleles, and
phenotypes
Incidental mutations (data from Mutagenetix , APF )
Interactions
Ear2 interacts with 33 markers (Mir20a, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process chemotaxis
Component cellular_component
Function endonuclease activity, hydrolase activity, ...
External Resources: FuncBase
Expression
cDNA source data(6)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(6) cDNA(6)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000034641 (Evidence)
Ensembl Gene ModelENSMUSG00000072596 (Evidence)
Entrez Gene13587 (Evidence)
EC3.1.27.-
Consensus CDS ProjectCCDS26968.1
International Mouse Knockout Project StatusEar2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034641 VEGA Gene Model | MGI Sequence Detail 881 C57BL/6J ±  kb
transcript OTTMUST00000087933 VEGA | MGI Sequence Detail 719 Not Applicable 
polypeptide OTTMUSP00000047896 VEGA | MGI Sequence Detail 156 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(33 from dbSNP Build 137)    SNPs within 2kb including multiple locations(55)
Protein-related
information
ResourceIDDescription
InterPro IPR001427 Ribonuclease A
InterPro IPR023411 Ribonuclease A, active site
InterPro IPR023412 Ribonuclease A-domain
Protein Ontology PR:000007281 eosinophil cationic protein 2
References
(Earliest) J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
(Latest) J:87791 Dyer KD, et al., Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene. Mamm Genome. 2004 Mar;15(2):126-34
All references(22)
Other
accession IDs
MGD-MRK-37056

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory