Ear2
Gene Detail

Symbol Name ID

Ear2 eosinophil-associated, ribonuclease A family, member 2 MGI:108020

Synonyms

eosinophil-derived neurotoxin, liver, Rnase2

Feature Type

protein coding gene

Genetic Map

Chromosome 14

22.53 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr14:44102654-44103534 bp, + strand From VEGA annotation of GRCm38   881 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:40596  Vertebrate Homology Class
4 mouse; 1 rhesus macaque

Protein SuperFamily: pyrimidine-specific ribonuclease/angiogenin
Gene Tree: Ear2

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	chemotaxis
Component	cellular_component
Function	endonuclease activity, hydrolase activity, ...

External Resources: FuncBase

Expression

cDNA source data(6)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(6) cDNA(6)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000034641 (Evidence)
Ensembl Gene Model	ENSMUSG00000072596 (Evidence)
Entrez Gene	13587 (Evidence)
EC	3.1.27.-
Consensus CDS Project	CCDS26968.1
International Mouse Knockout Project Status	Ear2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000034641	VEGA Gene Model | MGI Sequence Detail	881	C57BL/6J
transcript	OTTMUST00000087933	VEGA | MGI Sequence Detail	719	Not Applicable
polypeptide	OTTMUSP00000047896	VEGA | MGI Sequence Detail	156	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(20 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001427	Ribonuclease A
InterPro	IPR023411	Ribonuclease A, active site
InterPro	IPR023412	Ribonuclease A, domain
Protein Ontology	PR:000007281	eosinophil cationic protein 2

References

(Earliest) J:36253 Larson KA, et al., Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily. Proc Natl Acad Sci U S A. 1996 Oct 29;93(22):12370-5
(Latest) J:87791 Dyer KD, et al., Identification of a purine-rich intronic enhancer element in the mouse eosinophil-associated ribonuclease 2 (mEar 2) gene. Mamm Genome. 2004 Mar;15(2):126-34
All references(22)

Other accession IDs

MGD-MRK-37056