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Ntsr2
Gene Detail
Symbol

Name
ID
Ntsr2
neurotensin receptor 2
MGI:108018
Synonyms
NT2R, NTRL
Feature Type
protein coding gene
Genetic Map
Chromosome 12
7.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr12:16653470-16660236 bp, + strand
From Ensembl annotation of GRCm38

  6767 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7452  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: neurotensin receptor
Gene Tree: Ntsr2

Human
homologs
Human Homolog NTSR2, neurotensin receptor 2
NCBI Gene ID 23620
neXtProt AC  NX_O95665
Human Synonyms  NTR2
Human Chr (Location)  2p25.1; chr2:11658178-11670203 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice exhibit abnormal thermal nociception. Mice homozygous for different knock-out allele exhibit increased prepulse inhibition and decreased accoustic startle response.
 
Interactions
Ntsr2 interacts with 35 markers (Mir26a-1, Mir29a, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000020591 (Evidence)
Entrez Gene18217 (Evidence)
UniGene281715
DFCITC1677130, TC1581041
DoTSDT.91340571, DT.50316204
NIA Mouse Gene IndexU013787
Consensus CDS ProjectCCDS36407.1
International Mouse Knockout Project StatusNtsr2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020591 Ensembl Gene Model | MGI Sequence Detail 6767 C57BL/6J ±  kb
transcript ENSMUST00000111064 Ensembl | MGI Sequence Detail 1547 Not Applicable 
polypeptide ENSMUSP00000106693 Ensembl | MGI Sequence Detail 416 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
InterPro IPR003984 Neurotensin receptor
InterPro IPR003986 Neurotensin type 2 receptor
Protein Ontology PR:000001628 neurotensin receptor type 2
References
(Earliest) J:35254 Mazella J, et al., Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci. 1996 Sep 15;16(18):5613-20
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(41)
Other
accession IDs
MGD-MRK-37053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory