Ntsr2
Gene Detail

Symbol Name ID

Ntsr2 neurotensin receptor 2 MGI:108018

Synonyms

NT2R, NTRL

Feature Type

protein coding gene

Genetic Map

Chromosome 12

7.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr12:16653470-16660236 bp, + strand From NCBI annotation of GRCm38   6767 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7452  Vertebrate Homology Class
1 human; 1 mouse; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: neurotensin receptor
Gene Tree: Ntsr2

Human homologs

Human Homolog		NTSR2, neurotensin receptor 2
NCBI Gene ID		23620
neXtProt AC		NX_O95665
Human Synonyms		NTR2
Human Chr (Location)		2p25.1; chr2:11798304-11810329 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous null mice exhibit abnormal thermal nociception. Mice homozygous for different knock-out allele exhibit increased prepulse inhibition and decreased accoustic startle response.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	G-protein coupled receptor signaling pathway, neuropeptide signaling pathway, ...
Component	integral to membrane, membrane, ...
Function	G-protein coupled neurotensin receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(9) Genomic(1) cDNA(8)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000020591 (Evidence)
Entrez Gene	18217 (Evidence)
UniGene	281715
DFCI	TC1581041, TC1677130
DoTS	DT.50316204, DT.91340571
NIA Mouse Gene Index	U013787
Consensus CDS Project	CCDS36407.1
International Mouse Knockout Project Status	Ntsr2

Sequences

Length	Strain/Species
genomic	18217	NCBI Gene Model | MGI Sequence Detail	6767	C57BL/6J
transcript	NM_008747	RefSeq | MGI Sequence Detail	1547	C57BL/6
polypeptide	P70310	UniProt | EBI | MGI Sequence Detail	417	Not Applicable

All sequences(21) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR003984	Neurotensin receptor
InterPro	IPR003986	Neurotensin type 2 receptor
Protein Ontology	PR:000001628	neurotensin receptor 2

Graphical View of Protein Domain Structure

References

(Earliest) J:35254 Mazella J, et al., Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci. 1996 Sep 15;16(18):5613-20
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(41)

Other accession IDs

MGD-MRK-37053