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Ntsr2 Gene Detail
Summary
  • Symbol
    Ntsr2
  • Name
    neurotensin receptor 2
  • Synonyms
    NT2R, NTRL
  • Feature Type
    protein coding gene
  • IDs
    MGI:108018
    NCBI Gene: 18217
  • Gene Overview
    MyGene.info: NTSR2
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:16653451-16660236 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 7.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108018
protein coding gene Chr12:16653382-16660236 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019610
protein coding gene Chr12:14044968-14051684 (+)
A/J MGP_AJ_G0019577
protein coding gene Chr12:13554955-13561671 (+)
AKR/J MGP_AKRJ_G0019547
protein coding gene Chr12:14204335-14211062 (+)
BALB/cJ MGP_BALBcJ_G0019553
protein coding gene Chr12:13798460-13805176 (+)
C3H/HeJ MGP_C3HHeJ_G0019358
protein coding gene Chr12:14107430-14114150 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020001
protein coding gene Chr12:14505530-14512382 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017627
protein coding gene Chr12:13052029-13058773 (+)
CAST/EiJ MGP_CASTEiJ_G0018913
protein coding gene Chr12:13986984-13993695 (+)
CBA/J MGP_CBAJ_G0019329
protein coding gene Chr12:15305066-15311766 (+)
DBA/2J MGP_DBA2J_G0019442
protein coding gene Chr12:13470947-13477664 (+)
FVB/NJ MGP_FVBNJ_G0019433
protein coding gene Chr12:13356668-13363370 (+)
LP/J MGP_LPJ_G0019513
protein coding gene Chr12:14163395-14170112 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019468
protein coding gene Chr12:15210442-15217160 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020040
protein coding gene Chr12:13888883-13895599 (+)
PWK/PhJ MGP_PWKPhJ_G0018679
protein coding gene Chr12:13503523-13510327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018469
protein coding gene Chr12:14103009-14109732 (+)
WSB/EiJ MGP_WSBEiJ_G0018964
protein coding gene Chr12:14000557-14007275 (+)



Homology
more
  • Human Ortholog
    NTSR2, neurotensin receptor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    NTSR2, neurotensin receptor 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NTR2
  • Links
    NCBI Gene ID: 23620
    neXtProt AC: NX_O95665
    UniProt: O95665

  • Chr Location
    2p25.1; chr2:11658178-11670206 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit abnormal thermal nociception. Mice homozygous for different knock-out allele exhibit increased prepulse inhibition and decreased accoustic startle response.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18217 NCBI Gene Model | MGI Sequence Detail 6786 C57BL/6J ±  kb
transcript NM_008747 RefSeq | MGI Sequence Detail 1547 C57BL/6  
polypeptide P70310 UniProt | EBI | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 10
    Genomic 2
    cDNA 8

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-37053
References
more
  • Summaries
    All 42
    Developmental Gene Expression 3
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:35254 Mazella J, et al., Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci. 1996 Sep 15;16(18):5613-20
  • Latest
    J:263745 Woodworth HL, et al., Identification of Neurotensin Receptor Expressing Cells in the Ventral Tegmental Area across the Lifespan. eNeuro. 2018 Jan-Feb;5(1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory