Laptm4a MGI Mouse Gene Detail - MGI:108017 - lysosomal-associated protein transmembrane 4A

Symbol

Laptm4a
Name

lysosomal-associated protein transmembrane 4A
Synonyms

mKIAA0108, Mtrp

Feature Type

protein coding gene
IDs

MGI:108017
NCBI Gene: 17775
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:8921664-8938742 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 3.96 cM
Mapping Data

2 experiments

SNPs within 2kb

114 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108017	protein coding gene	Chr12:8921307-8938742 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019589	protein coding gene	Chr12:6006647-6023548 (+)
A/J	MGP_AJ_G0019556	protein coding gene	Chr12:5834414-5851123 (+)
AKR/J	MGP_AKRJ_G0019526	protein coding gene	Chr12:6223586-6240706 (+)
BALB/cJ	MGP_BALBcJ_G0019531	protein coding gene	Chr12:5960398-5977250 (+)
C3H/HeJ	MGP_C3HHeJ_G0019337	protein coding gene	Chr12:6055423-6072985 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019980	protein coding gene	Chr12:6192804-6209720 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017605	protein coding gene	Chr12:5641088-5657509 (+)
CAST/EiJ	MGP_CASTEiJ_G0018892	protein coding gene	Chr12:6047365-6065555 (+)
CBA/J	MGP_CBAJ_G0019308	protein coding gene	Chr12:6733225-6752876 (+)
DBA/2J	MGP_DBA2J_G0019421	protein coding gene	Chr12:5782229-5800078 (+)
FVB/NJ	MGP_FVBNJ_G0019412	protein coding gene	Chr12:5758951-5776053 (+)
LP/J	MGP_LPJ_G0019492	protein coding gene	Chr12:6054239-6071543 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019445	protein coding gene	Chr12:6540272-6557324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020019	protein coding gene	Chr12:5970193-5986942 (+)
PWK/PhJ	MGP_PWKPhJ_G0018658	protein coding gene	Chr12:5852621-5868824 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018449	protein coding gene	Chr12:5973227-5989595 (+)
WSB/EiJ	MGP_WSBEiJ_G0018943	protein coding gene	Chr12:6019412-6041793 (+)

Human Ortholog

LAPTM4A, lysosomal protein transmembrane 4 alpha

Vertebrate Orthologs

10

Human Ortholog

LAPTM4A, lysosomal protein transmembrane 4 alpha
Orthology source: HomoloGene, HGNC
Synonyms

HUMORF13, LAPTM4, MBNT, Mtrp
Links

HGNC:6924

NCBI Gene ID: 9741

neXtProt AC: NX_Q15012

UniProt: Q15012
Chr Location

2p24.1; chr2:20032650-20052028 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7427
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LAPTM4A
Gene Tree

Laptm4a

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Gene trapped

18
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

6 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

9
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

47
Tissues

45
cDNA Data

17
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase laptm4a

ZFIN laptm4a

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Laptm4a interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

49
RefSeq

2
UniProt

5
CCDS

CCDS36402.1

Ensembl

ENSMUSG00000020585 (Evidence)
NCBI Gene

17775

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020585	Ensembl Gene Model \| MGI Sequence Detail	17079	C57BL/6J	± kb
transcript	ENSMUST00000020909	Ensembl \| MGI Sequence Detail	1773	Not Applicable
polypeptide	ENSMUSP00000020909	Ensembl \| MGI Sequence Detail	308	Not Applicable

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UniProt

5 Sequences
InterPro Domains

IPR004687 Lysosomal-associated transmembrane protein 4/5

IPR018396 Lysosomal-associated transmembrane protein, 4A/5

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All nucleic 19

Genomic 1

cDNA 17

Primer pair 1

Microarray probesets 4

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MGD-MRK-37052, MGI:2144718

Summaries

All 38

Developmental Gene Expression 3

Gene Ontology 6

Phenotypes 10
Earliest

J:36266 Hogue DL, et al., Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae. J Biol Chem. 1996 Apr 19;271(16):9801-8
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Laptm4a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112751	Chr12:8921598-8921671 (+)	-29 bp
Tssr112752	Chr12:8921687-8921704 (+)	32 bp
Tssr112753	Chr12:8921707-8921710 (+)	45 bp
Tssr112754	Chr12:8922017-8922028 (+)	359 bp
Tssr112755	Chr12:8922042-8922054 (+)	384 bp
Tssr112756	Chr12:8922061-8922117 (+)	425 bp
Tssr112760	Chr12:8934930-8934942 (+)	13,272 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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