Laptm4a MGI Mouse Gene Detail - MGI:108017 - lysosomal-associated protein transmembrane 4A

Laptm4a Gene Detail

Symbol

Laptm4a
Name

lysosomal-associated protein transmembrane 4A
Synonyms

mKIAA0108, Mtrp

Feature Type

protein coding gene
IDs

MGI:108017
NCBI Gene: 17775

Sequence Map

Chr12:8921664-8938742 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

17079 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 3.96 cM
Mapping Data

2 experiments

Human Ortholog

LAPTM4A, lysosomal protein transmembrane 4 alpha

Vertebrate Orthologs

10

Human Ortholog

LAPTM4A, lysosomal protein transmembrane 4 alpha
Orthology source: HomoloGene, HGNC
Synonyms

HUMORF13, LAPTM4, MBNT, Mtrp
Links

HGNC:6924

NCBI Gene ID: 9741

neXtProt AC: NX_Q15012

UniProt: Q15012
Chr Location

2p24.1; chr2:20032650-20052028 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7427
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: LAPTM4A
Gene Tree

Laptm4a

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

21
Gene trapped

18
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

12 strains or lines available

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All GO Annotations

6
GO References

4

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

47
Tissues

45
cDNA Data

16
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase laptm4a

ZFIN laptm4a

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Laptm4a interacts with 129 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

34
RefSeq

2
UniProt

5
CCDS

CCDS36402.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000042362	VEGA Gene Model \| MGI Sequence Detail	17079	C57BL/6J	± kb
transcript	OTTMUST00000111644	VEGA \| MGI Sequence Detail	1773	Not Applicable
polypeptide	OTTMUSP00000062547	VEGA \| MGI Sequence Detail	308	Not Applicable

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SNPs within 2kb

114 from dbSNP Build 142

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UniProt

5 Sequences
Protein Ontology

PR:000009665 lysosomal-associated transmembrane protein 4A

(term hierarchy)
InterPro Domains

IPR004687 Lysosomal-associated transmembrane protein 4/5

IPR018396 Lysosomal-associated transmembrane protein, 4A/5

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All nucleic 18

Genomic 1

cDNA 16

Primer pair 1

Microarray probesets 4

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MGD-MRK-37052, MGI:2144718

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 10
Earliest

J:36266 Hogue DL, et al., Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae. J Biol Chem. 1996 Apr 19;271(16):9801-8
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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