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Laptm4a Gene Detail
Summary
  • Symbol
    Laptm4a
  • Name
    lysosomal-associated protein transmembrane 4A
  • Synonyms
    mKIAA0108, Mtrp
  • Feature Type
    protein coding gene
  • IDs
    MGI:108017
    NCBI Gene: 17775
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8921664-8938742 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.96 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    114 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108017
protein coding gene Chr12:8921307-8938742 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019589
protein coding gene Chr12:6006647-6023548 (+)
A/J MGP_AJ_G0019556
protein coding gene Chr12:5834414-5851123 (+)
AKR/J MGP_AKRJ_G0019526
protein coding gene Chr12:6223586-6240706 (+)
BALB/cJ MGP_BALBcJ_G0019531
protein coding gene Chr12:5960398-5977250 (+)
C3H/HeJ MGP_C3HHeJ_G0019337
protein coding gene Chr12:6055423-6072985 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019980
protein coding gene Chr12:6192804-6209720 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017605
protein coding gene Chr12:5641088-5657509 (+)
CAST/EiJ MGP_CASTEiJ_G0018892
protein coding gene Chr12:6047365-6065555 (+)
CBA/J MGP_CBAJ_G0019308
protein coding gene Chr12:6733225-6752876 (+)
DBA/2J MGP_DBA2J_G0019421
protein coding gene Chr12:5782229-5800078 (+)
FVB/NJ MGP_FVBNJ_G0019412
protein coding gene Chr12:5758951-5776053 (+)
LP/J MGP_LPJ_G0019492
protein coding gene Chr12:6054239-6071543 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019445
protein coding gene Chr12:6540272-6557324 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020019
protein coding gene Chr12:5970193-5986942 (+)
PWK/PhJ MGP_PWKPhJ_G0018658
protein coding gene Chr12:5852621-5868824 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018449
protein coding gene Chr12:5973227-5989595 (+)
WSB/EiJ MGP_WSBEiJ_G0018943
protein coding gene Chr12:6019412-6041793 (+)



Homology
more
  • Human Ortholog
    LAPTM4A, lysosomal protein transmembrane 4 alpha
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LAPTM4A, lysosomal protein transmembrane 4 alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMORF13, LAPTM4, MBNT, Mtrp
  • Links
    NCBI Gene ID: 9741
    neXtProt AC: NX_Q15012
    UniProt: Q15012

  • Chr Location
    2p24.1; chr2:20032650-20052028 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000020585 Ensembl Gene Model | MGI Sequence Detail 17079 C57BL/6J ±  kb
transcript ENSMUST00000020909 Ensembl | MGI Sequence Detail 1773 Not Applicable  
polypeptide ENSMUSP00000020909 Ensembl | MGI Sequence Detail 308 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR004687 Lysosomal-associated transmembrane protein 4/5
    IPR018396 Lysosomal-associated transmembrane protein, 4A/5
Molecular
Reagents
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  • All nucleic 19
    Genomic 1
    cDNA 17
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-37052, MGI:2144718
References
more
  • Summaries
    All 38
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:36266 Hogue DL, et al., Identification of a novel membrane transporter associated with intracellular membranes by phenotypic complementation in the yeast Saccharomyces cerevisiae. J Biol Chem. 1996 Apr 19;271(16):9801-8
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory