About   Help   FAQ
Polr1b Gene Detail
Summary
  • Symbol
    Polr1b
  • Name
    polymerase (RNA) I polypeptide B
  • Synonyms
    128kDa, D630020H17Rik, RPA116, RPA2, Rpo1-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:108014
    NCBI Gene: 20017
  • Gene Overview
    MyGene.info: POLR1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:129100995-129126594 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      25600 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 62.68 cM, cytoband F3
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    POLR1B, RNA polymerase I subunit B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    POLR1B, RNA polymerase I subunit B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RPA135, RPA2, Rpo1-2
  • Links
    NCBI Gene ID: 84172
    neXtProt AC: NX_Q9H9Y6
    UniProt: Q9H9Y6

  • Chr Location
    2q14.1; chr2:112541915-112577153 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality prior to implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015413 VEGA Gene Model | MGI Sequence Detail 25600 C57BL/6J ±  kb
    transcript OTTMUST00000036590 VEGA | MGI Sequence Detail 3998 Not Applicable  
    polypeptide OTTMUSP00000016426 VEGA | MGI Sequence Detail 1135 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      335 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000012983 DNA-directed RNA polymerase I subunit RPA2
    • EC
    • InterPro Domains
      IPR009674 DNA-directed RNA polymerase I subunit RPA2, domain 4
      IPR015712 DNA-directed RNA polymerase, subunit 2
      IPR007120 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
      IPR037033 DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
      IPR007121 RNA polymerase, beta subunit, conserved site
      IPR007644 RNA polymerase, beta subunit, protrusion
      IPR007642 RNA polymerase Rpb2, domain 2
      IPR037034 RNA polymerase Rpb2, domain 2 superfamily
      IPR007645 RNA polymerase Rpb2, domain 3
      IPR007641 RNA polymerase Rpb2, domain 7
      IPR014724 RNA polymerase Rpb2, OB-fold
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 93
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37048, MGI:2443763
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:237787 Liu X, et al., Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. BMC Immunol. 2016 Aug 02;17(1):25

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory