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Nobox
Gene Detail
Symbol

Name
ID
Nobox
NOBOX oogenesis homeobox
MGI:108011
Synonyms
Og2x
Feature Type
protein coding gene
Genetic Map
Chromosome 6
21.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:43303674-43309554 bp, - strand
From VEGA annotation of GRCm38

  5881 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: NOBOX
Gene Tree: Nobox

Human
homologs
NOBOX, NOBOX oogenesis homeobox
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 135935
neXtProt AC: NX_O60393

Human Synonyms: OG2, OG-2, OG2X, POF5, TCAG_12042

Human Chr (Location): 7q35; chr7:144396914-144410227 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human NOBOX

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display oocyte degeneration after birth, atrophic ovaries, and female infertility.
 
Interactions
Nobox interacts with 44 markers (Mir15a, Mir26a-1, Mir32, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (13 records)
Data Summary: Results (46)    Tissues (36)    Images (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Northern blot 12
RT-PCR 10
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000037623 (Evidence)
Ensembl Gene Model ENSMUSG00000029736 (Evidence)
Entrez Gene 18291 (Evidence)
DFCI TC1681389, TC1587618
DoTS DT.97352689, DT.55277208
NIA Mouse Gene Index U027251
Consensus CDS Project CCDS20093.1
International Mouse Phenotyping Consortium Status Nobox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037623 VEGA Gene Model | MGI Sequence Detail 5881 C57BL/6J ±  kb
transcript OTTMUST00000097059 VEGA | MGI Sequence Detail 1893 Not Applicable 
polypeptide OTTMUSP00000054348 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000011301 homeobox protein NOBOX
References
(Earliest) J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(48)
Other
accession IDs
MGD-MRK-37045, MGI:2135648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory