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Nobox
Gene Detail
 Symbol
Name
ID
Nobox
NOBOX oogenesis homeobox
MGI:108011
Synonyms Og2x
Feature Type protein coding gene
Genetic Map
Chromosome 6
21.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:43303674-43309554 bp, - strand
From VEGA annotation of GRCm38

  5881 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:51066  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

Gene Tree: Nobox

Human
homologs
Human Homolog NOBOX, NOBOX oogenesis homeobox
NCBI Gene ID 135935
neXtProt AC  NX_O60393
Human Synonyms  OG2, OG-2, OG2X, POF5, TCAG_12042
Human Chr (Location)  7q35; chr7:144397240-144410227 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human NOBOX
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Mice homozygous for disruptions in this gene display oocyte degeneration after birth, atrophic ovaries, and female infertility.
 
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cell differentiation, multicellular organismal development, ...
Component cytoplasm, nucleus, ...
Function DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (53)    Tissues (41)    Images (5)
Theiler Stages: 2, 3, 4, 5, 10, 18, 23, 25, 28
Assay TypeResults
RNA in situ 24
Northern blot 12
RT-PCR 17
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(8) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000037623 (Evidence)
Ensembl Gene ModelENSMUSG00000029736 (Evidence)
Entrez Gene18291 (Evidence)
DFCITC1587618, TC1681389
DoTSDT.55277208, DT.97352689
NIA Mouse Gene IndexU027251
Consensus CDS ProjectCCDS20093.1
International Mouse Knockout Project StatusNobox
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037623 VEGA Gene Model | MGI Sequence Detail 5881 C57BL/6J ±  kb
transcript OTTMUST00000097059 VEGA | MGI Sequence Detail 1893 Not Applicable 
polypeptide OTTMUSP00000054348 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(53 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000011301 homeobox protein NOBOX
References (Earliest) J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
(Latest) J:205485 Yu C, et al., CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins. Science. 2013 Dec 20;342(6165):1518-21
All references(46)
Other
accession IDs
MGD-MRK-37045, MGI:2135648

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory