Nobox MGI Mouse Gene Detail - MGI:108011 - NOBOX oogenesis homeobox

Symbol

Nobox
Name

NOBOX oogenesis homeobox
Synonyms

Og2x

Feature Type

protein coding gene
IDs

MGI:108011
NCBI Gene: 18291
Alliance

genome feature page

Sequence Map

Chr6:43280608-43286488 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 21.17 cM
Mapping Data

2 experiments

SNPs within 2kb

284 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108011	protein coding gene	Chr6:43280608-43287006 (-)
129S1/SvImJ	ENSMUSG00200004186	protein coding gene	Chr6:40340902-40346782 (-)
A/J	ENSMUSG00195006546	protein coding gene	Chr6:40243466-40249346 (-)
AKR/J	ENSMUSG00220008906	protein coding gene	Chr6:39909445-39915325 (-)
BALB/cJ	ENSMUSG00180021189	protein coding gene	Chr6:40438119-40443999 (-)
C3H/HeJ	ENSMUSG00175015072	protein coding gene	Chr6:40267080-40272960 (-)
C57BL/6NJ	ENSMUSG00215008564	protein coding gene	Chr6:40393142-40399022 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028321	protein coding gene	Chr6:37991727-37997644 (-)
CAST/EiJ	ENSTCUG00005025742	protein coding gene	Chr6:39790286-39796207 (-)
CBA/J	ENSMUSG00210017563	protein coding gene	Chr6:40316835-40322715 (-)
DBA/2J	ENSMUSG00185013527	protein coding gene	Chr6:40419377-40425257 (-)
FVB/NJ	ENSMUSG00205022601	protein coding gene	Chr6:40308213-40314093 (-)
JF1/MsJ	ENSUMUG00000016826	protein coding gene	Chr6:39946498-39952429 (-)
LP/J	ENSMUSG00230013677	protein coding gene	Chr6:41344133-41350013 (-)
NOD/ShiLtJ	ENSMUSG00190031685	protein coding gene	Chr6:40225220-40231100 (-)
NZO/HlLtJ	ENSMUSG00225015918	protein coding gene	Chr6:43323618-43329498 (-)
PWK/PhJ	ENSLUMG00010042983	protein coding gene	Chr6:39771653-39777581 (-)
SPRET/EiJ	ENSMSPG00010008088	protein coding gene	Chr6:40386809-40392743 (-)
WSB/EiJ	ENSIUOG00005025435	protein coding gene	Chr6:40554598-40560496 (-)

Human Ortholog

NOBOX, NOBOX oogenesis homeobox

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NOBOX, NOBOX oogenesis homeobox
Synonyms

OG-2, OG2, OG2X, POF5, TCAG_12042
Links

HGNC:22448

NCBI Gene ID: 135935

UniProt: O60393
Chr Location

7q35; chr7:144396894-144410227 (-) GRCh38

MGI Vertebrate Homology

Nobox stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NOBOX
Gene Tree

Nobox

Diseases

1 with human NOBOX associations

				Human Disease	Mouse Models
				primary ovarian insufficiency 5 IDs primary ovarian insufficiency 5 DOID:0080862 OMIM:611548

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

16 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

3
Targeted

5
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display oocyte degeneration after birth, atrophic ovaries, and female infertility.

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All GO Annotations

20
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

674
Tissues

46
cDNA Data

9
Literature Summary

32

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN nobox

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All Sequences

39
RefSeq

4
UniProt

2
CCDS

CCDS20093.1

Ensembl

ENSMUSG00000029736 (Evidence)
NCBI Gene

18291

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029736	Ensembl Gene Model \| MGI Sequence Detail	5881	C57BL/6J	± kb
transcript	ENSMUST00000031749	Ensembl \| MGI Sequence Detail	1893	Not Applicable
polypeptide	ENSMUSP00000031749	Ensembl \| MGI Sequence Detail	527	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000011301 homeobox protein NOBOX

(term hierarchy)
InterPro Domains

IPR042988 Homeobox protein NOBOX

IPR001356 Homeodomain

IPR009057 Homeodomain-like superfamily
GlyGen

Q8VIH1 1 site

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All nucleic 16

Genomic 1

cDNA 9

Primer pair 6

Microarray probesets 4

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MGD-MRK-37045, MGI:2135648

Summaries

All 77

Developmental Gene Expression 32

Gene Ontology 10

Phenotypes 17
Earliest

J:35788 Rovescalli AC, et al., Cloning and characterization of four murine homeobox genes. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10691-6
Latest

J:388027 Wang W, et al., CCDC174 deficiency impaired human fertility by affecting the alternative splicing of maternal mRNAs. EMBO Mol Med. 2026 Jun;18(6):2436-2454

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24