Alppl2
Gene Detail

Symbol Name ID

Alppl2 alkaline phosphatase, placental-like 2 MGI:108009

Synonyms

Akp5, D1Ertd816e

Feature Type

protein coding gene

Genetic Map

Chromosome 1

44.05 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:87086690-87089928 bp, - strand From NCBI annotation of GRCm38   3239 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:128715  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 4 cattle; 1 dog; 1 chicken

Protein SuperFamily: alkaline phosphatase
Gene Tree: Alppl2

Human homologs

Human Homolog		ALPP, alkaline phosphatase, placental
NCBI Gene ID		250
neXtProt AC		NX_P05187
Human Synonyms		ALP, PALP, PLAP, PLAP-1
Human Chr (Location)		2q37; chr2:233243348-233247599 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Mice homozygous for a knock-out allele exhibit strain background-dependent differences in the timing of preimplantation cleavage and development, embryo survival, gestational length and litter size.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	dephosphorylation, metabolic process
Component	anchored to membrane, cell surface, ...
Function	alkaline phosphatase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (111)    Tissues (109)    Images (3)
Theiler Stages: 2, 3, 4, 11, 13, 15, 20, 21, 22, 28

Assay Type	Results
RNA in situ	94
RT-PCR	17

cDNA source data(127)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(131) Genomic(2) cDNA(127) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026246 (Evidence)
Entrez Gene	11650 (Evidence)
UniGene	195224
DFCI	TC1575753, TC1628684
DoTS	DT.101175751, DT.532056, DT.94266027, DT.99842199
NIA Mouse Gene Index	U021564
EC	3.1.3.1
Consensus CDS Project	CCDS15126.1
International Mouse Knockout Project Status	Alppl2

Sequences

Length	Strain/Species
genomic	11650	NCBI Gene Model | MGI Sequence Detail	3239	C57BL/6J
transcript	NM_007433	RefSeq | MGI Sequence Detail	2113	C57BL/6
polypeptide	P24823	UniProt | EBI | MGI Sequence Detail	529	Not Applicable

All sequences(25) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001952	Alkaline phosphatase
InterPro	IPR018299	Alkaline phosphatase, active site
InterPro	IPR017849	Alkaline phosphatase-like, alpha/beta/alpha
InterPro	IPR017850	Alkaline-phosphatase-like, core domain
Protein Ontology	PR:000004557	embryonic alkaline phosphatase

Graphical View of Protein Domain Structure

References

(Earliest) J:10994 Manes T, et al., Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes. Genomics. 1990 Nov;8(3):541-54
(Latest) J:187846 Foster BL, et al., Central role of pyrophosphate in acellular cementum formation. PLoS One. 2012;7(6):e38393
All references(35)

Other accession IDs

MGD-MRK-37043, MGI:1289312, MGI:2138659