Upf1
Gene Detail

Symbol Name ID

Upf1 UPF1 regulator of nonsense transcripts homolog (yeast) MGI:107995

Synonyms

B430202H16Rik, PNORF-1, Rent1

Feature Type

protein coding gene

Genetic Map

Chromosome 8

34.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr8:70331522-70353273 bp, - strand From NCBI annotation of GRCm38   21752 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2185  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Upf1

Human homologs

Human Homolog		UPF1, UPF1 regulator of nonsense transcripts homolog (yeast)
NCBI Gene ID		5976
neXtProt AC		NX_Q92900
Human Synonyms		HUPF1, NORF1, pNORF1, RENT1, smg-2
Human Chr (Location)		19p13.2-p13.11; chr19:18942744-18979039 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(1) Gene trapped(8)
 

Mice homozygous for a targeted null mutation are viable in the pre-implantation period but resorb in the early post-implantation period.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	cell cycle, DNA repair, ...
Component	chromatin, cytoplasm, ...
Function	ATP binding, ATP-dependent RNA helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 10, 18, 23, 25, 28

Assay Type	Results
Northern blot	4
RT-PCR	2

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000058301 (Evidence)
Entrez Gene	19704 (Evidence)
DFCI	TC1578956, TC1592867, TC1616289, TC1675364, TC1689472
NIA Mouse Gene Index	U029913
EC	3.6.4.-
Consensus CDS Project	CCDS52572.1
International Mouse Knockout Project Status	Upf1

Sequences

Length	Strain/Species
genomic	19704	NCBI Gene Model | MGI Sequence Detail	21752	C57BL/6J
transcript	NM_001122829	RefSeq | MGI Sequence Detail	4631	C57BL/6
polypeptide	Q9EPU0	UniProt | EBI | MGI Sequence Detail	1124	Not Applicable

All sequences(30) RefSeq(4) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(85 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018999	RNA helicase UPF1, UPF2-interacting domain
Protein Ontology	PR:000017108	regulator of nonsense transcripts 1

Graphical View of Protein Domain Structure

References

(Earliest) J:35791 Perlick HA, et al., Mammalian orthologues of a yeast regulator of nonsense transcript stability. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10928-32
(Latest) J:188025 Cho H, et al., Staufen1-mediated mRNA decay functions in adipogenesis. Mol Cell. 2012 May 25;46(4):495-506
All references(35)

Other accession IDs

MGD-MRK-36575, MGI:2441858