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Slc8a3 Gene Detail
Summary
  • Symbol
    Slc8a3
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 3
  • Synonyms
    Ncx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107976
    NCBI Gene: 110893
Location & Maps
more
  • Sequence Map
    Chr12:81197915-81333180 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      135266 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SLC8A3, solute carrier family 8 member A3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC8A3, solute carrier family 8 member A3
    Orthology source: HomoloGene
  • Synonyms
    NCX3
  • Links
    NCBI Gene ID: 6547
    neXtProt AC: NX_P57103

  • Chr Location
    14q24.1; chr14:70044217-70223612 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Slc8a3
  • Incidental Mutations
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044361 VEGA Gene Model | MGI Sequence Detail 135266 C57BL/6J ±  kb
transcript OTTMUST00000116784 VEGA | MGI Sequence Detail 3433 Not Applicable  
polypeptide OTTMUSP00000065157 VEGA | MGI Sequence Detail 928 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    525 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000015209 sodium/calcium exchanger 3
  • PDB
  • InterPro Domains
    IPR003644 Na-Ca exchanger/integrin-beta4
    IPR032452 Sodium/calcium exchanger domain, C-terminal extension
    IPR004837 Sodium/calcium exchanger membrane region
    IPR004836 Sodium/calcium exchanger protein
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 20
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36556, MGI:2145052
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 10
    Phenotypes 12
  • Earliest
    J:35796 Nicoll DA, et al., Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J Biol Chem. 1996 Oct 4;271(40):24914-21
  • Latest
    J:213182 Michel LY, et al., Function and regulation of the Na+-Ca2+ exchanger NCX3 splice variants in brain and skeletal muscle. J Biol Chem. 2014 Apr 18;289(16):11293-303

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory