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Slc8a3 Gene Detail
Summary
  • Symbol
    Slc8a3
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 3
  • Synonyms
    Ncx3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107976
    NCBI Gene: 110893
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:81197915-81333180 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 37.44 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    525 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107976
protein coding gene Chr12:81197915-81333596 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019898
protein coding gene Chr12:81645275-81784747 (-)
A/J MGP_AJ_G0019856
protein coding gene Chr12:78648964-78786001 (-)
AKR/J MGP_AKRJ_G0019831
protein coding gene Chr12:80805358-80951042 (-)
BALB/cJ MGP_BALBcJ_G0019835
protein coding gene Chr12:78894653-79032020 (-)
C3H/HeJ MGP_C3HHeJ_G0019641
protein coding gene Chr12:81269655-81410438 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020287
protein coding gene Chr12:84028201-84170038 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017906
protein coding gene Chr12:75639692-75773397 (-)
CAST/EiJ MGP_CASTEiJ_G0019191
protein coding gene Chr12:76142607-76284308 (-)
CBA/J MGP_CBAJ_G0019612
protein coding gene Chr12:87290846-87434265 (-)
DBA/2J MGP_DBA2J_G0019727
protein coding gene Chr12:78253054-78387864 (-)
FVB/NJ MGP_FVBNJ_G0019713
protein coding gene Chr12:77078187-77213026 (-)
LP/J MGP_LPJ_G0019799
protein coding gene Chr12:81547316-81690471 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019752
protein coding gene Chr12:90282920-90423125 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020322
protein coding gene Chr12:80333242-80467241 (-)
PWK/PhJ MGP_PWKPhJ_G0018957
protein coding gene Chr12:72659807-72794184 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018751
protein coding gene Chr12:74852609-75002236 (-)
WSB/EiJ MGP_WSBEiJ_G0019244
protein coding gene Chr12:80975118-81119768 (-)



Homology
more
  • Human Ortholog
    SLC8A3, solute carrier family 8 member A3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC8A3, solute carrier family 8 member A3
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NCX3
  • Links
    NCBI Gene ID: 6547
    neXtProt AC: NX_P57103
    UniProt: P57103

  • Chr Location
    14q24.2; chr14:70044217-70189626 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 62645
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC8A3
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display a normal phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000079055 Ensembl Gene Model | MGI Sequence Detail 135266 C57BL/6J ±  kb
    transcript ENSMUST00000182208 Ensembl | MGI Sequence Detail 3433 Not Applicable  
    polypeptide ENSMUSP00000138735 Ensembl | MGI Sequence Detail 928 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 2
      cDNA 20
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36556, MGI:2145052
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 6
      Gene Ontology 10
      Phenotypes 14
    • Earliest
      J:35796 Nicoll DA, et al., Cloning of a third mammalian Na+-Ca2+ exchanger, NCX3. J Biol Chem. 1996 Oct 4;271(40):24914-21
    • Latest
      J:262053 Tan Z, et al., Synergistic co-regulation and competition by a SOX9-GLI-FOXA phasic transcriptional network coordinate chondrocyte differentiation transitions. PLoS Genet. 2018 Apr;14(4):e1007346

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory