Igfals
Gene Detail

Symbol Name ID

Igfals insulin-like growth factor binding protein, acid labile subunit MGI:107973

Synonyms

Albs, ALS

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.53 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:24878770-24882008 bp, + strand From NCBI annotation of GRCm38   3239 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Igfals

Human homologs

Human Homolog		IGFALS, insulin-like growth factor binding protein, acid labile subunit
NCBI Gene ID		3483
neXtProt AC		NX_P35858
Human Synonyms		ALS
Human Chr (Location)		16p13.3; chr16:1840414-1844909 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human IGFALS

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for disruptions in this gene gain weight more slowly after birth and display less growth in long bones.

 
Human Diseases Modeled Using Mouse Igfals (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cell adhesion
Component	extracellular region, insulin-like growth factor ternary complex, ...
Function	insulin-like growth factor binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(3) cDNA(43)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000046070 (Evidence)
Entrez Gene	16005 (Evidence)
UniGene	3135
DFCI	TC1581451
DoTS	DT.530435
NIA Mouse Gene Index	U071830
Consensus CDS Project	CCDS37497.1
International Mouse Knockout Project Status	Igfals

Sequences

Length	Strain/Species
genomic	16005	NCBI Gene Model | MGI Sequence Detail	3239	C57BL/6J
transcript	NM_008340	RefSeq | MGI Sequence Detail	2111	C57BL/6
polypeptide	P70389	UniProt | EBI | MGI Sequence Detail	603	Not Applicable

All sequences(22) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(34 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000008946	insulin-like growth factor-binding protein complex acid labile chain

Graphical View of Protein Domain Structure

References

(Earliest) J:35394 Boisclair YR, et al., Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10028-33
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(41)

Other accession IDs

MGD-MRK-36553