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Igfals
Gene Detail
Symbol

Name
ID
Igfals
insulin-like growth factor binding protein, acid labile subunit
MGI:107973
Synonyms
Albs, ALS
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.53 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:24878770-24882008 bp, + strand
From Ensembl annotation of GRCm38

  3239 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37987  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IGFALS
Gene Tree: Igfals

Human
homologs
IGFALS, insulin-like growth factor binding protein, acid labile subunit
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3483
neXtProt AC: NX_P35858

Human Synonyms: ACLSD, ALS

Human Chr (Location): 16p13.3; chr16:1790413-1794908 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IGFALS

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene gain weight more slowly after birth and display less growth in long bones.
 
Phenotype Images(1)
Interactions
Igfals interacts with 50 markers (Mir18, Mir18b, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell adhesion
Component extracellular exosome, extracellular region, ...
Function insulin-like growth factor binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(45)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase igfals    NEW 
Molecular
reagents
All nucleic(48) Genomic(3) cDNA(45)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000046070 (Evidence)
Entrez Gene 16005 (Evidence)
UniGene 3135
DFCI TC1581451
DoTS DT.530435
NIA Mouse Gene Index U071830
Consensus CDS Project CCDS37497.1
International Mouse Phenotyping Consortium Status Igfals
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046070 Ensembl Gene Model | MGI Sequence Detail 3239 C57BL/6J ±  kb
transcript ENSMUST00000050714 Ensembl | MGI Sequence Detail 2111 Not Applicable 
polypeptide ENSMUSP00000060169 Ensembl | MGI Sequence Detail 603 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000008946 insulin-like growth factor-binding protein complex acid labile chain
References
(Earliest) J:35394 Boisclair YR, et al., Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10028-33
(Latest) J:208805 Kennedy OD, et al., Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar;155(3):987-99
All references(43)
Other
accession IDs
MGD-MRK-36553

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory