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Igfals Gene Detail
Summary
  • Symbol
    Igfals
  • Name
    insulin-like growth factor binding protein, acid labile subunit
  • Synonyms
    Albs, ALS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107973
    NCBI Gene: 16005
  • Gene Overview
    MyGene.info: IGFALS
Location & Maps
more
  • Sequence Map
    Chr17:24878770-24882008 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3239 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
    Orthology source: HomoloGene
  • Synonyms
    ACLSD, ALS
  • Links
    NCBI Gene ID: 3483
    neXtProt AC: NX_P35858

  • Chr Location
    16p13.3; chr16:1790413-1794908 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human IGFALS associations

Human Disease Mouse Models
       Acid-Labile Subunit Deficiency; ACLSD   OMIM: 615961
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene gain weight more slowly after birth and display less growth in long bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046070 Ensembl Gene Model | MGI Sequence Detail 3239 C57BL/6J ±  kb
transcript ENSMUST00000050714 Ensembl | MGI Sequence Detail 2111 Not Applicable  
polypeptide ENSMUSP00000060169 Ensembl | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008946 insulin-like growth factor-binding protein complex acid labile chain
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
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  • All nucleic 48
    Genomic 3
    cDNA 45

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-36553
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:35394 Boisclair YR, et al., Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10028-33
  • Latest
    J:208805 Kennedy OD, et al., Skeletal response of male mice to anabolic hormone therapy in the absence of the Igfals gene. Endocrinology. 2014 Mar;155(3):987-99

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory