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Igfals Gene Detail
Summary
  • Symbol
    Igfals
  • Name
    insulin-like growth factor binding protein, acid labile subunit
  • Synonyms
    Albs, ALS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107973
    NCBI Gene: 16005
  • Gene Overview
    MyGene.info: IGFALS
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24878770-24882008 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.53 cM, cytoband A2-A3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107973
protein coding gene Chr17:24877652-24882011 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023326
protein coding gene Chr17:23904217-23907455 (+)
A/J MGP_AJ_G0023286
protein coding gene Chr17:23240950-23244189 (+)
AKR/J MGP_AKRJ_G0023253
protein coding gene Chr17:23329505-23332743 (+)
BALB/cJ MGP_BALBcJ_G0023291
protein coding gene Chr17:23441471-23444709 (+)
C3H/HeJ MGP_C3HHeJ_G0023051
protein coding gene Chr17:23694103-23697341 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023734
protein coding gene Chr17:24967080-24970318 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021209
protein coding gene Chr17:20701329-20704503 (+)
CAST/EiJ MGP_CASTEiJ_G0022553
protein coding gene Chr17:23549334-23552573 (+)
CBA/J MGP_CBAJ_G0023027
protein coding gene Chr17:25808393-25811631 (+)
DBA/2J MGP_DBA2J_G0023156
protein coding gene Chr17:22833613-22836852 (+)
FVB/NJ MGP_FVBNJ_G0023126
protein coding gene Chr17:22554167-22557405 (+)
LP/J MGP_LPJ_G0023233
protein coding gene Chr17:24209480-24212718 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023145
protein coding gene Chr17:25500815-25504054 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023772
protein coding gene Chr17:23613954-23617193 (+)
PWK/PhJ MGP_PWKPhJ_G0022302
protein coding gene Chr17:21589030-21592268 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022120
protein coding gene Chr17:21678262-21681500 (+)
WSB/EiJ MGP_WSBEiJ_G0022616
protein coding gene Chr17:23686600-23689839 (+)



Homology
more
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    IGFALS, insulin like growth factor binding protein acid labile subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ACLSD, ALS
  • Links
    NCBI Gene ID: 3483
    neXtProt AC: NX_P35858
    UniProt: P35858

  • Chr Location
    16p13.3; chr16:1790413-1794908 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 37987
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: IGFALS
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    1 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene gain weight more slowly after birth and display less growth in long bones.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000046070 Ensembl Gene Model | MGI Sequence Detail 3239 C57BL/6J ±  kb
transcript ENSMUST00000050714 Ensembl | MGI Sequence Detail 2111 Not Applicable  
polypeptide ENSMUSP00000060169 Ensembl | MGI Sequence Detail 603 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000008946 insulin-like growth factor-binding protein complex acid labile chain
  • InterPro Domains
    IPR000483 Cysteine-rich flanking region, C-terminal
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain superfamily
    IPR000372 Leucine-rich repeat N-terminal domain
    IPR003591 Leucine-rich repeat, typical subtype
Molecular
Reagents
less
  • All nucleic 49
    Genomic 3
    cDNA 46

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36553
References
more
  • Summaries
    All 46
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 14
  • Earliest
    J:35394 Boisclair YR, et al., Organization and chromosomal localization of the gene encoding the mouse acid labile subunit of the insulin-like growth factor binding complex. Proc Natl Acad Sci U S A. 1996 Sep 17;93(19):10028-33
  • Latest
    J:245201 Liu Z, et al., Ablation of Hepatic Production of the Acid-Labile Subunit in Bovine-GH Transgenic Mice: Effects on Organ and Skeletal Growth. Endocrinology. 2017 Aug 01;158(8):2556-2571

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory