Slc8a1
Gene Detail

Symbol Name ID

Slc8a1 solute carrier family 8 (sodium/calcium exchanger), member 1 MGI:107956

Synonyms

D930008O12Rik, Ncx1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

51.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:81388691-81649607 bp, - strand From Ensembl annotation of GRCm38   260917 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc8a1

Human homologs

Human Homolog		SLC8A1, solute carrier family 8 (sodium/calcium exchanger), member 1
NCBI Gene ID		6546
neXtProt AC		NX_P32418
Human Synonyms		NCX1
Human Chr (Location)		2p23-p22; chr2:40339286-40739575 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(8) Chemically induced(1)
 

Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (80 annotations)

Process	calcium ion export, calcium ion homeostasis, ...
Component	basolateral plasma membrane, cell projection, ...
Function	ankyrin binding, antiporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (29 records)
Data Summary: Results (502)    Tissues (178)    Images (73)
Theiler Stages: 10, 11, 12, 13, 14, 15, 17, 18, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	420
In situ reporter (knock in)	2
Northern blot	12
Western blot	35
RT-PCR	31

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(23) Primer pair(7)
Microarray probesets(10)

Other database links

Ensembl Gene Model	ENSMUSG00000054640 (Evidence)
Entrez Gene	20541 (Evidence)
DFCI	TC1585847, TC1587320, TC1590201, TC1598010, TC1599084, TC1604241, TC1606852, TC1758441
DoTS	DT.101351304, DT.40142036, DT.482189, DT.91573087, DT.91573881, DT.97376759
NIA Mouse Gene Index	U038091, U282031
Consensus CDS Project	CCDS37706.1, CCDS50191.1
International Mouse Knockout Project Status	Slc8a1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000054640	Ensembl Gene Model | MGI Sequence Detail	260917	C57BL/6J
transcript	ENSMUST00000163680	Ensembl | MGI Sequence Detail	2913	Not Applicable
polypeptide	ENSMUSP00000126373	Ensembl | MGI Sequence Detail	970	Not Applicable

All sequences(68) RefSeq(4) UniProt(12)

Polymorphisms

RFLP(2) : SNPs(1814 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001623	Heat shock protein DnaJ, N-terminal
InterPro	IPR003644	Na-Ca exchanger/integrin-beta4
InterPro	IPR002987	Sodium/calcium exchanger, isoform 1
InterPro	IPR004837	Sodium/calcium exchanger membrane region
InterPro	IPR004836	Sodium/calcium exchanger protein
Protein Ontology	PR:000015207	sodium/calcium exchanger 1

References

(Earliest) J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
(Latest) J:194632 Bai Y, et al., Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. Am J Physiol Heart Circ Physiol. 2013 Feb 1;304(3):H427-35
All references(97)

Other accession IDs

MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999