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Slc8a1
Gene Detail
 Symbol
Name
ID
Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
MGI:107956
Synonyms D930008O12Rik, Ncx1
Feature Type protein coding gene
Genetic Map
Chromosome 17
51.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:81388691-81649607 bp, - strand
From Ensembl annotation of GRCm38

  260917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Slc8a1

Human
homologs
Human Homolog SLC8A1, solute carrier family 8 (sodium/calcium exchanger), member 1
NCBI Gene ID 6546
neXtProt AC  NX_P32418
Human Synonyms  NCX1
Human Chr (Location)  2p22.1; chr2:40112146-40512476 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.
 
Phenotype Images(4)
Interactions
Slc8a1 interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process calcium ion export, calcium ion homeostasis, ...
Component basolateral plasma membrane, cell, ...
Function ankyrin binding, antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (33 records)
Data Summary: Results (590)    Tissues (236)    Images (75)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 463
In situ reporter (knock in) 32
Northern blot 12
Western blot 39
RT-PCR 42
cDNA source data(23)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(24) Primer pair(7)
Microarray probesets(10)
Other database
links
Ensembl Gene ModelENSMUSG00000054640 (Evidence)
Entrez Gene20541 (Evidence)
DFCITC1585847, TC1587320, TC1590201, TC1598010, TC1599084, TC1604241, TC1606852, TC1758441
DoTSDT.101351304, DT.40142036, DT.482189, DT.91573087, DT.91573881, DT.97376759
NIA Mouse Gene IndexU038091, U282031
Consensus CDS ProjectCCDS37706.1, CCDS50191.1
International Mouse Knockout Project StatusSlc8a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054640 Ensembl Gene Model | MGI Sequence Detail 260917 C57BL/6J ±  kb
transcript ENSMUST00000086538 Ensembl | MGI Sequence Detail 2913 Not Applicable 
polypeptide ENSMUSP00000083725 Ensembl | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(102) RefSeq(37) UniProt(12)
Polymorphisms RFLP(2) : SNPs within 2kb(2195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001623 DnaJ domain
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
InterPro IPR002987 Sodium/calcium exchanger, isoform 1
InterPro IPR004837 Sodium/calcium exchanger membrane region
InterPro IPR004836 Sodium/calcium exchanger protein
Protein Ontology PR:000015207 sodium/calcium exchanger 1
References (Earliest) J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
(Latest) J:211449 Tritsch E, et al., An SRF/miR-1 axis regulates NCX1 and annexin A5 protein levels in the normal and failing heart. Cardiovasc Res. 2013 Jun 1;98(3):372-80
All references(103)
Other
accession IDs
MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory