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Slc8a1 Gene Detail
Summary
  • Symbol
    Slc8a1
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 1
  • Synonyms
    D930008O12Rik, Ncx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107956
    NCBI Gene: 20541
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:81388691-81649607 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 51.29 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2191 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107956
protein coding gene Chr17:81373105-81738387 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024069
protein coding gene Chr17:84373443-84677809 (-)
A/J MGP_AJ_G0024027
protein coding gene Chr17:81748660-82009069 (-)
AKR/J MGP_AKRJ_G0023996
protein coding gene Chr17:83063167-83325598 (-)
BALB/cJ MGP_BALBcJ_G0024029
protein coding gene Chr17:81620708-81906534 (-)
C3H/HeJ MGP_C3HHeJ_G0023793
protein coding gene Chr17:83895488-84166001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024473
protein coding gene Chr17:87395243-87679989 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021913
protein coding gene Chr17:77087248-77357903 (-)
CAST/EiJ MGP_CASTEiJ_G0023272
protein coding gene Chr17:84597852-84906571 (-)
CBA/J MGP_CBAJ_G0023767
protein coding gene Chr17:91039470-91359393 (-)
DBA/2J MGP_DBA2J_G0023896
protein coding gene Chr17:80228740-80510642 (-)
FVB/NJ MGP_FVBNJ_G0023862
protein coding gene Chr17:79751313-80033368 (-)
LP/J MGP_LPJ_G0023979
protein coding gene Chr17:85192768-85479209 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023890
protein coding gene Chr17:91078050-91390506 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024518
protein coding gene Chr17:83525488-83817463 (-)
PWK/PhJ MGP_PWKPhJ_G0023018
protein coding gene Chr17:79784323-80101310 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022829
protein coding gene Chr17:80311210-80602983 (-)
WSB/EiJ MGP_WSBEiJ_G0023340
protein coding gene Chr17:84359378-84660740 (-)



Homology
more
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NCX1
  • Links
    NCBI Gene ID: 6546
    neXtProt AC: NX_P32418
    UniProt: P32418

  • Chr Location
    2p22.1; chr2:40112146-40512452 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 69090
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SLC8A1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 7 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    55 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054640 Ensembl Gene Model | MGI Sequence Detail 260917 C57BL/6J ±  kb
    transcript ENSMUST00000163680 Ensembl | MGI Sequence Detail 2913 Not Applicable  
    polypeptide ENSMUSP00000126373 Ensembl | MGI Sequence Detail 970 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • InterPro Domains
      IPR038081 CalX-like domain superfamily
      IPR001623 DnaJ domain
      IPR003644 Na-Ca exchanger/integrin-beta4
      IPR032452 Sodium/calcium exchanger domain, C-terminal extension
      IPR002987 Sodium/calcium exchanger, isoform 1
      IPR004837 Sodium/calcium exchanger membrane region
      IPR004836 Sodium/calcium exchanger protein
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 1
      cDNA 29
      Primer pair 8

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 40
      Gene Ontology 20
      Phenotypes 55
    • Earliest
      J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
    • Latest
      J:256343 Li M, et al., The Role of Na+/Ca2+ Exchanger 1 in Maintaining Ductus Arteriosus Patency. Sci Rep. 2017 Aug 29;7(1):9826

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory