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Slc8a1 Gene Detail
Summary
  • Symbol
    Slc8a1
  • Name
    solute carrier family 8 (sodium/calcium exchanger), member 1
  • Synonyms
    D930008O12Rik, Ncx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107956
    NCBI Gene: 20541
Location & Maps
more
  • Sequence Map
    Chr17:81388691-81649607 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      260917 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 51.29 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLC8A1, solute carrier family 8 member A1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NCX1
  • Links
    NCBI Gene ID: 6546
    neXtProt AC: NX_P32418

  • Chr Location
    2p22.1; chr2:40112146-40512486 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 7 alleles in 8 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (ENU)
    1
  • Targeted
    8
  • Transgenic
    3
  • Incidental Mutations
Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054640 Ensembl Gene Model | MGI Sequence Detail 260917 C57BL/6J ±  kb
transcript ENSMUST00000163680 Ensembl | MGI Sequence Detail 2913 Not Applicable  
polypeptide ENSMUSP00000126373 Ensembl | MGI Sequence Detail 970 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2191 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000015207 sodium/calcium exchanger 1
  • InterPro Domains
    IPR001623 DnaJ domain
    IPR003644 Na-Ca exchanger/integrin-beta4
    IPR032452 Sodium/calcium exchanger domain, C-terminal extension
    IPR002987 Sodium/calcium exchanger, isoform 1
    IPR004837 Sodium/calcium exchanger membrane region
    IPR004836 Sodium/calcium exchanger protein
Molecular
Reagents
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  • All nucleic 32
    Genomic 1
    cDNA 24
    Primer pair 7

    Microarray probesets 10
Other
Accession IDs
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MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999
References
more
  • Summaries
    All 113
    Developmental Gene Expression 36
    Gene Ontology 20
    Phenotypes 51
  • Earliest
    J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory