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Slc8a1
Gene Detail
Symbol

Name
ID
Slc8a1
solute carrier family 8 (sodium/calcium exchanger), member 1
MGI:107956
Synonyms
D930008O12Rik, Ncx1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
51.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:81388691-81649607 bp, - strand
From Ensembl annotation of GRCm38

  260917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69090  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC8A1
Gene Tree: Slc8a1

Human
homologs
SLC8A1, solute carrier family 8 (sodium/calcium exchanger), member 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6546
neXtProt AC: NX_P32418

Human Synonyms: NCX1

Human Chr (Location): 2p22.1; chr2:40112146-40512486 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Targeted(8) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations have underdeveloped, nonbeating hearts with massive apoptosis of myocytes, a dilated pericardium and die around embryonic day 9.5. Heterozygotes exhibit altered responses to experimental cardiac pressure overload.
 
Phenotype Images(4)
Interactions
Slc8a1 interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (95 annotations)
Process calcium ion export, calcium ion homeostasis, ...
Component basolateral plasma membrane, cell, ...
Function ankyrin binding, antiporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (34 records)
Data Summary: Results (590)    Tissues (238)    Images (75)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 463
In situ reporter (knock in) 32
Northern blot 12
Western blot 39
RT-PCR 42
cDNA source data(23)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc8a1 ; ZFIN slc8a1a, slc8a1b    NEW 
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(24) Primer pair(7)
Microarray probesets(10)
Other database
links
Ensembl Gene Model ENSMUSG00000054640 (Evidence)
Entrez Gene 20541 (Evidence)
DFCI TC1606852, TC1585847, TC1604241, TC1587320, TC1599084, TC1598010, TC1590201, TC1758441
DoTS DT.97376759, DT.101351304, DT.40142036, DT.91573881, DT.91573087, DT.482189
NIA Mouse Gene Index U282031, U038091
Consensus CDS Project CCDS37706.1, CCDS50191.1
International Mouse Phenotyping Consortium Status Slc8a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054640 Ensembl Gene Model | MGI Sequence Detail 260917 C57BL/6J ±  kb
transcript ENSMUST00000163680 Ensembl | MGI Sequence Detail 2913 Not Applicable 
polypeptide ENSMUSP00000126373 Ensembl | MGI Sequence Detail 970 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(33) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(2195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001623 DnaJ domain
InterPro IPR003644 Na-Ca exchanger/integrin-beta4
InterPro IPR002987 Sodium/calcium exchanger, isoform 1
InterPro IPR004837 Sodium/calcium exchanger membrane region
InterPro IPR004836 Sodium/calcium exchanger protein
Protein Ontology PR:000015207 sodium/calcium exchanger 1
References
(Earliest) J:47389 Nicoll DA, et al., Molecular cloning and functional expression of the cardiac sarcolemmal Na(+)-Ca2+ exchanger. Science. 1990 Oct 26;250(4980):562-5
(Latest) J:220494 Ousingsawat J, et al., Anoctamin-6 controls bone mineralization by activating the calcium transporter NCX1. J Biol Chem. 2015 Mar 6;290(10):6270-80
All references(111)
Other
accession IDs
MGD-MRK-36536, MGI:2146942, MGI:2147028, MGI:2441999

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory