About   Help   FAQ
Zfp36l1 Gene Detail
Summary
  • Symbol
    Zfp36l1
  • Name
    zinc finger protein 36, C3H type-like 1
  • Synonyms
    Brf1, cMG1, D530020L18Rik, TIS11b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107946
    NCBI Gene: 12192
  • Gene Overview
    MyGene.info: ZFP36L1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80107760-80113013 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 36.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    13 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107946
protein coding gene Chr12:80107754-80113013 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019885
protein coding gene Chr12:80446678-80452178 (-)
A/J MGP_AJ_G0019843
protein coding gene Chr12:77540717-77546047 (-)
AKR/J MGP_AKRJ_G0019818
protein coding gene Chr12:79645542-79652874 (-)
BALB/cJ MGP_BALBcJ_G0019822
protein coding gene Chr12:77792566-77798928 (-)
C3H/HeJ MGP_C3HHeJ_G0019628
protein coding gene Chr12:80123261-80129139 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020274
protein coding gene Chr12:82808495-82813763 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017893
protein coding gene Chr12:74549419-74554644 (-)
CAST/EiJ MGP_CASTEiJ_G0019178
protein coding gene Chr12:74980150-74984187 (-)
CBA/J MGP_CBAJ_G0019599
protein coding gene Chr12:86045905-86055056 (-)
DBA/2J MGP_DBA2J_G0019714
protein coding gene Chr12:77162951-77167094 (-)
FVB/NJ MGP_FVBNJ_G0019700
protein coding gene Chr12:75974063-75979340 (-)
LP/J MGP_LPJ_G0019786
protein coding gene Chr12:80379121-80384997 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019739
protein coding gene Chr12:89076036-89082144 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020309
protein coding gene Chr12:79174483-79180363 (-)
PWK/PhJ MGP_PWKPhJ_G0018944
protein coding gene Chr12:71545378-71550954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018738
protein coding gene Chr12:73662324-73668918 (-)
WSB/EiJ MGP_WSBEiJ_G0019231
protein coding gene Chr12:79797294-79804825 (-)



Homology
more
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein like 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Berg36, BRF1, cMG1, ERF1, ERF-1, RNF162B, TIS11B
  • Links
    NCBI Gene ID: 677
    neXtProt AC: NX_Q07352
    UniProt: Q07352

  • Chr Location
    14q24.1; chr14:68787655-68796243 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12192 NCBI Gene Model | MGI Sequence Detail 5254 C57BL/6J ±  kb
    transcript NM_007564 RefSeq | MGI Sequence Detail 2984 C57BL/6  
    polypeptide P23950 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 146
      cDNA 144
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 12
      Diseases 1
      Gene Ontology 19
      Phenotypes 12
    • Earliest
      J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
    • Latest
      J:261809 Mayer C, et al., Developmental diversification of cortical inhibitory interneurons. Nature. 2018 Mar 22;555(7697):457-462

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory