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Zfp36l1 Gene Detail
Summary
  • Symbol
    Zfp36l1
  • Name
    zinc finger protein 36, C3H type-like 1
  • Synonyms
    Brf1, cMG1, D530020L18Rik, TIS11b
  • Feature Type
    protein coding gene
  • IDs
    MGI:107946
    NCBI Gene: 12192
  • Gene Overview
    MyGene.info: ZFP36L1
Location & Maps
more
  • Sequence Map
    Chr12:80107760-80113013 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5254 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein-like 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ZFP36L1, ZFP36 ring finger protein-like 1
    Orthology source: HomoloGene
  • Synonyms
    Berg36, BRF1, cMG1, ERF1, ERF-1, RNF162B, TIS11B
  • Links
    NCBI Gene ID: 677
    neXtProt AC: NX_Q07352

  • Chr Location
    14q22-q24; chr14:68787655-68796243 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    5
  • Targeted
    6
  • Genomic Mutations
    1 involving Zfp36l1
  • Incidental Mutations
    APF , CvDC
Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12192 NCBI Gene Model | MGI Sequence Detail 5254 C57BL/6J ±  kb
transcript NM_007564 RefSeq | MGI Sequence Detail 2984 C57BL/6  
polypeptide P23950 UniProt | EBI | MGI Sequence Detail 338 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    13 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000017640 zinc finger protein 36, C3H1 type-like 1
  • InterPro Domains
    IPR007635 Tis11B-like protein, N-terminal
    IPR000571 Zinc finger, CCCH-type
Molecular
Reagents
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  • All nucleic 146
    cDNA 144
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053
References
more
  • Summaries
    All 44
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 11
    Phenotypes 10
  • Earliest
    J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
  • Latest
    J:223460 Hyatt LD, et al., Myeloid ZFP36L1 does not regulate inflammation or host defense in mouse models of acute bacterial infection. PLoS One. 2014;9(10):e109072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory