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Zfp36l1
Gene Detail
 Symbol
Name
ID
Zfp36l1
zinc finger protein 36, C3H type-like 1
MGI:107946
Synonyms Brf1, cMG1, D530020L18Rik, TIS11b
Feature Type protein coding gene
Genetic Map
Chromosome 12
36.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr12:80107760-80113013 bp, - strand
From NCBI annotation of GRCm38

  5254 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Zfp36l1

Human
homologs
Human Homolog ZFP36L1, ZFP36 ring finger protein-like 1
NCBI Gene ID 677
neXtProt AC  NX_Q07352
Human Synonyms  Berg36, BRF1, cMG1, ERF1, ERF-1, RNF162B, TIS11B
Human Chr (Location)  14q22-q24; chr14:68787655-68796243 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(5) Targeted(5)
Incidental mutations (data from APF )
 
Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.
 
Human Diseases Modeled Using Mouse Zfp36l1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zfp36l1 interacts with 351 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, cell proliferation, ...
Component cytoplasm, cytosol, ...
Function AU-rich element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (761)    Tissues (136)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 23, 28
Assay TypeResults
RNA in situ 661
RT-PCR 100
cDNA source data(143)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(146) cDNA(144) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000021127 (Evidence)
Entrez Gene12192 (Evidence)
UniGene235132
DFCITC1572640, TC1724971, TC1749740
DoTSDT.101121184, DT.101121185, DT.101121186
NIA Mouse Gene IndexU047737
Consensus CDS ProjectCCDS26010.1
International Mouse Knockout Project StatusZfp36l1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12192 NCBI Gene Model | MGI Sequence Detail 5254 C57BL/6J ±  kb
transcript NM_007564 RefSeq | MGI Sequence Detail 2984 C57BL/6 
polypeptide P23950 UniProt | EBI | MGI Sequence Detail 338 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007635 Tis11B-like protein, N-terminal
InterPro IPR000571 Zinc finger, CCCH-type
Protein Ontology PR:000017640 zinc finger protein 36, C3H1 type-like 1
Graphical View of Protein Domain Structure
References (Earliest) J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(49)
Other
accession IDs
MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory