Zfp36l1
Gene Detail

Symbol Name ID

Zfp36l1 zinc finger protein 36, C3H type-like 1 MGI:107946

Synonyms

Brf1, cMG1, D530020L18Rik, TIS11b

Feature Type

protein coding gene

Genetic Map

Chromosome 12

36.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr12:80107760-80113013 bp, - strand From NCBI annotation of GRCm38   5254 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31276  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 2 zebrafish

Gene Tree: Zfp36l1

Human homologs

Human Homolog		ZFP36L1, ZFP36 ring finger protein-like 1
NCBI Gene ID		677
neXtProt AC		NX_Q07352
Human Synonyms		Berg36, BRF1, cMG1, ERF1, ERF-1, RNF162B, TIS11B
Human Chr (Location)		14q22-q24; chr14:69254372-69262960 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(5)
 

Homozygous null mice display embryonic lethality with failure of chorioallantoic fusion.

 
Human Diseases Modeled Using Mouse Zfp36l1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	mRNA catabolic process, nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, ...
Component	cytoplasm, cytosol, ...
Function	AU-rich element binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (768)    Tissues (141)    Images (26)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 23, 28

Assay Type	Results
RNA in situ	661
RT-PCR	107

cDNA source data(95)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(98) cDNA(96) Primer pair(2)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000021127 (Evidence)
Entrez Gene	12192 (Evidence)
UniGene	235132
DFCI	TC1572640, TC1724971, TC1749740
DoTS	DT.101121184, DT.101121185, DT.101121186
NIA Mouse Gene Index	U047737
Consensus CDS Project	CCDS26010.1
International Mouse Knockout Project Status	Zfp36l1

Sequences

Length	Strain/Species
genomic	12192	NCBI Gene Model | MGI Sequence Detail	5254	C57BL/6J
transcript	NM_007564	RefSeq | MGI Sequence Detail	2984	C57BL/6
polypeptide	P23950	UniProt | EBI | MGI Sequence Detail	338	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(7 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007635	Tis11B-like protein, N-terminal
InterPro	IPR000571	Zinc finger, CCCH-type
Protein Ontology	PR:000017640	Zinc finger protein 36, C3H1 type-like 1

Graphical View of Protein Domain Structure

References

(Earliest) J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
(Latest) J:184831 Uchibe K, et al., Identification of novel transcription-regulating genes expressed during murine molar development. Dev Dyn. 2012 Jul;241(7):1217-26
All references(46)

Other accession IDs

MGD-MRK-36526, MGI:1925964, MGI:2140615, MGI:2145053