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Zfp36l2 Gene Detail
Summary
  • Symbol
    Zfp36l2
  • Name
    zinc finger protein 36, C3H type-like 2
  • Synonyms
    Brf2, ERF2, Tis11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:107945
    NCBI Gene: 12193
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:84183931-84187947 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4017 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.02 cM, cytoband E4
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRF2, ERF2, ERF-2, RNF162C, TIS11D
  • Links
    NCBI Gene ID: 678
    neXtProt AC: NX_P47974
    UniProt: P47974

  • Chr Location
    2p21; chr2:43222402-43226606 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020082 VEGA Gene Model | MGI Sequence Detail 4017 C57BL/6J ±  kb
    transcript OTTMUST00000047765 VEGA | MGI Sequence Detail 3530 Not Applicable  
    polypeptide OTTMUSP00000021700 VEGA | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      24 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 158
      Genomic 1
      cDNA 155
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36525
    References
    more
    • Summaries
      All 48
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 9
    • Earliest
      J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
    • Latest
      J:259588 Newman R, et al., Maintenance of the marginal-zone B cell compartment specifically requires the RNA-binding protein ZFP36L1. Nat Immunol. 2017 Jun;18(6):683-693

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory