Zfp36l2
Gene Detail

Symbol Name ID

Zfp36l2 zinc finger protein 36, C3H type-like 2 MGI:107945

Synonyms

Brf2, ERF2, Tis11d

Feature Type

protein coding gene

Genetic Map

Chromosome 17

55.02 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr17:84183931-84187947 bp, - strand From VEGA annotation of GRCm38   4017 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:5027  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Zfp36l2

Human homologs

Human Homolog		ZFP36L2, ZFP36 ring finger protein-like 2
NCBI Gene ID		678
neXtProt AC		NX_P47974
Human Synonyms		BRF2, ERF2, ERF-2, RNF162C, TIS11D
Human Chr (Location)		2p22.3-p21; chr2:43449541-43453745 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.

 
Human Diseases Modeled Using Mouse Zfp36l2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay, regulation of mRNA stability, ...
Component	cytoplasm, nucleus
Function	DNA binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (15)    Tissues (13)   
Theiler Stages: 2, 3, 4, 5, 28

Assay Type	Results
RT-PCR	15

cDNA source data(153)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(156) Genomic(1) cDNA(154) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020082 (Evidence)
Ensembl Gene Model	ENSMUSG00000045817 (Evidence)
Entrez Gene	12193 (Evidence)
UniGene	259321
DFCI	TC1572375, TC1613893
DoTS	DT.101372403, DT.110563156, DT.94364331
NIA Mouse Gene Index	U038105
Consensus CDS Project	CCDS28998.1
International Mouse Knockout Project Status	Zfp36l2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020082	VEGA Gene Model | MGI Sequence Detail	4017	C57BL/6J
transcript	OTTMUST00000047765	VEGA | MGI Sequence Detail	3530	Not Applicable
polypeptide	OTTMUSP00000021700	VEGA | MGI Sequence Detail	484	Not Applicable

All sequences(39) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(10 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007635	Tis11B-like protein, N-terminal
InterPro	IPR000571	Zinc finger, CCCH-type
Protein Ontology	PR:000017641	butyrate response factor 2

References

(Earliest) J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
(Latest) J:184370 Ramos SB, Characterization of DeltaN-Zfp36l2 mutant associated with arrest of early embryonic development and female infertility. J Biol Chem. 2012 Apr 13;287(16):13116-27
All references(40)

Other accession IDs

MGD-MRK-36525