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Zfp36l2 Gene Detail
Summary
  • Symbol
    Zfp36l2
  • Name
    zinc finger protein 36, C3H type-like 2
  • Synonyms
    Brf2, ERF2, Tis11d
  • Feature Type
    protein coding gene
  • IDs
    MGI:107945
    NCBI Gene: 12193
  • Alliance
  • Transcription Start Sites
    19 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:84183931-84187947 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 55.02 cM, cytoband E4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    24 from dbSNP Build 142
  • Strain Annotations
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107945
protein coding gene Chr17:84183924-84187947 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024077
protein coding gene Chr17:87322560-87331906 (-)
A/J MGP_AJ_G0024036
protein coding gene Chr17:84572264-84575395 (-)
AKR/J MGP_AKRJ_G0024005
protein coding gene Chr17:85941859-85947994 (-)
BALB/cJ MGP_BALBcJ_G0024037
protein coding gene Chr17:84421705-84426776 (-)
C3H/HeJ MGP_C3HHeJ_G0023802
protein coding gene Chr17:86789896-86794130 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024482
protein coding gene Chr17:90438623-90441565 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021921
protein coding gene Chr17:79780902-79784061 (-)
CAST/EiJ MGP_CASTEiJ_G0023281
protein coding gene Chr17:87558122-87561262 (-)
CBA/J MGP_CBAJ_G0023776
protein coding gene Chr17:94168136-94172630 (-)
DBA/2J MGP_DBA2J_G0023904
protein coding gene Chr17:83059244-83063257 (-)
FVB/NJ MGP_FVBNJ_G0023870
protein coding gene Chr17:82535339-82539870 (-)
LP/J MGP_LPJ_G0023988
protein coding gene Chr17:88085278-88089314 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023898
protein coding gene Chr17:94279205-94283224 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024527
protein coding gene Chr17:86430125-86436102 (-)
PWK/PhJ MGP_PWKPhJ_G0023026
protein coding gene Chr17:82620624-82622941 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022837
protein coding gene Chr17:83225713-83231393 (-)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ZFP36L2, ZFP36 ring finger protein like 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRF2, ERF2, ERF-2, RNF162C, TIS11D
  • Links
    NCBI Gene ID: 678
    neXtProt AC: NX_P47974
    UniProt: P47974

  • Chr Location
    2p21; chr2:43222402-43226606 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    24 phenotypes from 2 alleles in 2 genetic backgrounds
    8 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000045817 Ensembl Gene Model | MGI Sequence Detail 4017 C57BL/6J ±  kb
    transcript ENSMUST00000060366 Ensembl | MGI Sequence Detail 3530 Not Applicable  
    polypeptide ENSMUSP00000050820 Ensembl | MGI Sequence Detail 484 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      Genomic 1
      cDNA 156
      Primer pair 1
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36525
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 14
      Phenotypes 10
    • Earliest
      J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
    • Latest
      J:270578 Dumdie JN, et al., Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell. 2018 Feb 5;44(3):392-402.e7

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/19/2019
    MGI 6.13
    The Jackson Laboratory