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Zfp36l2
Gene Detail
 Symbol
Name
ID
Zfp36l2
zinc finger protein 36, C3H type-like 2
MGI:107945
Synonyms Brf2, ERF2, Tis11d
Feature Type protein coding gene
Genetic Map
Chromosome 17
55.02 cM, cytoband E4
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr17:84183931-84187947 bp, - strand
From VEGA annotation of GRCm38

  4017 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5027  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Zfp36l2

Human
homologs
Human Homolog ZFP36L2, ZFP36 ring finger protein-like 2
NCBI Gene ID 678
neXtProt AC  NX_P47974
Human Synonyms  BRF2, ERF2, ERF-2, RNF162C, TIS11D
Human Chr (Location)  2p22.3-p21; chr2:43222402-43226606 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix )
 
Mice expressing decreased levels of an amino-terminal truncated protein display female infertility whereas mice homozygous for a null allele die within two weeks as a result of hematopoietic system defects.
 
Human Diseases Modeled Using Mouse Zfp36l2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Zfp36l2 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process definitive hemopoiesis, hemopoiesis, ...
Component cytoplasm, nucleus
Function AU-rich element binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (16)    Tissues (14)   
Theiler Stages: 2, 3, 4, 5, 21, 28
Assay TypeResults
RNA in situ 1
RT-PCR 15
cDNA source data(154)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(158) Genomic(1) cDNA(155) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020082 (Evidence)
Ensembl Gene ModelENSMUSG00000045817 (Evidence)
Entrez Gene12193 (Evidence)
UniGene259321
DFCITC1572375, TC1613893
DoTSDT.101372403, DT.110563156, DT.94364331
NIA Mouse Gene IndexU038105
Consensus CDS ProjectCCDS28998.1
International Mouse Knockout Project StatusZfp36l2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020082 VEGA Gene Model | MGI Sequence Detail 4017 C57BL/6J ±  kb
transcript OTTMUST00000047765 VEGA | MGI Sequence Detail 3530 Not Applicable 
polypeptide OTTMUSP00000021700 VEGA | MGI Sequence Detail 484 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(24 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007635 Tis11B-like protein, N-terminal
InterPro IPR000571 Zinc finger, CCCH-type
Protein Ontology PR:000017641 zinc finger protein 36, C3H1 type-like 2
References (Earliest) J:33288 Varnum BC, et al., The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat. Mol Cell Biol. 1991 Mar;11(3):1754-8
(Latest) J:199080 Zhang L, et al., ZFP36L2 is required for self-renewal of early burst-forming unit erythroid progenitors. Nature. 2013 Jul 4;499(7456):92-6
All references(42)
Other
accession IDs
MGD-MRK-36525

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory