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Emp1 Gene Detail
Summary
  • Symbol
    Emp1
  • Name
    epithelial membrane protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107941
    NCBI Gene: 13730
  • Alliance
    genome feature page
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:135339548-135360171 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 66.25 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    683 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107941
 protein coding gene Chr6:135339543-135360171 (+)
129S1/SvImJ ENSMUSG00200029451
 protein coding gene Chr6:132832481-132853273 (+)
A/J ENSMUSG00195029598
 protein coding gene Chr6:131685524-131706311 (+)
AKR/J ENSMUSG00220036596
 protein coding gene Chr6:129909979-129930762 (+)
BALB/cJ ENSMUSG00180032768
 protein coding gene Chr6:131765041-131785815 (+)
C3H/HeJ ENSMUSG00175032723
 protein coding gene Chr6:131705847-131726635 (+)
C57BL/6NJ ENSMUSG00215020102
 protein coding gene Chr6:131962477-131983114 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028993
 protein coding gene Chr6:133346867-133367432 (+)
CAST/EiJ ENSTCUG00005039031
 protein coding gene Chr6:132631488-132652128 (+)
CBA/J ENSMUSG00210015648
 protein coding gene Chr6:131724257-131745053 (+)
DBA/2J ENSMUSG00185022058
 protein coding gene Chr6:132420502-132441291 (+)
FVB/NJ ENSMUSG00205022443
 protein coding gene Chr6:130859443-130880227 (+)
JF1/MsJ ENSUMUG00000026388
 protein coding gene Chr6:131178865-131199495 (+)
LP/J ENSMUSG00230006059
 protein coding gene Chr6:133628308-133649091 (+)
NOD/ShiLtJ ENSMUSG00190006229
 protein coding gene Chr6:132258711-132279493 (+)
NZO/HlLtJ ENSMUSG00225007311
 protein coding gene Chr6:136492459-136513262 (+)
PWK/PhJ ENSLUMG00010038914
 protein coding gene Chr6:130232720-130253555 (+)
SPRET/EiJ ENSMSPG00010032997
 protein coding gene Chr6:134024483-134044921 (+)
WSB/EiJ ENSIUOG00005039796
 protein coding gene Chr6:132527487-132548286 (+)



Homology
more
  • Human Ortholog
    EMP1, epithelial membrane protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EMP1, epithelial membrane protein 1
  • Synonyms
    CL-20, EMP-1, TMP
  • Links
    NCBI Gene ID: 2012
    UniProt: P54849

  • Chr Location
    12p13.1; chr12:13196723-13219941 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    14 phenotype references
Homozygous mice do not exhibit an overt mutant phenotype in any parameter tested.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    661
  • Tissues
    51
  • cDNA Data
    171
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 13730 NCBI Gene Model | MGI Sequence Detail 20624 C57BL/6J ±  kb
transcript NM_001288628 RefSeq | MGI Sequence Detail 2832 ZRU/MplStud  
polypeptide P47801 UniProt | EBI | MGI Sequence Detail 160 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 180
    Genomic 7
    cDNA 171
    Primer pair 1
    Other 1
    Antibodies 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36521
References
more
  • Summaries
    All 51
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:29910 Taylor V, et al., Epithelial membrane protein-1, peripheral myelin protein 22, and lens membrane protein 20 define a novel gene family. J Biol Chem. 1995 Dec 1;270(48):28824-33
  • Latest
    J:366215 Rudat C, et al., PPARG contributes to urothelial integrity in the murine ureter by activating the expression of Shh and superficial cell-specific genes. Development. 2025 Apr 15;152(8)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory