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Tfb2m Gene Detail
Summary
  • Symbol
    Tfb2m
  • Name
    transcription factor B2, mitochondrial
  • Synonyms
    Hkp1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107937
    NCBI Gene: 15278
  • Gene Overview
    MyGene.info: TFB2M
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:179528055-179546267 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 83.56 cM, cytoband H3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107937
protein coding gene Chr1:179528052-179546305 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016859
protein coding gene Chr1:185893687-185913997 (-)
A/J MGP_AJ_G0016837
protein coding gene Chr1:178413364-178432439 (-)
AKR/J MGP_AKRJ_G0016803
protein coding gene Chr1:183730363-183748467 (-)
BALB/cJ MGP_BALBcJ_G0016795
protein coding gene Chr1:179034995-179053207 (-)
C3H/HeJ MGP_C3HHeJ_G0016620
protein coding gene Chr1:184459755-184479202 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017259
protein coding gene Chr1:191903515-191935512 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014966
protein coding gene Chr1:169405452-169425242 (-)
CAST/EiJ MGP_CASTEiJ_G0016201
protein coding gene Chr1:183766135-183785565 (-)
CBA/J MGP_CBAJ_G0016594
protein coding gene Chr1:199065640-199088576 (-)
DBA/2J MGP_DBA2J_G0016700
protein coding gene Chr1:177249461-177268356 (-)
FVB/NJ MGP_FVBNJ_G0016696
protein coding gene Chr1:175328475-175347583 (-)
LP/J MGP_LPJ_G0016774
protein coding gene Chr1:187171543-187191240 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016727
protein coding gene Chr1:206216077-206236645 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017295
protein coding gene Chr1:183448564-183468227 (-)
PWK/PhJ MGP_PWKPhJ_G0015989
protein coding gene Chr1:176331877-176350229 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015765
protein coding gene Chr1:182412176-182430279 (-)
WSB/EiJ MGP_WSBEiJ_G0016264
protein coding gene Chr1:183685218-183703388 (-)



Homology
more
  • Human Ortholog
    TFB2M, transcription factor B2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TFB2M, transcription factor B2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Hkp1, mtTFB2
  • Links
    NCBI Gene ID: 64216
    neXtProt AC: NX_Q9H5Q4
    UniProt: Q9H5Q4

  • Chr Location
    1q44; chr1:246540561-246566263 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026492 Ensembl Gene Model | MGI Sequence Detail 18213 C57BL/6J ±  kb
transcript ENSMUST00000027769 Ensembl | MGI Sequence Detail 2449 Not Applicable  
polypeptide ENSMUSP00000027769 Ensembl | MGI Sequence Detail 396 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • EC
  • InterPro Domains
    IPR016861 Mitochondrial transcription factor TFB2
    IPR020598 Ribosomal RNA adenine methylase transferase, N-terminal
    IPR001737 Ribosomal RNA adenine methyltransferase KsgA/Erm
    IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
Molecular
Reagents
less
  • All nucleic 77
    cDNA 73
    Primer pair 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36517
References
more
  • Summaries
    All 39
    Developmental Gene Expression 6
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:256448 Nicholas LM, et al., Mitochondrial transcription factor B2 is essential for mitochondrial and cellular function in pancreatic beta-cells. Mol Metab. 2017 Jul;6(7):651-663

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory