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Mns1
Gene Detail
Symbol

Name
ID
Mns1
meiosis-specific nuclear structural protein 1
MGI:107933
Feature Type
protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:72438011-72459199 bp, + strand
From VEGA annotation of GRCm38

  21189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MNS1
Gene Tree: Mns1

Human
homologs
MNS1, meiosis-specific nuclear structural 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 55329
neXtProt AC: NX_Q8NEH6

Human Synonyms: SPATA40

Human Chr (Location): 15q21.3; chr15:56428731-56465137 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null mutation display partial lethality, male infertility, sperm flagellum abnormalities, immotile sperm, randomized left-right patterning, hydroencephaly, and motile cilia abnormalities.
 
Interactions
Mns1 interacts with 61 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cilium organization, left/right axis specification, ...
Component axoneme, intermediate filament, ...
Function identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 46
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase mns1 ; ZFIN mns1    NEW 
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000044713 (Evidence)
Ensembl Gene Model ENSMUSG00000032221 (Evidence)
Entrez Gene 17427 (Evidence)
UniGene 387671
DFCI TC1583303
NIA Mouse Gene Index U010719
Consensus CDS Project CCDS40684.1
International Mouse Phenotyping Consortium Status Mns1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044713 VEGA Gene Model | MGI Sequence Detail 21189 C57BL/6J ±  kb
transcript OTTMUST00000117577 VEGA | MGI Sequence Detail 2424 Not Applicable 
polypeptide OTTMUSP00000065723 VEGA | MGI Sequence Detail 491 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026504 Meiosis-specific nuclear structural protein 1
Protein Ontology PR:000010499 meiosis-specific nuclear structural protein 1
References
(Earliest) J:19855 Furukawa K, et al., cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 1994 Mar;2(2):99-113
(Latest) J:183398 Zhou J, et al., MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet. 2012 Mar;8(3):e1002516
All references(28)
Other
accession IDs
MGD-MRK-36513, MGI:2143316

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory