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Mns1
Gene Detail
 Symbol
Name
ID
Mns1
meiosis-specific nuclear structural protein 1
MGI:107933
Feature Type protein coding gene
Genetic Map
Chromosome 9
40.08 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:72438011-72459199 bp, + strand
From VEGA annotation of GRCm38

  21189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:40628  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mns1

Human
homologs
Human Homolog MNS1, meiosis-specific nuclear structural 1
NCBI Gene ID 55329
neXtProt AC  NX_Q8NEH6
Human Synonyms  SPATA40
Human Chr (Location)  15q21.3; chr15:56428731-56465137 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display partial lethality, male infertility, sperm flagellum abnormalities, immotile sperm, randomized left-right patterning, hydroencephaly, and motile cilia abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cilium organization, left/right axis specification, ...
Component axoneme, intermediate filament, ...
Function identical protein binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (46)    Tissues (45)    Images (1)
Theiler Stages: 23, 28
Assay TypeResults
RT-PCR 46
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(40) cDNA(39) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000044713 (Evidence)
Ensembl Gene ModelENSMUSG00000032221 (Evidence)
Entrez Gene17427 (Evidence)
UniGene387671
DFCITC1583303
NIA Mouse Gene IndexU010719
Consensus CDS ProjectCCDS40684.1
International Mouse Knockout Project StatusMns1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044713 VEGA Gene Model | MGI Sequence Detail 21189 C57BL/6J ±  kb
transcript OTTMUST00000117577 VEGA | MGI Sequence Detail 2424 Not Applicable 
polypeptide OTTMUSP00000065723 VEGA | MGI Sequence Detail 491 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(187 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026504 Meiosis-specific nuclear structural protein 1
Protein Ontology PR:000010499 meiosis-specific nuclear structural protein 1
References (Earliest) J:19855 Furukawa K, et al., cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 1994 Mar;2(2):99-113
(Latest) J:183398 Zhou J, et al., MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet. 2012 Mar;8(3):e1002516
All references(29)
Other
accession IDs
MGD-MRK-36513, MGI:2143316

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory