About   Help   FAQ
Mns1 Gene Detail
Summary
  • Symbol
    Mns1
  • Name
    meiosis-specific nuclear structural protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107933
    NCBI Gene: 17427
Location & Maps
more
  • Sequence Map
    Chr9:72438011-72462025 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24015 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 40.08 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MNS1, meiosis specific nuclear structural 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MNS1, meiosis specific nuclear structural 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SPATA40
  • Links
    NCBI Gene ID: 55329
    neXtProt AC: NX_Q8NEH6

  • Chr Location
    15q21.3; chr15:56428731-56465137 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 40628
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: MNS1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 1 allele in 1 genetic background
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Mns1
  • Incidental Mutations
Mice homozygous for a null mutation display partial lethality, male infertility, sperm flagellum abnormalities, immotile sperm, randomized left-right patterning, hydroencephaly, and motile cilia abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000044713 VEGA Gene Model | MGI Sequence Detail 24015 C57BL/6J ±  kb
transcript OTTMUST00000117577 VEGA | MGI Sequence Detail 5250 Not Applicable  
polypeptide OTTMUSP00000065723 VEGA | MGI Sequence Detail 491 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    216 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010499 meiosis-specific nuclear structural protein 1
  • InterPro Domains
    IPR026504 Meiosis-specific nuclear structural protein 1
Molecular
Reagents
less
  • All nucleic 41
    cDNA 40
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36513, MGI:2143316
References
more
  • Summaries
    All 26
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 5
  • Earliest
    J:19855 Furukawa K, et al., cDNA cloning and functional characterization of a meiosis-specific protein (MNS1) with apparent nuclear association. Chromosome Res. 1994 Mar;2(2):99-113
  • Latest
    J:183398 Zhou J, et al., MNS1 is essential for spermiogenesis and motile ciliary functions in mice. PLoS Genet. 2012 Mar;8(3):e1002516

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/20/2016
MGI 6.05
The Jackson Laboratory