Ndufs6
Gene Detail

Symbol Name ID

Ndufs6 NADH dehydrogenase (ubiquinone) Fe-S protein 6 MGI:107932

Synonyms

IP13

Feature Type

protein coding gene

Genetic Map

Chromosome 13

39.69 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:73319838-73328542 bp, - strand From VEGA annotation of GRCm38   8705 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37935  Vertebrate Homology Class
1 human; 2 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase [ubiquinone] (complex I), iron-sulfur protein 6, mitochondrial type
Gene Tree: Ndufs6

Human homologs

Human Homolog		NDUFS6, NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NCBI Gene ID		4726
neXtProt AC		NX_O75380
Human Synonyms		CI-13kA, CI-13kD-A, CI13KDA
Human Chr (Location)		5p15.33; chr5:1801496-1816165 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human NDUFS6

Alleles and phenotypes

All alleles(43) : Targeted(2) Gene trapped(41)
 

Mice homozygous for a hypomorph allele display premature death asscoiated with rapid weight loss and cardiac failure. These mice have enlarged hearts with impaired function and mitochondrial abnormalities.

 
Human Diseases Modeled Using Mouse Ndufs6 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cardiovascular system development, electron transport chain, ...
Component	membrane, mitochondrial inner membrane, ...
Function	molecular_function

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (6)
Theiler Stages: 22

Assay Type	Results
RNA in situ	94

cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(2)

Other database links

VEGA Gene Model	OTTMUSG00000030547 (Evidence)
Ensembl Gene Model	ENSMUSG00000021606 (Evidence)
Entrez Gene	407785 (Evidence)
UniGene	29897
DFCI	TC1575378, TC1638989
DoTS	DT.101273756, DT.101289220, DT.97411217
Consensus CDS Project	CCDS26630.1
International Mouse Knockout Project Status	Ndufs6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000030547	VEGA Gene Model | MGI Sequence Detail	8705	C57BL/6J
transcript	OTTMUST00000075615	VEGA | MGI Sequence Detail	568	Not Applicable
polypeptide	OTTMUSP00000039679	VEGA | MGI Sequence Detail	116	Not Applicable

All sequences(34) RefSeq(3) UniProt(3)

Polymorphisms

SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016668	NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria
InterPro	IPR019401	Zinc finger, CHCC-type
Protein Ontology	PR:000011101	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

References

(Earliest) J:36029 Watson JD, et al., Genomic sequence, structural organization and evolutionary conservation of the 13.2-kDa subunit of rat NADH:ubiquinone oxidoreductase. Gene. 1995 Jun 9;158(2):275-80
(Latest) J:183619 Ke BX, et al., Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6165-70
All references(33)

Other accession IDs

MGD-MRK-36512, MGI:3039560