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Ndufs6 Gene Detail
Summary
  • Symbol
    Ndufs6
  • Name
    NADH:ubiquinone oxidoreductase core subunit S6
  • Synonyms
    IP13
  • Feature Type
    protein coding gene
  • IDs
    MGI:107932
    NCBI Gene: 407785
  • Gene Overview
    MyGene.info: NDUFS6
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:73319876-73328482 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 39.69 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    54 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107932
protein coding gene Chr13:73319838-73328542 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020743
protein coding gene Chr13:73750476-73761356 (-)
A/J MGP_AJ_G0020699
protein coding gene Chr13:71136850-71145510 (-)
AKR/J MGP_AKRJ_G0020673
protein coding gene Chr13:73369320-73377981 (-)
BALB/cJ MGP_BALBcJ_G0020696
protein coding gene Chr13:71628409-71637075 (-)
C3H/HeJ MGP_C3HHeJ_G0020490
protein coding gene Chr13:73054665-73063329 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021133
protein coding gene Chr13:76212326-76220981 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018700
protein coding gene Chr13:67944821-67953512 (-)
CAST/EiJ MGP_CASTEiJ_G0020007
protein coding gene Chr13:72128131-72136968 (-)
CBA/J MGP_CBAJ_G0020449
protein coding gene Chr13:79072643-79081296 (-)
DBA/2J MGP_DBA2J_G0020574
protein coding gene Chr13:70958034-70967177 (-)
FVB/NJ MGP_FVBNJ_G0020554
protein coding gene Chr13:69982578-69991249 (-)
LP/J MGP_LPJ_G0020647
protein coding gene Chr13:74013697-74022376 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020582
protein coding gene Chr13:77514492-77523132 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021172
protein coding gene Chr13:72679149-72687826 (-)
PWK/PhJ MGP_PWKPhJ_G0019761
protein coding gene Chr13:69683710-69692590 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019584
protein coding gene Chr13:69145185-69153308 (-)
WSB/EiJ MGP_WSBEiJ_G0020065
protein coding gene Chr13:73230072-73238720 (-)



Homology
more
  • Human Ortholog
    NDUFS6, NADH:ubiquinone oxidoreductase subunit S6
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NDUFS6, NADH:ubiquinone oxidoreductase subunit S6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CI-13kA, CI-13kD-A, CI13KDA
  • Links
    NCBI Gene ID: 4726
    neXtProt AC: NX_O75380
    UniProt: O75380

  • Chr Location
    5p15.33; chr5:1801382-1816051 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Ndufs6 mouse models; 1 with human NDUFS6 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 1 allele in 1 genetic background
    2 images
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorph allele display premature death asscoiated with rapid weight loss and cardiac failure. These mice have enlarged hearts with impaired function and mitochondrial abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 407785 NCBI Gene Model | MGI Sequence Detail 8607 C57BL/6J ±  kb
    transcript NR_033306 RefSeq | MGI Sequence Detail 587 C57BL/6  
    polypeptide P52503 UniProt | EBI | MGI Sequence Detail 116 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000011101 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
    • PDB
    • InterPro Domains
      IPR016668 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
      IPR019401 Zinc finger, CHCC-type
    Molecular
    Reagents
    less
    • All nucleic 84
      Genomic 1
      cDNA 83

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36512, MGI:3039560
    References
    more
    • Summaries
      All 36
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 6
      Phenotypes 10
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:244992 Gomez-Velazquez M, et al., CTCF counter-regulates cardiomyocyte development and maturation programs in the embryonic heart. PLoS Genet. 2017 Aug;13(8):e1006985

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory