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Ndufs6
Gene Detail
 Symbol
Name
ID
Ndufs6
NADH dehydrogenase (ubiquinone) Fe-S protein 6
MGI:107932
Synonyms IP13
Feature Type protein coding gene
Genetic Map
Chromosome 13
39.69 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:73319874-73328542 bp, - strand
From VEGA annotation of GRCm38

  8669 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37935  Vertebrate Homology Class
1 human; 2 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: NADH dehydrogenase [ubiquinone] (complex I), iron-sulfur protein 6, mitochondrial type
Gene Tree: Ndufs6

Human
homologs
Human Homolog NDUFS6, NADH dehydrogenase (ubiquinone) Fe-S protein 6, 13kDa (NADH-coenzyme Q reductase)
NCBI Gene ID 4726
neXtProt AC  NX_O75380
Human Synonyms  CI-13kA, CI-13kD-A, CI13KDA
Human Chr (Location)  5p15.33; chr5:1801382-1816051 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human NDUFS6
Mutations,
alleles, and
phenotypes
All mutations/alleles(43) : Gene trapped(41) Targeted(2)
 
Mice homozygous for a hypomorph allele display premature death asscoiated with rapid weight loss and cardiac failure. These mice have enlarged hearts with impaired function and mitochondrial abnormalities.
 
Human Diseases Modeled Using Mouse Ndufs6 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cardiovascular system development, fatty acid metabolic process, ...
Component membrane, mitochondrial inner membrane, ...
Function molecular_function
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (94)    Tissues (94)    Images (6)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(82)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000030547 (Evidence)
Ensembl Gene ModelENSMUSG00000021606 (Evidence)
Entrez Gene407785 (Evidence)
UniGene29897
DFCITC1575378, TC1638989
DoTSDT.101273756, DT.101289220, DT.97411217
Consensus CDS ProjectCCDS26630.1
International Mouse Knockout Project StatusNdufs6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030547 VEGA Gene Model | MGI Sequence Detail 8669 C57BL/6J ±  kb
transcript OTTMUST00000075615 VEGA | MGI Sequence Detail 568 Not Applicable 
polypeptide OTTMUSP00000039679 VEGA | MGI Sequence Detail 116 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(3) UniProt(2)
Polymorphisms SNPs within 2kb(54 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016668 NADH dehydrogenase [ubiquinone] (complex I), iron-sulphur protein 6, mitochondria
InterPro IPR019401 Zinc finger, CHCC-type
Protein Ontology PR:000011101 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial
References (Earliest) J:36029 Watson JD, et al., Genomic sequence, structural organization and evolutionary conservation of the 13.2-kDa subunit of rat NADH:ubiquinone oxidoreductase. Gene. 1995 Jun 9;158(2):275-80
(Latest) J:183619 Ke BX, et al., Tissue-specific splicing of an Ndufs6 gene-trap insertion generates a mitochondrial complex I deficiency-specific cardiomyopathy. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6165-70
All references(33)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36512, MGI:3039560

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory