About   Help   FAQ
Wnt8a
Gene Detail
Symbol

Name
ID
Wnt8a
wingless-type MMTV integration site family, member 8A
MGI:107924
Synonyms
Stra11
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.69 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:34542313-34548273 bp, + strand
From Ensembl annotation of GRCm38

  5961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: WNT8A
Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8a

Human
homologs
WNT8A, wingless-type MMTV integration site family, member 8A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7478
neXtProt AC: NX_Q9H1J5

Human Synonyms: WNT8D

Human Chr (Location): 5q31; chr5:138083892-138096730 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile.
 
Interactions
Wnt8a interacts with 58 markers (Mir15a, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell fate commitment, cell morphogenesis, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (57 records)
Data Summary: Results (491)    Tissues (440)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 466
RT-PCR 23
RNase protection 2
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA WNT8A ; Xenbase wnt8a    NEW 
Molecular
reagents
All nucleic(26) cDNA(15) Primer pair(8) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000012282 (Evidence)
Entrez Gene 20890 (Evidence)
UniGene 558
DFCI TC1595915
DoTS DT.40157754, DT.94226319
NIA Mouse Gene Index U018541
Consensus CDS Project CCDS29129.1
International Mouse Phenotyping Consortium Status Wnt8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000012282 Ensembl Gene Model | MGI Sequence Detail 5961 C57BL/6J ±  kb
transcript ENSMUST00000012426 Ensembl | MGI Sequence Detail 1746 Not Applicable 
polypeptide ENSMUSP00000012426 Ensembl | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013301 Wnt-8 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017450 protein Wnt-8a
References
(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:222431 Cunningham TJ, et al., Wnt8a and Wnt3a cooperate in the axial stem cell niche to promote mammalian body axis extension. Dev Dyn. 2015 Jun;244(6):797-807
All references(84)
Other
accession IDs
MGD-MRK-36504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory