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Wnt8a
Gene Detail
Symbol

Name
ID
Wnt8a
wingless-type MMTV integration site family, member 8A
MGI:107924
Synonyms
Stra11
Feature Type
protein coding gene
Genetic Map
Chromosome 18
18.69 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:34542313-34548273 bp, + strand
From Ensembl annotation of GRCm38

  5961 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8a

Human
homologs
Human Homolog WNT8A, wingless-type MMTV integration site family, member 8A
NCBI Gene ID 7478
neXtProt AC  NX_Q9H1J5
Human Synonyms  WNT8D
Human Chr (Location)  5q31; chr5:138083892-138092648 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are viable and fertile.
 
Interactions
Wnt8a interacts with 58 markers (Mir15a, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process cell fate commitment, cell morphogenesis, ...
Component extracellular region, extracellular space, ...
Function frizzled binding, protein binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (55 records)
Data Summary: Results (491)    Tissues (440)    Images (55)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 466
RT-PCR 23
RNase protection 2
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(15) Primer pair(8) Other(3)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000012282 (Evidence)
Entrez Gene20890 (Evidence)
UniGene558
DFCITC1595915
DoTSDT.94226319, DT.40157754
NIA Mouse Gene IndexU018541
Consensus CDS ProjectCCDS29129.1
International Mouse Knockout Project StatusWnt8a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000012282 Ensembl Gene Model | MGI Sequence Detail 5961 C57BL/6J ±  kb
transcript ENSMUST00000012426 Ensembl | MGI Sequence Detail 1746 Not Applicable 
polypeptide ENSMUSP00000012426 Ensembl | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005817 Wnt
InterPro IPR013301 Wnt-8 protein
InterPro IPR018161 Wnt protein, conserved site
Protein Ontology PR:000017450 protein Wnt-8a
References
(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:214093 Cambier L, et al., Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3. Development. 2014 Aug;141(15):2959-71
All references(84)
Other
accession IDs
MGD-MRK-36504

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory