Wnt8a
Gene Detail

Symbol Name ID

Wnt8a wingless-related MMTV integration site 8A MGI:107924

Synonyms

Stra11

Feature Type

protein coding gene

Genetic Map

Chromosome 18

18.69 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:34542328-34548061 bp, + strand From NCBI annotation of GRCm38   5734 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7553  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: int-1 transforming protein
Gene Tree: Wnt8a

Human homologs

Human Homolog		WNT8A, wingless-type MMTV integration site family, member 8A
NCBI Gene ID		7478
neXtProt AC		NX_Q9H1J5
Human Synonyms		WNT8D
Human Chr (Location)		5q31; chr5:137419774-137427199 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

Mice homozygous for a knock-out allele are viable and fertile.

 

Gene Ontology (GO) classifications

All GO classifications: (20 annotations)

Process	cell fate commitment, cell morphogenesis, ...
Component	extracellular region, extracellular space, ...
Function	frizzled binding, protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (49 records)
Data Summary: Results (222)    Tissues (189)    Images (37)
Theiler Stages: 5, 8, 9, 11, 12, 13, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	210
RT-PCR	10
RNase protection	2

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(14) Primer pair(7) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000012282 (Evidence)
Entrez Gene	20890 (Evidence)
UniGene	558
DFCI	TC1595915
DoTS	DT.40157754, DT.94226319
NIA Mouse Gene Index	U018541
Consensus CDS Project	CCDS29129.1
International Mouse Knockout Project Status	Wnt8a

Sequences

Length	Strain/Species
genomic	20890	NCBI Gene Model | MGI Sequence Detail	5734	C57BL/6J
transcript	NM_009290	RefSeq | MGI Sequence Detail	1519	C57BL/6
polypeptide	Q64527	UniProt | EBI | MGI Sequence Detail	354	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(26 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR005817	Wnt
InterPro	IPR013301	Wnt-8 protein
InterPro	IPR018161	Wnt protein, conserved site
Protein Ontology	PR:000017450	protein Wnt-8a

Graphical View of Protein Domain Structure

References

(Earliest) J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
(Latest) J:194132 Vendrell V, et al., Roles of Wnt8a during formation and patterning of the mouse inner ear. Mech Dev. 2013 Feb;130(2-3):160-8
All references(79)

Other accession IDs

MGD-MRK-36504