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Nfyc Gene Detail
Summary
  • Symbol
    Nfyc
  • Name
    nuclear transcription factor-Y gamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:107901
    NCBI Gene: 18046
  • Gene Overview
    MyGene.info: NFYC
Location & Maps
more
  • Sequence Map
    Chr4:120757438-120831572 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74135 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 56.52 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NFYC, nuclear transcription factor Y subunit gamma
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFYC, nuclear transcription factor Y subunit gamma
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CBFC, CBF-C, H1TF2A, HAP5, HSM, NF-YC
  • Links
    NCBI Gene ID: 4802
    neXtProt AC: NX_Q13952

  • Chr Location
    1p32; chr1:40691570-40771603 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7440
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NFYC
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotype references
  • All Mutations and Alleles
    420
  • Chemically induced (other)
    2
  • Gene trapped
    415
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Nfyc
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008852 VEGA Gene Model | MGI Sequence Detail 74135 C57BL/6J ±  kb
transcript OTTMUST00000020128 VEGA | MGI Sequence Detail 1932 Not Applicable  
polypeptide OTTMUSP00000009230 VEGA | MGI Sequence Detail 335 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    251 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    6 Sequences
  • InterPro Domains
    IPR009072 Histone-fold
    IPR027170 Transcriptional activator NFYC/HAP5 subunit
    IPR003958 Transcription factor CBF/NF-Y/archaeal histone domain
Molecular
Reagents
less
  • All nucleic 14
    cDNA 12
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36480
References
more
  • Summaries
    All 43
    Developmental Gene Expression 6
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:36015 Sinha S, et al., Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. Genomics. 1996 Oct 15;37(2):260-3
  • Latest
    J:218809 Castro NE, et al., Transforming growth factor beta1 (TGF-beta1) enhances expression of profibrotic genes through a novel signaling cascade and microRNAs in renal mesangial cells. J Biol Chem. 2014 Oct 17;289(42):29001-13

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory