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Tubb2a Gene Detail
Summary
  • Symbol
    Tubb2a
  • Name
    tubulin, beta 2A class IIA
  • Feature Type
    protein coding gene
  • IDs
    MGI:107861
    NCBI Gene: 22151
  • Gene Overview
    MyGene.info: TUBB2A
Location & Maps
more
  • Sequence Map
    Chr13:34074301-34078008 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3708 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 14.03 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    TUBB2A, tubulin beta 2A class IIa
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TUBB2A, tubulin beta 2A class IIa
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDCBM5, TUBB, TUBB2
  • Links
    NCBI Gene ID: 7280
    neXtProt AC: NX_Q13885

  • Chr Location
    6p25.2; chr6:3153666-3157549 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TUBB2A associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 5; CDCBM5   OMIM: 615763
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    1
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Tubb2a
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058672 Ensembl Gene Model | MGI Sequence Detail 3708 C57BL/6J ±  kb
transcript ENSMUST00000056427 Ensembl | MGI Sequence Detail 1584 Not Applicable  
polypeptide ENSMUSP00000060246 Ensembl | MGI Sequence Detail 445 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    48 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 184
    cDNA 182
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36438
References
more
  • Summaries
    All 39
    Developmental Gene Expression 13
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:19085 Lewis SA, et al., Five mouse tubulin isotypes and their regulated expression during development. J Cell Biol. 1985 Sep;101(3):852-61
  • Latest
    J:231463 Haque K, et al., MEKK4 Signaling Regulates Sensory Cell Development and Function in the Mouse Inner Ear. J Neurosci. 2016 Jan 27;36(4):1347-61

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory