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Gpr18 Gene Detail
Summary
  • Symbol
    Gpr18
  • Name
    G protein-coupled receptor 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:107859
    NCBI Gene: 110168
  • Gene Overview
    MyGene.info: GPR18
Location & Maps
more
  • Sequence Map
    Chr14:121911435-121915774 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4340 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 65.86 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GPR18, G protein-coupled receptor 18
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR18, G protein-coupled receptor 18
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2841
    neXtProt AC: NX_Q14330

  • Chr Location
    13q32; chr13:99254713-99262448 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    2 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
  • Incidental Mutations
    APF
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000050350 Ensembl Gene Model | MGI Sequence Detail 4340 C57BL/6J ±  kb
transcript ENSMUST00000055475 Ensembl | MGI Sequence Detail 1309 Not Applicable  
polypeptide ENSMUSP00000061410 Ensembl | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001430 N-arachidonyl glycine receptor
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR028335 G protein-coupled receptor 18 orphan
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
less
  • All nucleic 15
    Genomic 1
    cDNA 14

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36436
References
more
  • Summaries
    All 22
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:37412 Samuelson LC, et al., Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14. Mamm Genome. 1996 Dec;7(12):920-1
  • Latest
    J:219661 Wang X, et al., GPR18 is required for a normal CD8alphaalpha intestinal intraepithelial lymphocyte compartment. J Exp Med. 2014 Nov 17;211(12):2351-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory