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Gpr18 Gene Detail
Summary
  • Symbol
    Gpr18
  • Name
    G protein-coupled receptor 18
  • Feature Type
    protein coding gene
  • IDs
    MGI:107859
    NCBI Gene: 110168
  • Gene Overview
    MyGene.info: GPR18
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:121911434-121915774 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4341 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 65.86 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    GPR18, G protein-coupled receptor 18
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR18, G protein-coupled receptor 18
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 2841
    neXtProt AC: NX_Q14330
    UniProt: Q14330

  • Chr Location
    13q32.3; chr13:99254713-99262498 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a reduction in CD8-positive, alpha-beta T cell number and CD8-positive, gamma-delta intraepithelial T cell number. Mice homozygous for a different knock-out allele exhibit increased susceptibility to E. coli infection and diminished response to RvD2.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 110168 NCBI Gene Model | MGI Sequence Detail 4341 C57BL/6J ±  kb
transcript NM_182806 RefSeq | MGI Sequence Detail 1334 C57BL/6  
polypeptide Q8K1Z6 UniProt | EBI | MGI Sequence Detail 331 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    45 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    Genomic 1
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36436
References
more
  • Summaries
    All 27
    Gene Ontology 4
    Phenotypes 4
  • Earliest
    J:37412 Samuelson LC, et al., Mapping of the novel G protein-coupled receptor Gpr18 to distal mouse chromosome 14. Mamm Genome. 1996 Dec;7(12):920-1
  • Latest
    J:254677 Miller S, et al., Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure. Invest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6419-6426

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/11/2018
MGI 6.12
The Jackson Laboratory