Dgcr14
Gene Detail

Symbol Name ID

Dgcr14 DiGeorge syndrome critical region gene 14 MGI:107854

Synonyms

D16H22S1269E, Dgsi, ES2, Es2el

Feature Type

protein coding gene

Genetic Map

Chromosome 16

11.09 cM, cytoband B1-B3
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr16:17900711-17911348 bp, - strand From Ensembl annotation of GRCm38   10638 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:11184  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Protein DGCR14
Gene Tree: Dgcr14

Human homologs

Human Homolog		DGCR14, DiGeorge syndrome critical region gene 14
NCBI Gene ID		8220
neXtProt AC		NX_Q96DF8
Human Synonyms		DGCR13, DGSH, DGS-H, DGSI, DGS-I, ES2, Es2el
Human Chr (Location)		22q11.21; chr22:19117792-19132190 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DGCR14

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	mRNA processing, RNA splicing
Component	catalytic step 2 spliceosome, nucleus, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (76)    Tissues (55)    Images (17)
Theiler Stages: 16, 17, 19, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	35
RT-PCR	41

cDNA source data(78)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(108) Genomic(27) cDNA(78) Primer pair(3)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000003527 (Evidence)
Entrez Gene	27886 (Evidence)
UniGene	256480
DFCI	TC1575477
DoTS	DT.110730636, DT.531450
NIA Mouse Gene Index	U036851
Consensus CDS Project	CCDS28013.1
International Mouse Knockout Project Status	Dgcr14

Sequences

Length	Strain/Species
genomic	ENSMUSG00000003527	Ensembl Gene Model | MGI Sequence Detail	10638	C57BL/6J
transcript	ENSMUST00000003621	Ensembl | MGI Sequence Detail	2819	Not Applicable
polypeptide	ENSMUSP00000003621	Ensembl | MGI Sequence Detail	480	Not Applicable

All sequences(31) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(37 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR019148	Nuclear protein DGCR14
Protein Ontology	PR:000006437	protein DGCR14

References

(Earliest) J:15242 Halford S, et al., Isolation of a gene expressed during early embryogenesis from the region of 22q11 commonly deleted in DiGeorge syndrome. Hum Mol Genet. 1993 Oct;2(10):1577-82
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-36431, MGI:2146439, MGI:892008