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Ccr4 Gene Detail
Summary
  • Symbol
    Ccr4
  • Name
    chemokine (C-C motif) receptor 4
  • Synonyms
    CC CKR-4, Cmkbr4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107824
    NCBI Gene: 12773
  • Gene Overview
    MyGene.info: CCR4
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:114490316-114504916 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 64.49 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107824
protein coding gene Chr9:114490316-114505484 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035388
protein coding gene Chr9:116919937-116927987 (-)
A/J MGP_AJ_G0035368
protein coding gene Chr9:112648462-112654313 (-)
AKR/J MGP_AKRJ_G0035301
protein coding gene Chr9:115507482-115513631 (-)
BALB/cJ MGP_BALBcJ_G0035364
protein coding gene Chr9:112445863-112451960 (-)
C3H/HeJ MGP_C3HHeJ_G0035072
protein coding gene Chr9:116020569-116026336 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035887
protein coding gene Chr9:120120146-120127277 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032770
protein coding gene Chr9:109948002-109953604 (-)
CAST/EiJ MGP_CASTEiJ_G0034377
protein coding gene Chr9:115859744-115866101 (-)
CBA/J MGP_CBAJ_G0035039
protein coding gene Chr9:124604383-124613600 (-)
DBA/2J MGP_DBA2J_G0035198
protein coding gene Chr9:112126883-112133923 (-)
FVB/NJ MGP_FVBNJ_G0035145
protein coding gene Chr9:110939126-110944833 (-)
LP/J MGP_LPJ_G0035277
protein coding gene Chr9:117269755-117276999 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035186
protein coding gene Chr9:125857957-125864149 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035906
protein coding gene Chr9:115878183-115886664 (-)
PWK/PhJ MGP_PWKPhJ_G0034083
protein coding gene Chr9:112420698-112428644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033917
protein coding gene Chr9:115931396-115936877 (-)
WSB/EiJ MGP_WSBEiJ_G0034497
protein coding gene Chr9:115759844-115765571 (-)



Homology
more
  • Human Ortholog
    CCR4, C-C motif chemokine receptor 4
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CCR4, C-C motif chemokine receptor 4
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5
  • Links
    NCBI Gene ID: 1233
    neXtProt AC: NX_P51679
    UniProt: P51679

  • Chr Location
    3p22.3; chr3:32951555-32955312 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 2 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000047898 Ensembl Gene Model | MGI Sequence Detail 14601 C57BL/6J ±  kb
    transcript ENSMUST00000054414 Ensembl | MGI Sequence Detail 2805 Not Applicable  
    polypeptide ENSMUSP00000062677 Ensembl | MGI Sequence Detail 360 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 15
      Primer pair 1
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36401, MGD-MRK-37445
    References
    more
    • Summaries
      All 91
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:30657 Hoogewerf A, et al., Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996 Jan 5;218(1):337-43
    • Latest
      J:264370 Sima J, et al., Eda-activated RelB recruits an SWI/SNF (BAF) chromatin-remodeling complex and initiates gene transcription in skin appendage formation. Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):8173-8178

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory