About   Help   FAQ
Ccr4
Gene Detail
Symbol

Name
ID
Ccr4
chemokine (C-C motif) receptor 4
MGI:107824
Synonyms
CC CKR-4, Cmkbr4
Feature Type
protein coding gene
Genetic Map
Chromosome 9
64.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:114490316-114496544 bp, - strand
From Ensembl annotation of GRCm38

  6229 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: CCR4
Protein SuperFamily: chemokine receptor
Gene Tree: Ccr4

Human
homologs
CCR4, chemokine (C-C motif) receptor 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1233
neXtProt AC: NX_P51679

Human Synonyms: CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5

Human Chr (Location): 3p24; chr3:32951574-32954911 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration.
 
Interactions
Ccr4 interacts with 187 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (156)    Tissues (87)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 105
RT-PCR 46
RNase protection 5
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(14) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000047898 (Evidence)
Entrez Gene 12773 (Evidence)
UniGene 1337
DFCI TC1594904
DoTS DT.87039138, DT.87051340
NIA Mouse Gene Index U031395
Consensus CDS Project CCDS23594.1
International Mouse Phenotyping Consortium Status Ccr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000047898 Ensembl Gene Model | MGI Sequence Detail 6229 C57BL/6J ±  kb
transcript ENSMUST00000054414 Ensembl | MGI Sequence Detail 2787 Not Applicable 
polypeptide ENSMUSP00000062677 Ensembl | MGI Sequence Detail 360 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(10) UniProt(1)
Polymorphisms
RFLP(2) : SNPs within 2kb(46 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002239 CC chemokine receptor 4
InterPro IPR000355 Chemokine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001200 C-C chemokine receptor type 4
References
(Earliest) J:30657 Hoogewerf A, et al., Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996 Jan 5;218(1):337-43
(Latest) J:206301 Stolberg VR, et al., Role of CC chemokine receptor 4 in natural killer cell activation during acute cigarette smoke exposure. Am J Pathol. 2014 Feb;184(2):454-63
All references(76)
Other
accession IDs
MGD-MRK-36401, MGD-MRK-37445

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory