Ccr4
Gene Detail

Symbol Name ID

Ccr4 chemokine (C-C motif) receptor 4 MGI:107824

Synonyms

CC CKR-4, Cmkbr4

Feature Type

protein coding gene

Genetic Map

Chromosome 9

64.49 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:114490316-114496544 bp, - strand From NCBI annotation of GRCm38   6229 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21135  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: chemokine receptor
Gene Tree: Ccr4

Human homologs

Human Homolog		CCR4, chemokine (C-C motif) receptor 4
NCBI Gene ID		1233
neXtProt AC		NX_P51679
Human Synonyms		CC-CKR-4, CD194, ChemR13, CKR4, CMKBR4, HGCN:14099, K5-5
Human Chr (Location)		3p24; chr3:32993066-32996403 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous mutation of this gene results in decreased mortality, decreased tumor necrosis factor production, and decreased IL-1beta production following LPS administration.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	chemokine-mediated signaling pathway, chemotaxis, ...
Component	external side of plasma membrane, integral to membrane, ...
Function	C-C chemokine binding, C-C chemokine receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (156)    Tissues (87)    Images (30)
Theiler Stages: 13, 19, 20, 23, 28

Assay Type	Results
RNA in situ	105
RT-PCR	46
RNase protection	5

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(14) Primer pair(1) Other(2)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000047898 (Evidence)
Entrez Gene	12773 (Evidence)
UniGene	1337
DFCI	TC1594904
DoTS	DT.87039138, DT.87051340
NIA Mouse Gene Index	U031395
Consensus CDS Project	CCDS23594.1
International Mouse Knockout Project Status	Ccr4

Sequences

Length	Strain/Species
genomic	12773	NCBI Gene Model | MGI Sequence Detail	6229	C57BL/6J
transcript	NM_009916	RefSeq | MGI Sequence Detail	2787	Not Specified
polypeptide	P51680	UniProt | EBI | MGI Sequence Detail	360	Not Applicable

All sequences(15) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(2) : SNPs(31 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002239	CC chemokine receptor, type 4
InterPro	IPR000355	Chemokine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001200	C-C chemokine receptor type 4

Graphical View of Protein Domain Structure

References

(Earliest) J:30657 Hoogewerf A, et al., Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996 Jan 5;218(1):337-43
(Latest) J:182145 Poppensieker K, et al., CC chemokine receptor 4 is required for experimental autoimmune encephalomyelitis by regulating GM-CSF and IL-23 production in dendritic cells. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3897-902
All references(74)

Other accession IDs

MGD-MRK-36401, MGD-MRK-37445