Ctsk
Gene Detail

Symbol Name ID

Ctsk cathepsin K MGI:107823

Synonyms

catK, Cat K

Feature Type

protein coding gene

Genetic Map

Chromosome 3

40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr3:95499286-95509362 bp, + strand From NCBI annotation of GRCm38   10077 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:68053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsk

Human homologs

Human Homolog		CTSK, cathepsin K
NCBI Gene ID		1513
neXtProt AC		NX_P43235
Human Synonyms		CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
Human Chr (Location)		1q21; chr1:150768684-150780917 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CTSK

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Mice homozygous for disruptions in this gene survive well and are fertile. They have osteopetrosis, reduced levels of thyroxine and increased pulmonary fibrosis.

 
Human Diseases Modeled Using Mouse Ctsk (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	bone resorption, proteolysis
Component	cytoplasm, extracellular space, ...
Function	cysteine-type peptidase activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (112)    Tissues (67)    Images (13)
Theiler Stages: 18, 19, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	52
Northern blot	42
Western blot	2
RT-PCR	16

cDNA source data(89)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(94) Genomic(2) cDNA(89) Primer pair(3)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000028111 (Evidence)
Entrez Gene	13038 (Evidence)
UniGene	272085
DFCI	TC1577820
DoTS	DT.533942
NIA Mouse Gene Index	U003570
EC	3.4.22.38
Consensus CDS Project	CCDS17615.1
International Mouse Knockout Project Status	Ctsk

Sequences

Length	Strain/Species
genomic	13038	NCBI Gene Model | MGI Sequence Detail	10077	C57BL/6J
transcript	NM_007802	RefSeq | MGI Sequence Detail	1482	C57BL/6
polypeptide	P55097	UniProt | EBI | MGI Sequence Detail	329	Not Applicable

All sequences(17) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(90 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000169	Cysteine peptidase, cysteine active site
InterPro	IPR025660	Cysteine peptidase, histidine active site
InterPro	IPR015644	Peptidase C1A, cathepsin K
InterPro	IPR013128	Peptidase C1A, papain
InterPro	IPR000668	Peptidase C1A, papain C-terminal
InterPro	IPR013201	Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology	PR:000001850	cathepsin K

Graphical View of Protein Domain Structure

References

(Earliest) J:35370 Rantakokko J, et al., Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996 Sep 16;393(2-3):307-13
(Latest) J:194359 Yang C, et al., Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Cancer Discov. 2013 Feb;3(2):212-23
All references(89)

Other accession IDs

MGD-MRK-36400, MGI:2139671