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Ctsk Gene Detail
Summary
  • Symbol
    Ctsk
  • Name
    cathepsin K
  • Synonyms
    catK, Cat K
  • Feature Type
    protein coding gene
  • IDs
    MGI:107823
    NCBI Gene: 13038
  • Gene Overview
    MyGene.info: CTSK
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:95499256-95509362 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    100 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107823
protein coding gene Chr3:95499210-95509387 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027585
protein coding gene Chr3:96232169-96249997 (+)
A/J MGP_AJ_G0027544
protein coding gene Chr3:93247452-93257436 (+)
AKR/J MGP_AKRJ_G0027511
protein coding gene Chr3:95418288-95428287 (+)
BALB/cJ MGP_BALBcJ_G0027556
protein coding gene Chr3:93027826-93037856 (+)
C3H/HeJ MGP_C3HHeJ_G0027289
protein coding gene Chr3:95706142-95717437 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028004
protein coding gene Chr3:99797787-99809616 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025344
protein coding gene Chr3:89580750-89591354 (+)
CAST/EiJ MGP_CASTEiJ_G0026739
protein coding gene Chr3:94968595-94984816 (+)
CBA/J MGP_CBAJ_G0027266
protein coding gene Chr3:103447190-103459288 (+)
DBA/2J MGP_DBA2J_G0027405
protein coding gene Chr3:92534601-92544603 (+)
FVB/NJ MGP_FVBNJ_G0027376
protein coding gene Chr3:90613058-90623291 (+)
LP/J MGP_LPJ_G0027514
protein coding gene Chr3:97548307-97558172 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027403
protein coding gene Chr3:109550181-109562193 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028058
protein coding gene Chr3:95056345-95066343 (+)
PWK/PhJ MGP_PWKPhJ_G0026467
protein coding gene Chr3:92419087-92429583 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026288
protein coding gene Chr3:93341236-93353025 (+)
WSB/EiJ MGP_WSBEiJ_G0026821
protein coding gene Chr3:95446188-95456694 (+)



Homology
more
  • Human Ortholog
    CTSK, cathepsin K
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSK, cathepsin K
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
  • Links
    NCBI Gene ID: 1513
    neXtProt AC: NX_P43235
    UniProt: P43235

  • Chr Location
    1q21.3; chr1:150796208-150808441 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 68053
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;2 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CTSK
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human CTSK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 10 genetic backgrounds
    46 phenotypes from multigenic genotypes
    9 images
    87 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene survive well and are fertile. They have osteopetrosis, reduced levels of thyroxine and increased pulmonary fibrosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028111 Ensembl Gene Model | MGI Sequence Detail 10107 C57BL/6J ±  kb
    transcript ENSMUST00000015664 Ensembl | MGI Sequence Detail 1512 Not Applicable  
    polypeptide ENSMUSP00000015664 Ensembl | MGI Sequence Detail 329 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 96
      Genomic 2
      cDNA 91
      Primer pair 3

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36400, MGI:2139671
    References
    more
    • Summaries
      All 157
      Developmental Gene Expression 22
      Diseases 2
      Gene Ontology 7
      Phenotypes 87
    • Earliest
      J:35370 Rantakokko J, et al., Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996 Sep 16;393(2-3):307-13
    • Latest
      J:266619 Yang P, et al., Preservation of type H vessels and osteoblasts by enhanced preosteoclast platelet-derived growth factor type BB attenuates glucocorticoid-induced osteoporosis in growing mice. Bone. 2018 Sep;114:1-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory