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Ctsk Gene Detail
Summary
  • Symbol
    Ctsk
  • Name
    cathepsin K
  • Synonyms
    catK, Cat K
  • Feature Type
    protein coding gene
  • IDs
    MGI:107823
    NCBI Gene: 13038
  • Gene Overview
    MyGene.info: CTSK
Location & Maps
more
  • Sequence Map
    Chr3:95499256-95509362 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10107 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 40.74 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    CTSK, cathepsin K
  • Vertebrate Orthologs
    11
  • Human Ortholog
    CTSK, cathepsin K
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
  • Links
    NCBI Gene ID: 1513
    neXtProt AC: NX_P43235

  • Chr Location
    1q21; chr1:150796208-150808441 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 68053
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;2 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CTSK
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Ctsk mouse models; 1 with human CTSK associations

Human Disease Mouse Models
       Pycnodysostosis   OMIM: 265800 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 6 alleles in 10 genetic backgrounds
    40 phenotypes from multigenic genotypes
    9 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    10
  • Genomic Mutations
    2 involving Ctsk
  • Incidental Mutations
Mice homozygous for disruptions in this gene survive well and are fertile. They have osteopetrosis, reduced levels of thyroxine and increased pulmonary fibrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053004 VEGA Gene Model | MGI Sequence Detail 10107 C57BL/6J ±  kb
transcript OTTMUST00000132593 VEGA | MGI Sequence Detail 1512 Not Applicable  
polypeptide OTTMUSP00000070676 VEGA | MGI Sequence Detail 329 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    100 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 95
    Genomic 2
    cDNA 90
    Primer pair 3

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-36400, MGI:2139671
References
more
  • Summaries
    All 118
    Developmental Gene Expression 15
    Diseases 4
    Gene Ontology 5
    Phenotypes 67
  • Earliest
    J:35370 Rantakokko J, et al., Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996 Sep 16;393(2-3):307-13
  • Latest
    J:228674 Sumiya E, et al., Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation. Biochem Biophys Res Commun. 2015 Aug 7;463(4):1284-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory