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Ctsk
Gene Detail
 Symbol
Name
ID
Ctsk
cathepsin K
MGI:107823
Synonyms catK, Cat K
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:95499286-95509362 bp, + strand
From NCBI annotation of GRCm38

  10077 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Ctsk

Human
homologs
Human Homolog CTSK, cathepsin K
NCBI Gene ID 1513
neXtProt AC  NX_P43235
Human Synonyms  CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD
Human Chr (Location)  1q21; chr1:150796208-150808441 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human CTSK
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene survive well and are fertile. They have osteopetrosis, reduced levels of thyroxine and increased pulmonary fibrosis.
 
Human Diseases Modeled Using Mouse Ctsk (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(6)
Interactions
Ctsk interacts with 101 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process bone resorption, collagen catabolic process, ...
Component cytoplasm, extracellular space, ...
Function collagen binding, cysteine-type endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (112)    Tissues (67)    Images (13)
Theiler Stages: 18, 19, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 52
Northern blot 42
Western blot 2
RT-PCR 16
cDNA source data(89)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(94) Genomic(2) cDNA(89) Primer pair(3)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000028111 (Evidence)
Entrez Gene13038 (Evidence)
UniGene272085
DFCITC1577820
DoTSDT.533942
NIA Mouse Gene IndexU003570
EC3.4.22.38
Consensus CDS ProjectCCDS17615.1
International Mouse Knockout Project StatusCtsk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13038 NCBI Gene Model | MGI Sequence Detail 10077 C57BL/6J ±  kb
transcript NM_007802 RefSeq | MGI Sequence Detail 1583 C57BL/6 
polypeptide P55097 UniProt | EBI | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(102 from dbSNP Build 137)    SNPs within 2kb including multiple locations(106)
Protein-related
information
ResourceIDDescription
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR015644 Peptidase C1A, cathepsin K
InterPro IPR013128 Peptidase C1A, papain
InterPro IPR000668 Peptidase C1A, papain C-terminal
InterPro IPR013201 Proteinase inhibitor I29, cathepsin propeptide
Protein Ontology PR:000001850 cathepsin K
Graphical View of Protein Domain Structure
References (Earliest) J:35370 Rantakokko J, et al., Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996 Sep 16;393(2-3):307-13
(Latest) J:208357 Hirose J, et al., Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast. J Exp Med. 2014 Jan 13;211(1):153-63
All references(103)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-36400, MGI:2139671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory