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Ctsk
Gene Detail
Symbol

Name
ID
Ctsk
cathepsin K
MGI:107823
Synonyms
catK, Cat K
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr3:95499256-95509362 bp, + strand
From VEGA annotation of GRCm38

  10107 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68053  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: CTSK
Gene Tree: Ctsk

Human
homologs
CTSK, cathepsin K
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1513
neXtProt AC: NX_P43235

Human Synonyms: CTS02, CTSO, CTSO1, CTSO2, PKND, PYCD

Human Chr (Location): 1q21; chr1:150796208-150808441 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CTSK

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Targeted(10)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene survive well and are fertile. They have osteopetrosis, reduced levels of thyroxine and increased pulmonary fibrosis.
 
Human Diseases Modeled in Mice Using Ctsk (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(6)
Interactions
Ctsk interacts with 101 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process bone resorption, collagen catabolic process, ...
Component cytoplasm, extracellular space, ...
Function collagen binding, cysteine-type endopeptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (15 records)
Data Summary: Results (143)    Tissues (90)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 52
Northern blot 63
Western blot 2
RT-PCR 16
cDNA source data(89)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ctsk ; ZFIN ctsk    NEW 
Molecular
reagents
All nucleic(95) Genomic(2) cDNA(90) Primer pair(3)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000053004 (Evidence)
Ensembl Gene Model ENSMUSG00000028111 (Evidence)
Entrez Gene 13038 (Evidence)
UniGene 272085
DFCI TC1577820
DoTS DT.533942
NIA Mouse Gene Index U003570
EC 3.4.22.38
Consensus CDS Project CCDS17615.1
International Mouse Phenotyping Consortium Status Ctsk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000053004 VEGA Gene Model | MGI Sequence Detail 10107 C57BL/6J ±  kb
transcript OTTMUST00000132593 VEGA | MGI Sequence Detail 1512 Not Applicable 
polypeptide OTTMUSP00000070676 VEGA | MGI Sequence Detail 329 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(102 from dbSNP Build 137)    SNPs within 2kb including multiple locations(106)
Protein-related
information
ResourceIDDescription
InterPro IPR013201 Cathepsin propeptide inhibitor domain (I29)
InterPro IPR000169 Cysteine peptidase, cysteine active site
InterPro IPR025660 Cysteine peptidase, histidine active site
InterPro IPR013128 Peptidase C1A
InterPro IPR015644 Peptidase C1A, cathepsin K
InterPro IPR000668 Peptidase C1A, papain C-terminal
Protein Ontology PR:000001850 cathepsin K
References
(Earliest) J:35370 Rantakokko J, et al., Mouse cathepsin K: cDNA cloning and predominant expression of the gene in osteoclasts, and in some hypertrophying chondrocytes during mouse development. FEBS Lett. 1996 Sep 16;393(2-3):307-13
(Latest) J:222030 Hua Y, et al., Cathepsin K knockout alleviates aging-induced cardiac dysfunction. Aging Cell. 2015 Jun;14(3):345-51
All references(115)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-36400, MGI:2139671

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory