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Has2 Gene Detail
Summary
  • Symbol
    Has2
  • Name
    hyaluronan synthase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107821
    NCBI Gene: 15117
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:56529023-56557935 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 23.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107821
protein coding gene Chr15:56529023-56557942 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021859
protein coding gene Chr15:55808709-55839837 (-)
A/J MGP_AJ_G0021819
protein coding gene Chr15:53573357-53602517 (-)
AKR/J MGP_AKRJ_G0021800
protein coding gene Chr15:55109154-55138284 (-)
BALB/cJ MGP_BALBcJ_G0021826
protein coding gene Chr15:53806846-53836274 (-)
C3H/HeJ MGP_C3HHeJ_G0021600
protein coding gene Chr15:55193237-55224456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022265
protein coding gene Chr15:57929060-57965651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019802
protein coding gene Chr15:50758525-50785918 (-)
CAST/EiJ MGP_CASTEiJ_G0021117
protein coding gene Chr15:55810875-55842971 (-)
CBA/J MGP_CBAJ_G0021569
protein coding gene Chr15:59955369-59992052 (-)
DBA/2J MGP_DBA2J_G0021693
protein coding gene Chr15:53485332-53514737 (-)
FVB/NJ MGP_FVBNJ_G0021671
protein coding gene Chr15:52581198-52609741 (-)
LP/J MGP_LPJ_G0021763
protein coding gene Chr15:55600444-55633500 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021695
protein coding gene Chr15:65038583-65070264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022288
protein coding gene Chr15:55487139-55517998 (-)
PWK/PhJ MGP_PWKPhJ_G0020862
protein coding gene Chr15:53537044-53566923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020699
protein coding gene Chr15:55261549-55291055 (-)
WSB/EiJ MGP_WSBEiJ_G0021172
protein coding gene Chr15:55451500-55482071 (-)



Homology
more
  • Human Ortholog
    HAS2, hyaluronan synthase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HAS2, hyaluronan synthase 2
  • Links
    NCBI Gene ID: 3037
    neXtProt AC: NX_Q92819
    UniProt: Q92819

  • Chr Location
    8q24.13; chr8:121612116-121641440 (-)  GRCh38

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    51 phenotypes from 5 alleles in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    3 images
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die during midgestation with severe defects in yolk sac and systemic vasculature, including pericardial edema, compaction of the extracellular space, and absence of endocardial cushions and trabeculae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022367 Ensembl Gene Model | MGI Sequence Detail 28913 C57BL/6J ±  kb
    transcript ENSMUST00000050544 Ensembl | MGI Sequence Detail 4237 Not Applicable  
    polypeptide ENSMUSP00000062212 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      cDNA 33
      Primer pair 10
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36398
    References
    more
    • Summaries
      All 140
      Developmental Gene Expression 56
      Diseases 2
      Gene Ontology 10
      Phenotypes 48
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:345073 Eley L, et al., eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling. Dis Model Mech. 2024 Jan 1;17(1)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory