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Has2
Gene Detail
 Symbol
Name
ID
Has2
hyaluronan synthase 2
MGI:107821
Feature Type protein coding gene
Genetic Map
Chromosome 15
23.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:56665627-56694539 bp, - strand
From VEGA annotation of GRCm38

  28913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3892  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Has2

Human
homologs
Human Homolog HAS2, hyaluronan synthase 2
NCBI Gene ID 3037
neXtProt AC  NX_Q92819
Human Chr (Location)  8q24.12; chr8:121613031-121641390 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation die during midgestation with severe defects in yolk sac and systemic vasculature, including pericardial edema, compaction of the extracellular space, and absence of endocardial cushions and trabeculae.
 
Phenotype Images(3)
Interactions
Has2 interacts with 393 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process atrioventricular canal development, bone morphogenesis, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function hyaluronan synthase activity, transferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (139)    Tissues (131)    Images (24)
Theiler Stages: 11, 12, 14, 16, 17, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
RNA in situ 121
Northern blot 11
RT-PCR 7
cDNA source data(27)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(29) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000036745 (Evidence)
Ensembl Gene ModelENSMUSG00000022367 (Evidence)
Entrez Gene15117 (Evidence)
UniGene5148
DFCITC1580681
NIA Mouse Gene IndexU036189
EC2.4.1.212
Consensus CDS ProjectCCDS27480.1
International Mouse Knockout Project StatusHas2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036745 VEGA Gene Model | MGI Sequence Detail 28913 C57BL/6J ±  kb
transcript OTTMUST00000094254 VEGA | MGI Sequence Detail 4237 Not Applicable 
polypeptide OTTMUSP00000052379 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001173 Glycosyl transferase, family 2
InterPro IPR026107 Hyaluronan synthase/nodulation protein C
Protein Ontology PR:000008450 hyaluronan synthase 2
References (Earliest) J:33034 Semino CE, et al., Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4548-53
(Latest) J:210601 Arranz AM, et al., Hyaluronan deficiency due to Has3 knock-out causes altered neuronal activity and seizures via reduction in brain extracellular space. J Neurosci. 2014 Apr 30;34(18):6164-76
All references(66)
Other
accession IDs
MGD-MRK-36398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory