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Has2 Gene Detail
Summary
  • Symbol
    Has2
  • Name
    hyaluronan synthase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107821
    NCBI Gene: 15117
  • Gene Overview
    MyGene.info: HAS2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:56665627-56694539 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 23.31 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    194 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107821
protein coding gene Chr15:56665627-56694546 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021859
protein coding gene Chr15:55808709-55839837 (-)
A/J MGP_AJ_G0021819
protein coding gene Chr15:53573357-53602517 (-)
AKR/J MGP_AKRJ_G0021800
protein coding gene Chr15:55109154-55138284 (-)
BALB/cJ MGP_BALBcJ_G0021826
protein coding gene Chr15:53806846-53836274 (-)
C3H/HeJ MGP_C3HHeJ_G0021600
protein coding gene Chr15:55193237-55224456 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022265
protein coding gene Chr15:57929060-57965651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019802
protein coding gene Chr15:50758525-50785918 (-)
CAST/EiJ MGP_CASTEiJ_G0021117
protein coding gene Chr15:55810875-55842971 (-)
CBA/J MGP_CBAJ_G0021569
protein coding gene Chr15:59955369-59992052 (-)
DBA/2J MGP_DBA2J_G0021693
protein coding gene Chr15:53485332-53514737 (-)
FVB/NJ MGP_FVBNJ_G0021671
protein coding gene Chr15:52581198-52609741 (-)
LP/J MGP_LPJ_G0021763
protein coding gene Chr15:55600444-55633500 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021695
protein coding gene Chr15:65038583-65070264 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022288
protein coding gene Chr15:55487139-55517998 (-)
PWK/PhJ MGP_PWKPhJ_G0020862
protein coding gene Chr15:53537044-53566923 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020699
protein coding gene Chr15:55261549-55291055 (-)
WSB/EiJ MGP_WSBEiJ_G0021172
protein coding gene Chr15:55451500-55482071 (-)



Homology
more
  • Human Ortholog
    HAS2, hyaluronan synthase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAS2, hyaluronan synthase 2
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 3037
    neXtProt AC: NX_Q92819
    UniProt: Q92819

  • Chr Location
    8q24.13; chr8:121613031-121641390 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3892
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HAS2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    39 phenotypes from 6 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die during midgestation with severe defects in yolk sac and systemic vasculature, including pericardial edema, compaction of the extracellular space, and absence of endocardial cushions and trabeculae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022367 Ensembl Gene Model | MGI Sequence Detail 28913 C57BL/6J ±  kb
    transcript ENSMUST00000050544 Ensembl | MGI Sequence Detail 4237 Not Applicable  
    polypeptide ENSMUSP00000062212 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 32
      Primer pair 6
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36398
    References
    more
    • Summaries
      All 100
      Developmental Gene Expression 34
      Diseases 2
      Gene Ontology 9
      Phenotypes 29
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:264434 Majors AK, et al., Nitric oxide alters hyaluronan deposition by airway smooth muscle cells. PLoS One. 2018;13(7):e0200074

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory