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Has2
Gene Detail
Symbol

Name
ID
Has2
hyaluronan synthase 2
MGI:107821
Feature Type
protein coding gene
Genetic Map
Chromosome 15
23.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:56665627-56694539 bp, - strand
From VEGA annotation of GRCm38

  28913 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3892  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HAS2
Gene Tree: Has2

Human
homologs
HAS2, hyaluronan synthase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3037
neXtProt AC: NX_Q92819

Human Chr (Location): 8q24.12; chr8:121612116-121641390 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(11) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation die during midgestation with severe defects in yolk sac and systemic vasculature, including pericardial edema, compaction of the extracellular space, and absence of endocardial cushions and trabeculae.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Has2 interacts with 393 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (27 records)
Data Summary: Results (139)    Tissues (131)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
Northern blot 11
RT-PCR 7
cDNA source data(27)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HAS2 ; Xenbase has2 ; ZFIN has2    NEW 
Molecular
reagents
All nucleic(33) cDNA(29) Primer pair(4)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000036745 (Evidence)
Ensembl Gene Model ENSMUSG00000022367 (Evidence)
Entrez Gene 15117 (Evidence)
UniGene 5148
DFCI TC1580681
NIA Mouse Gene Index U036189
EC 2.4.1.212
Consensus CDS Project CCDS27480.1
International Mouse Phenotyping Consortium Status Has2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036745 VEGA Gene Model | MGI Sequence Detail 28913 C57BL/6J ±  kb
transcript OTTMUST00000094254 VEGA | MGI Sequence Detail 4237 Not Applicable 
polypeptide OTTMUSP00000052379 VEGA | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(19) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(194 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001173 Glycosyltransferase 2-like
InterPro IPR028371 Hyaluronan synthase 2
InterPro IPR026107 Hyaluronan synthase/nodulation protein C
InterPro IPR029044 Nucleotide-diphospho-sugar transferases
Protein Ontology PR:000008450 hyaluronan synthase 2
References
(Earliest) J:33034 Semino CE, et al., Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4548-53
(Latest) J:222450 Uribe V, et al., Arid3b is essential for second heart field cell deployment and heart patterning. Development. 2014 Nov;141(21):4168-81
All references(71)
Other
accession IDs
MGD-MRK-36398

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory