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Has2 Gene Detail
Summary
  • Symbol
    Has2
  • Name
    hyaluronan synthase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107821
    NCBI Gene: 15117
Location & Maps
more
  • Sequence Map
    Chr15:56665627-56694539 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28913 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    HAS2, hyaluronan synthase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HAS2, hyaluronan synthase 2
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 3037
    neXtProt AC: NX_Q92819

  • Chr Location
    8q24.12; chr8:121612116-121641390 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3892
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: HAS2
  • Gene Tree
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 6 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    3
  • Radiation induced
    1
  • Targeted
    11
  • Transgenic
    2
  • Genomic Mutations
    4 involving Has2
  • Incidental Mutations
Mice homozygous for a targeted mutation die during midgestation with severe defects in yolk sac and systemic vasculature, including pericardial edema, compaction of the extracellular space, and absence of endocardial cushions and trabeculae.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036745 VEGA Gene Model | MGI Sequence Detail 28913 C57BL/6J ±  kb
transcript OTTMUST00000094254 VEGA | MGI Sequence Detail 4237 Not Applicable  
polypeptide OTTMUSP00000052379 VEGA | MGI Sequence Detail 552 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    194 from dbSNP Build 137
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 29
    Primer pair 4
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36398
References
more
  • Summaries
    All 71
    Developmental Gene Expression 28
    Diseases 2
    Gene Ontology 8
    Phenotypes 26
  • Earliest
    J:33034 Semino CE, et al., Homologs of the Xenopus developmental gene DG42 are present in zebrafish and mouse and are involved in the synthesis of Nod-like chitin oligosaccharides during early embryogenesis. Proc Natl Acad Sci U S A. 1996 May 14;93(10):4548-53
  • Latest
    J:218040 Rock K, et al., miR-23a-3p Causes Cellular Senescence by Targeting Hyaluronan Synthase 2: Possible Implication for Skin Aging. J Invest Dermatol. 2015 Feb;135(2):369-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory