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Pfkfb1 Gene Detail
Summary
  • Symbol
    Pfkfb1
  • Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Synonyms
    PFK-2/FBPase-2 gene A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107816
    NCBI Gene: 18639
  • Gene Overview
    MyGene.info: PFKFB1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:150588258-150643878 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband F2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    285 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107816
protein coding gene ChrX:150588229-150643878 (.)
129S1/SvImJ MGP_129S1SvImJ_G0036170
protein coding gene ChrX:148321109-148372262 (+)
A/J MGP_AJ_G0036146
protein coding gene ChrX:147527505-147574019 (+)
AKR/J MGP_AKRJ_G0036072
protein coding gene ChrX:152313545-152357659 (+)
BALB/cJ MGP_BALBcJ_G0036137
protein coding gene ChrX:145723724-145771485 (+)
C3H/HeJ MGP_C3HHeJ_G0035845
protein coding gene ChrX:148514337-148566205 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036662
protein coding gene ChrX:152483479-152543704 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033486
protein coding gene ChrX:139366929-139412434 (+)
CAST/EiJ MGP_CASTEiJ_G0035136
protein coding gene ChrX:127962741-128014249 (+)
CBA/J MGP_CBAJ_G0035822
protein coding gene ChrX:157048650-157100713 (+)
DBA/2J MGP_DBA2J_G0035980
protein coding gene ChrX:146623763-146672738 (+)
FVB/NJ MGP_FVBNJ_G0035914
protein coding gene ChrX:145774105-145818770 (+)
LP/J MGP_LPJ_G0036071
protein coding gene ChrX:149377670-149433476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035950
protein coding gene ChrX:165084872-165145717 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036697
protein coding gene ChrX:147827637-147880939 (+)
PWK/PhJ MGP_PWKPhJ_G0034830
protein coding gene ChrX:124945999-124992064 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034656
protein coding gene ChrX:128432951-128483994 (+)
WSB/EiJ MGP_WSBEiJ_G0035271
protein coding gene ChrX:145912636-145964988 (+)



Homology
more
  • Human Ortholog
    PFKFB1, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PFKFB1, 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    F6PK, HL2K, PFRX
  • Links
    NCBI Gene ID: 5207
    neXtProt AC: NX_P16118
    UniProt: P16118

  • Chr Location
    Xp11.21; chrX:54933134-54998534 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18639 NCBI Gene Model | MGI Sequence Detail 55621 C57BL/6J ±  kb
transcript NM_008824 RefSeq | MGI Sequence Detail 1753 C57BL/6  
polypeptide P70266 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36393
References
more
  • Summaries
    All 36
    Developmental Gene Expression 2
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:35365 Batra RS, et al., Molecular cloning and tissue-specific expression of mouse kidney 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. FEBS Lett. 1996 Sep 16;393(2-3):167-73
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory