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Tubb1
Gene Detail
Symbol

Name
ID
Tubb1
tubulin, beta 1 class VI
MGI:107814
Synonyms
2810484G07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
97.95 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:174450695-174457882 bp, + strand
From VEGA annotation of GRCm38

  7188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Tubb1

Human
homologs
Human Homolog TUBB1, tubulin, beta 1 class VI
NCBI Gene ID 81027
neXtProt AC  NX_Q9H4B7
Human Chr (Location)  20q13.32; chr20:59019254-59026654 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TUBB1
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes have thrombocytopenia resulting from a defect in generating proplatelets. The platelets that are produced have structural and functional defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process GTP catabolic process, microtubule-based process, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (26)    Tissues (3)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
cDNA source data(7)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(8) cDNA(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016460 (Evidence)
Ensembl Gene ModelENSMUSG00000016255 (Evidence)
Entrez Gene545486 (Evidence)
UniGene45285
DFCITC1625251, TC1608596
DoTSDT.87047797, DT.101307725
NIA Mouse Gene IndexU023742, U248709
Consensus CDS ProjectCCDS38359.1
International Mouse Knockout Project StatusTubb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016460 VEGA Gene Model | MGI Sequence Detail 7188 C57BL/6J ±  kb
transcript OTTMUST00000039660 VEGA | MGI Sequence Detail 1406 Not Applicable 
polypeptide OTTMUSP00000017700 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016815 tubulin beta-1 chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16
All references(44)
Other
accession IDs
MGD-MRK-36391, MGI:1920067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory