Tubb1
Gene Detail

Symbol Name ID

Tubb1 tubulin, beta 1 class VI MGI:107814

Synonyms

2810484G07Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 2

97.95 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:174450695-174457882 bp, + strand From VEGA annotation of GRCm38   7188 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:69474  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tubb1

Human homologs

Human Homolog		TUBB1, tubulin, beta 1 class VI
NCBI Gene ID		81027
neXtProt AC		NX_Q9H4B7
Human Chr (Location)		20q13.32; chr20:57594309-57601709 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TUBB1

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes have thrombocytopenia resulting from a defect in generating proplatelets. The platelets that are produced have structural and functional defects.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	GTP catabolic process, microtubule-based process, ...
Component	cytoplasm, cytoskeleton, ...
Function	GTPase activity, GTP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (26)    Tissues (3)    Images (24)
Theiler Stages: 20, 23

Assay Type	Results
RNA in situ	26

cDNA source data(4)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(5) cDNA(4) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016460 (Evidence)
Ensembl Gene Model	ENSMUSG00000016255 (Evidence)
Entrez Gene	545486 (Evidence)
DFCI	TC1608596, TC1625251
DoTS	DT.101307725, DT.87047797
NIA Mouse Gene Index	U023742, U248709
Consensus CDS Project	CCDS38359.1
International Mouse Knockout Project Status	Tubb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016460	VEGA Gene Model | MGI Sequence Detail	7188	C57BL/6J
transcript	OTTMUST00000039660	VEGA | MGI Sequence Detail	1406	Not Applicable
polypeptide	OTTMUSP00000017700	VEGA | MGI Sequence Detail	451	Not Applicable

All sequences(25) RefSeq(3) UniProt(1)

Polymorphisms

SNPs(33 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002453	Beta tubulin
InterPro	IPR013838	Beta tubulin, autoregulation binding site
InterPro	IPR000217	Tubulin
InterPro	IPR017975	Tubulin, conserved site
InterPro	IPR023123	Tubulin, C-terminal
InterPro	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain
InterPro	IPR008280	Tubulin/FtsZ, C-terminal
InterPro	IPR003008	Tubulin/FtsZ, GTPase domain
Protein Ontology	PR:000016815	tubulin beta-1 chain

References

(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(40)

Other accession IDs

MGD-MRK-36391, MGI:1920067