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Tubb1
Gene Detail
Symbol

Name
ID
Tubb1
tubulin, beta 1 class VI
MGI:107814
Synonyms
2810484G07Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 2
97.95 cM, cytoband H
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:174450695-174457882 bp, + strand
From VEGA annotation of GRCm38

  7188 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:69474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TUBB1
Gene Tree: Tubb1

Human
homologs
TUBB1, tubulin, beta 1 class VI
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 81027
neXtProt AC: NX_Q9H4B7

Human Chr (Location): 20q13.32; chr20:59019254-59026654 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TUBB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes have thrombocytopenia resulting from a defect in generating proplatelets. The platelets that are produced have structural and functional defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process microtubule-based process, protein polymerization, ...
Component cytoplasm, cytoskeleton, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (26)    Tissues (3)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 26
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA TUBB1    NEW 
Molecular
reagents
All nucleic(8) cDNA(7) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016460 (Evidence)
Ensembl Gene Model ENSMUSG00000016255 (Evidence)
Entrez Gene 545486 (Evidence)
UniGene 45285
DFCI TC1625251, TC1608596
DoTS DT.101307725, DT.87047797
NIA Mouse Gene Index U023742, U248709
Consensus CDS Project CCDS38359.1
International Mouse Phenotyping Consortium Status Tubb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016460 VEGA Gene Model | MGI Sequence Detail 7188 C57BL/6J ±  kb
transcript OTTMUST00000039660 VEGA | MGI Sequence Detail 1406 Not Applicable 
polypeptide OTTMUSP00000017700 VEGA | MGI Sequence Detail 451 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(3) UniProt(1)
Polymorphisms
SNPs within 2kb(68 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016815 tubulin beta-1 chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:201321 Copley CO, et al., Postnatal refinement of auditory hair cell planar polarity deficits occurs in the absence of Vangl2. J Neurosci. 2013 Aug 28;33(35):14001-16
All references(42)
Other
accession IDs
MGD-MRK-36391, MGI:1920067

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory