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Tubb3
Gene Detail
Symbol

Name
ID
Tubb3
tubulin, beta 3 class III
MGI:107813
Synonyms
3200002H15Rik, betaIII-tubulin, Tuj1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:123411424-123422015 bp, + strand
From VEGA annotation of GRCm38

  10592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TUBB3
Gene Tree: Tubb3

Human
homologs
TUBB3, tubulin, beta 3 class III
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10381
neXtProt AC: NX_Q13509

Human Synonyms: beta-4, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4

Human Chr (Location): 16q24.3; chr16:89922009-89936097 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human TUBB3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit neonatal lethality associated with respiratory distress, abnormal corpus callosum morphology, abnormal cranial nerves, and defective axon guidance.
 
Human Diseases Modeled in Mice Using Tubb3 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tubb3 interacts with 55 markers (Mir16-1, Mir26a-2, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process axon guidance, microtubule-based process, ...
Component axon, cell periphery, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1018 records)
Data Summary: Results (553)    Tissues (219)    Images (361)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 431
RNA in situ 81
RT-PCR 41
cDNA source data(130)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA TUBB3 ; Xenbase tubb3    NEW 
Molecular
reagents
All nucleic(139) Genomic(1) cDNA(130) Primer pair(4) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027611 (Evidence)
Ensembl Gene Model ENSMUSG00000062380 (Evidence)
Entrez Gene 22152 (Evidence)
UniGene 40068
DFCI TC1573449
DoTS DT.97349101, DT.50315992
Consensus CDS Project CCDS22757.1
International Mouse Phenotyping Consortium Status Tubb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027611 VEGA Gene Model | MGI Sequence Detail 10592 C57BL/6J ±  kb
transcript OTTMUST00000068344 VEGA | MGI Sequence Detail 1868 Not Applicable 
polypeptide OTTMUSP00000034531 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016819 tubulin beta-3 chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:220860 Magnani D, et al., The ciliogenic transcription factor Rfx3 is required for the formation of the thalamocortical tract by regulating the patterning of prethalamus and ventral telencephalon. Hum Mol Genet. 2015 May 1;24(9):2578-93
All references(1065)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36390, MGI:1914177

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory