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Tubb3
Gene Detail
Symbol

Name
ID
Tubb3
tubulin, beta 3 class III
MGI:107813
Synonyms
3200002H15Rik, betaIII-tubulin
Feature Type
protein coding gene
Genetic Map
Chromosome 8
72.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:123411424-123422015 bp, + strand
From VEGA annotation of GRCm38

  10592 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:68503  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Gene Tree: Tubb3

Human
homologs
Human Homolog TUBB3, tubulin, beta 3 class III
NCBI Gene ID 10381
neXtProt AC  NX_Q13509
Human Synonyms  beta-4, CDCBM, CDCBM1, CFEOM3, CFEOM3A, FEOM3, TUBB4
Human Chr (Location)  16q24.3; chr16:89922009-89936097 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human TUBB3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit neonatal lethality associated with respiratory distress, abnormal corpus callosum morphology, abnormal cranial nerves, and defective axon guidance.
 
Human Diseases Modeled Using Mouse Tubb3 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Tubb3 interacts with 55 markers (Mir16-1, Mir26a-2, Mir34a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process axon guidance, GTP catabolic process, ...
Component axon, cell periphery, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (978 records)
Data Summary: Results (528)    Tissues (213)    Images (357)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 418
RNA in situ 81
RT-PCR 29
cDNA source data(130)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(137) Genomic(1) cDNA(130) Primer pair(2) Other(4)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027611 (Evidence)
Ensembl Gene ModelENSMUSG00000062380 (Evidence)
Entrez Gene22152 (Evidence)
UniGene40068
DFCITC1573449
DoTSDT.97349101, DT.50315992
Consensus CDS ProjectCCDS22757.1
International Mouse Knockout Project StatusTubb3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027611 VEGA Gene Model | MGI Sequence Detail 10592 C57BL/6J ±  kb
transcript OTTMUST00000068344 VEGA | MGI Sequence Detail 1868 Not Applicable 
polypeptide OTTMUSP00000034531 VEGA | MGI Sequence Detail 450 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002453 Beta tubulin
InterPro IPR013838 Beta tubulin, autoregulation binding site
InterPro IPR000217 Tubulin
InterPro IPR017975 Tubulin, conserved site
InterPro IPR023123 Tubulin, C-terminal
InterPro IPR018316 Tubulin/FtsZ, 2-layer sandwich domain
InterPro IPR008280 Tubulin/FtsZ, C-terminal
InterPro IPR003008 Tubulin/FtsZ, GTPase domain
Protein Ontology PR:000016819 tubulin beta-3 chain
References
(Earliest) J:35227 Wang D, et al., The mammalian beta-tubulin repertoire: hematopoietic expression of a novel, heterologous beta-tubulin isotype. J Cell Biol. 1986 Nov;103(5):1903-10
(Latest) J:214739 Glerup S, et al., SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87
All references(1024)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36390, MGI:1914177

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory