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Nptx1 Gene Detail
Summary
  • Symbol
    Nptx1
  • Name
    neuronal pentraxin 1
  • Synonyms
    D11Bwg1004e, Np1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107811
    NCBI Gene: 18164
Location & Maps
more
  • Sequence Map
    Chr11:119538719-119547753 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9035 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NPTX1, neuronal pentraxin I
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NPTX1, neuronal pentraxin I
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NP1
  • Links
    NCBI Gene ID: 4884
    neXtProt AC: NX_Q15818

  • Chr Location
    17q25.3; chr17:80466833-80476604 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1891
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: NPTX1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003985 VEGA Gene Model | MGI Sequence Detail 9035 C57BL/6J ±  kb
transcript OTTMUST00000008850 VEGA | MGI Sequence Detail 5217 Not Applicable  
polypeptide OTTMUSP00000004316 VEGA | MGI Sequence Detail 432 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000011382 neuronal pentraxin-1
  • InterPro Domains
    IPR013320 Concanavalin A-like lectin/glucanase domain
    IPR030476 Pentaxin, conserved site
    IPR001759 Pentaxin-related
Molecular
Reagents
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  • All nucleic 25
    Genomic 1
    cDNA 23
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-34057, MGD-MRK-36388
References
more
  • Summaries
    All 32
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:35528 Omeis IA, et al., Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. Genomics. 1996 Sep 15;36(3):543-5
  • Latest
    J:197498 Al Rahim M, et al., Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury. Neurobiol Dis. 2013 Feb;50:59-68

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory