About   Help   FAQ
Nptx1
Gene Detail
 Symbol
Name
ID
Nptx1
neuronal pentraxin 1
MGI:107811
Synonyms D11Bwg1004e, Np1
Feature Type protein coding gene
Genetic Map
Chromosome 11
83.95 cM, cytoband E1-E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:119538719-119547753 bp, - strand
From VEGA annotation of GRCm38

  9035 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1891  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nptx1

Human
homologs
Human Homolog NPTX1, neuronal pentraxin I
NCBI Gene ID 4884
neXtProt AC  NX_Q15818
Human Synonyms  NP1
Human Chr (Location)  17q25.3; chr17:80466833-80476604 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation of this gene display a mild alteration in retinal ganglion cell innervation but are fertile with no obvious behavioral abnormalities.
 
Interactions
Nptx1 interacts with 384 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process axonogenesis involved in innervation, cellular response to potassium ion, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function metal ion binding
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (151)    Tissues (42)    Images (28)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 151
cDNA source data(23)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(1) cDNA(23) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003985 (Evidence)
Ensembl Gene ModelENSMUSG00000025582 (Evidence)
Entrez Gene18164 (Evidence)
UniGene5142
DFCITC1603342, TC1674831
DoTSDT.55281352
NIA Mouse Gene IndexU033699
Consensus CDS ProjectCCDS25719.1
International Mouse Knockout Project StatusNptx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003985 VEGA Gene Model | MGI Sequence Detail 9035 C57BL/6J ±  kb
transcript OTTMUST00000008850 VEGA | MGI Sequence Detail 5217 Not Applicable 
polypeptide OTTMUSP00000004316 VEGA | MGI Sequence Detail 432 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001759 Pentaxin
Protein Ontology PR:000011382 neuronal pentraxin-1
References (Earliest) J:35528 Omeis IA, et al., Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization. Genomics. 1996 Sep 15;36(3):543-5
(Latest) J:197498 Al Rahim M, et al., Critical role of neuronal pentraxin 1 in mitochondria-mediated hypoxic-ischemic neuronal injury. Neurobiol Dis. 2013 Feb;50:59-68
All references(36)
Other
accession IDs
MGD-MRK-34057, MGD-MRK-36388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory