Atp5b MGI Mouse Gene Detail - MGI:107801 - ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

Atp5b Gene Detail

Symbol

Atp5b
Name

ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit

Feature Type

protein coding gene
IDs

MGI:107801
NCBI Gene: 11947
Gene Overview

MyGene.info: ATP5B

Sequence Map

Chr10:128083273-128090391 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

7119 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.39 cM
Mapping Data

2 experiments

Human Ortholog

ATP5B, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide

Vertebrate Orthologs

10

Human Ortholog

ATP5B, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
Orthology source: HomoloGene, HGNC
Synonyms

ATPMB, ATPSB, HEL-S-271
Links

HGNC:830

NCBI Gene ID: 506

neXtProt AC: NX_P06576
Chr Location

12q13.13; chr12:56638175-56646068 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 1273
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: ATP5B
Protein SuperFamily

ATP synthase subunit beta
Gene Tree

Atp5b

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

31
Gene trapped

26
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC

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All GO Annotations

43
GO References

10

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

139
Tissues

125
cDNA Data

1608
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

Xenbase atp5b

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Atp5b interacts with 45 markers (Mir23a, Mir23b, Mir101c, ...) View All

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All Sequences

112
RefSeq

2
UniProt

1
CCDS

CCDS24259.1
UniGene

238973

			Length	Strain/Species	Flank
genomic	OTTMUSG00000023688	VEGA Gene Model \| MGI Sequence Detail	7119	C57BL/6J	± kb
transcript	OTTMUST00000057840	VEGA \| MGI Sequence Detail	1916	Not Applicable
polypeptide	OTTMUSP00000027963	VEGA \| MGI Sequence Detail	529	Not Applicable

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SNPs within 2kb

57 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000004454 ATP synthase subunit beta, mitochondrial
EC

3.6.3.14
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site

IPR004100 ATPase, F1 complex alpha/beta subunit, N-terminal domain

IPR005722 ATPase, F1 complex, beta subunit

IPR024034 ATPase, F1 complex beta subunit/V1 complex, C-terminal

IPR000793 ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 1610

cDNA 1608

Primer pair 2

Microarray probesets 2

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MGD-MRK-36378

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 10

Phenotypes 10
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:190206 Baris OR, et al., The mitochondrial electron transport chain is dispensable for proliferation and differentiation of epidermal progenitor cells. Stem Cells. 2011 Sep;29(9):1459-68

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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