Atp5f1b MGI Mouse Gene Detail - MGI:107801 - ATP synthase F1 subunit beta

Symbol

Atp5f1b
Name

ATP synthase F1 subunit beta
Synonyms

Atp5b

Feature Type

protein coding gene
IDs

MGI:107801
NCBI Gene: 11947
Alliance

gene page
Transcription Start Sites

10 TSS

Sequence Map

Chr10:127919176-127926257 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 76.39 cM
Mapping Data

2 experiments

SNPs within 2kb

233 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107801	protein coding gene	Chr10:127919142-127926260 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0017847	protein coding gene	Chr10:131758823-131766995 (+)
A/J	MGP_AJ_G0017822	protein coding gene	Chr10:126486771-126493889 (+)
AKR/J	MGP_AKRJ_G0017785	protein coding gene	Chr10:130217932-130225068 (+)
BALB/cJ	MGP_BALBcJ_G0017786	protein coding gene	Chr10:126870612-126878682 (+)
C3H/HeJ	MGP_C3HHeJ_G0017609	protein coding gene	Chr10:130371366-130379192 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018241	protein coding gene	Chr10:136244265-136251273 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015919	protein coding gene	Chr10:120451080-120457779 (+)
CAST/EiJ	MGP_CASTEiJ_G0017170	protein coding gene	Chr10:131073610-131080534 (+)
CBA/J	MGP_CBAJ_G0017579	protein coding gene	Chr10:141753971-141777104 (+)
DBA/2J	MGP_DBA2J_G0017685	protein coding gene	Chr10:125560898-125568320 (+)
FVB/NJ	MGP_FVBNJ_G0017680	protein coding gene	Chr10:124495252-124502290 (+)
LP/J	MGP_LPJ_G0017759	protein coding gene	Chr10:132374849-132381975 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017708	protein coding gene	Chr10:144361206-144368324 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018281	protein coding gene	Chr10:130301530-130309011 (+)
PWK/PhJ	MGP_PWKPhJ_G0016955	protein coding gene	Chr10:125811245-125818345 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0016744	protein coding gene	Chr10:129385313-129392283 (+)
WSB/EiJ	MGP_WSBEiJ_G0017229	protein coding gene	Chr10:130517806-130525475 (+)

Human Ortholog

ATP5F1B, ATP synthase F1 subunit beta

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ATP5F1B, ATP synthase F1 subunit beta
Synonyms

ATP5B, ATPMB, ATPSB, HEL-S-271, HUMOP2
Links

HGNC:830

NCBI Gene ID: 506

UniProt: P06576
Chr Location

12q13.3; chr12:56638175-56645984 (-) GRCh38

MGI Vertebrate Homology

Atp5f1b stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ATP5F1B
Protein SuperFamily

ATPase_subunit_beta
Gene Tree

Atp5f1b

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

30
Endonuclease-mediated

3
Gene trapped

22
Targeted

5
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

31 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

85
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

900
Tissues

138
cDNA Data

1609
Literature Summary

14

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase atp5f1b

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All Sequences

119
RefSeq

2
UniProt

1
CCDS

CCDS24259.1

Ensembl

ENSMUSG00000025393 (Evidence)
NCBI Gene

11947

			Length	Strain/Species	Flank
genomic	11947	NCBI Gene Model \| MGI Sequence Detail	7082	C57BL/6J	± kb
transcript	NM_016774	RefSeq \| MGI Sequence Detail	1879	C57BL/6
polypeptide	P56480	UniProt \| EBI \| MGI Sequence Detail	529	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000004454 ATP synthase subunit beta, mitochondrial

(term hierarchy)
EC

7.1.2.2
InterPro Domains

IPR003593 AAA+ ATPase domain

IPR050053 ATPase alpha/beta chains

IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site

IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain

IPR036121 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain superfamily

IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain

IPR024034 ATPase, F1/V1 complex, beta/alpha subunit, C-terminal

IPR005722 ATP synthase, F1 complex, beta subunit

IPR027417 P-loop containing nucleoside triphosphate hydrolase
GlyGen

P56480 4 sites, 1 O-linked glycan (3 sites)

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All nucleic 1612

cDNA 1609

Primer pair 3

Microarray probesets 2

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MGD-MRK-36378, MGI:7469633

Summaries

All 83

Developmental Gene Expression 14

Gene Ontology 19

Phenotypes 17
Earliest

J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
Latest

J:359001 Hu Y, et al., Mitochondrial MOF regulates energy metabolism in heart failure via ATP5B hyperacetylation. Cell Rep. 2024 Oct 22;43(10):114839

TSS for Atp5f1b:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr96319	Chr10:127919170-127919178 (+)	-2 bp
Tssr96322	Chr10:127921379-127921397 (+)	2,212 bp
Tssr96323	Chr10:127921900-127921966 (+)	2,757 bp
Tssr96324	Chr10:127922001-127922036 (+)	2,843 bp
Tssr96325	Chr10:127922161-127922175 (+)	2,992 bp
Tssr96326	Chr10:127922178-127922191 (+)	3,009 bp
Tssr96327	Chr10:127922194-127922218 (+)	3,030 bp
Tssr96328	Chr10:127922241-127922258 (+)	3,074 bp
Tssr96329	Chr10:127924182-127924234 (+)	5,032 bp
Tssr96330	Chr10:127924242-127924299 (+)	5,095 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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