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Atp5b Gene Detail
Summary
  • Symbol
    Atp5b
  • Name
    ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
  • Feature Type
    protein coding gene
  • IDs
    MGI:107801
    NCBI Gene: 11947
  • Gene Overview
    MyGene.info: ATP5B
Location & Maps
more
  • Sequence Map
    Chr10:128083273-128090391 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      7119 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 76.39 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ATP5B, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ATP5B, ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ATPMB, ATPSB, HEL-S-271
  • Links
    NCBI Gene ID: 506
    neXtProt AC: NX_P06576
    UniProt: P06576

  • Chr Location
    12q13.3; chr12:56638175-56646068 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    139
  • Tissues
    125
  • cDNA Data
    1608
  • Literature Summary
    8
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023688 VEGA Gene Model | MGI Sequence Detail 7119 C57BL/6J ±  kb
transcript OTTMUST00000057840 VEGA | MGI Sequence Detail 1916 Not Applicable  
polypeptide OTTMUSP00000027963 VEGA | MGI Sequence Detail 529 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    57 from dbSNP Build 142
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000004454 ATP synthase subunit beta, mitochondrial
    (term hierarchy)
  • EC
    3.6.3.14
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR020003 ATPase, alpha/beta subunit, nucleotide-binding domain, active site
    IPR004100 ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal domain
    IPR000194 ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding domain
    IPR024034 ATPase, F1/V1 complex, beta/alpha subunit, C-terminal
    IPR005722 ATP synthase, F1 complex, beta subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 1610
    cDNA 1608
    Primer pair 2

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36378
References
more
  • Summaries
    All 56
    Developmental Gene Expression 8
    Gene Ontology 12
    Phenotypes 11
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/11/2017
MGI 6.10 		The Jackson Laboratory