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Akr7a5 Gene Detail
Summary
  • Symbol
    Akr7a5
  • Name
    aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)
  • Synonyms
    0610025K21Rik, Afar
  • Feature Type
    protein coding gene
  • IDs
    MGI:107796
    NCBI Gene: 110198
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:139310744-139318426 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 70.64 cM, cytoband D3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107796
protein coding gene Chr4:139310701-139318786 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029015
protein coding gene Chr4:142136923-142145696 (+)
A/J MGP_AJ_G0028974
protein coding gene Chr4:136026139-136033646 (+)
AKR/J MGP_AKRJ_G0028926
protein coding gene Chr4:139922733-139930395 (+)
BALB/cJ MGP_BALBcJ_G0028998
protein coding gene Chr4:136702974-136710916 (+)
C3H/HeJ MGP_C3HHeJ_G0028712
protein coding gene Chr4:140302315-140310108 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029439
protein coding gene Chr4:147167249-147180006 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026710
protein coding gene Chr4:128999707-129007358 (+)
CAST/EiJ MGP_CASTEiJ_G0028144
protein coding gene Chr4:138481144-138490405 (+)
CBA/J MGP_CBAJ_G0028676
protein coding gene Chr4:151418174-151426441 (+)
DBA/2J MGP_DBA2J_G0028826
protein coding gene Chr4:136425399-136433064 (+)
FVB/NJ MGP_FVBNJ_G0028793
protein coding gene Chr4:135445789-135453792 (+)
LP/J MGP_LPJ_G0028925
protein coding gene Chr4:142211083-142218762 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028819
protein coding gene Chr4:155319180-155326857 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029477
protein coding gene Chr4:140450158-140459939 (+)
PWK/PhJ MGP_PWKPhJ_G0027865
protein coding gene Chr4:133273532-133281652 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027690
protein coding gene Chr4:136224030-136233387 (+)
WSB/EiJ MGP_WSBEiJ_G0028222
protein coding gene Chr4:140702984-140709506 (+)



Homology
more
  • Human Ortholog
    AKR7A2, aldo-keto reductase family 7 member A2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    AKR7A2, aldo-keto reductase family 7 member A2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AFAR, AFAR1, AFB1-AR1, AKR7
  • Links
    NCBI Gene ID: 8574
    neXtProt AC: NX_O43488
    UniProt: O43488

  • Chr Location
    1p36.13; chr1:19302708-19312146 (-)  GRCh38.p7

  • Human Ortholog
    AKR7A3, aldo-keto reductase family 7 member A3
    Orthology source: HGNC
  • Synonyms
    AFAR2
  • Links
    NCBI Gene ID: 22977
    neXtProt AC: NX_O95154
    UniProt: O95154

  • Chr Location
    1p36.13; chr1:19274309-19289362 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000028743 Ensembl Gene Model | MGI Sequence Detail 7683 C57BL/6J ±  kb
transcript ENSMUST00000073787 Ensembl | MGI Sequence Detail 1288 Not Applicable  
polypeptide ENSMUSP00000073459 Ensembl | MGI Sequence Detail 367 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 90
    cDNA 89
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36373, MGI:1913326
References
more
  • Summaries
    All 37
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
  • Latest
    J:151002 Pagliarini DJ, et al., A mitochondrial protein compendium elucidates complex I disease biology. Cell. 2008 Jul 11;134(1):112-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory