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Crmp1
Gene Detail
Symbol

Name
ID
Crmp1
collapsin response mediator protein 1
MGI:107793
STS
Synonyms
DRP-1, Ulip3
Feature Type
protein coding gene
Genetic Map
Chromosome 5
19.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:37241940-37292133 bp, + strand
From VEGA annotation of GRCm38

  50194 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CRMP1
Gene Tree: Crmp1

Human
homologs
CRMP1, collapsin response mediator protein 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1400
neXtProt AC: NX_Q14194

Human Synonyms: CRMP-1, DPYSL1, DRP1, DRP-1, ULIP-3

Human Chr (Location): 4p16.1; chr4:5820764-5893083 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Chemically induced (ENU)(1) Gene trapped(10) Radiation induced(2) Targeted(3)
Genomic Mutations involving Crmp1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele show transient postnatal changes in granule cell proliferation, apoptosis and migration in cerebellum and delayed radial migration of cortical neurons in cerebral cortex. Homozygotes for another knock-out allele show reduced LTP and impaired spatial learning.
 
Mutations Annotated to Human Diseases (2)    Phenotype Images(4)
Interactions
Crmp1 interacts with 137 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process axon guidance, microtubule cytoskeleton organization, ...
Component cytoplasm, cytoskeleton, ...
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (29)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
RT-PCR 3
cDNA source data(192)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase crmp1 ; ZFIN crmp1    NEW 
Molecular
reagents
All nucleic(195) cDNA(192) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000056097 (Evidence)
Ensembl Gene Model ENSMUSG00000029121 (Evidence)
Entrez Gene 12933 (Evidence)
UniGene 290995
DFCI TC1572681, TC1586043, TC1594348
DoTS DT.101318692, DT.532809, DT.97414461
NIA Mouse Gene Index U005520
PDB 1KCX
Consensus CDS Project CCDS39075.1, CCDS51481.1
International Mouse Phenotyping Consortium Status Crmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056097 VEGA Gene Model | MGI Sequence Detail 50194 C57BL/6J ±  kb
transcript OTTMUST00000138705 VEGA | MGI Sequence Detail 3051 Not Applicable 
polypeptide OTTMUSP00000072882 VEGA | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(54) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(363 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase-related
InterPro IPR030624 Dihydropyrimidinase-related protein 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000005889 dihydropyrimidinase-related protein 1
References
(Earliest) J:36973 Taketo MM, et al., Mapping of eight testis-specific genes to mouse chromosomes. Genomics. 1997 Nov 15;46(1):138-42
(Latest) J:180581 Yamashita N, et al., Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. J Neurosci. 2012 Jan 25;32(4):1360-1365
All references(51)
Other
accession IDs
MGD-MRK-36370

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory