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Crmp1
Gene Detail
 Symbol
Name
ID
Crmp1
collapsin response mediator protein 1
MGI:107793
STS D5Mit182
Synonyms DRP-1, Ulip3
Feature Type protein coding gene
Genetic Map
Chromosome 5
19.96 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr5:37242080-37292132 bp, + strand
From Ensembl annotation of GRCm38

  50053 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20347  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Crmp1

Human
homologs
Human Homolog CRMP1, collapsin response mediator protein 1
NCBI Gene ID 1400
neXtProt AC  NX_Q14194
Human Synonyms  CRMP-1, DPYSL1, DRP1, DRP-1, ULIP-3
Human Chr (Location)  4p16.1; chr4:5820764-5893083 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(1) Gene trapped(10) Radiation induced(1) Targeted(3)
Genomic Mutations involving Crmp1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele show transient postnatal changes in granule cell proliferation, apoptosis and migration in cerebellum and delayed radial migration of cortical neurons in cerebral cortex. Homozygotes for another knock-out allele show reduced LTP and impaired spatial learning.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Crmp1 interacts with 137 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process pyrimidine nucleobase catabolic process
Component cytoplasm, cytoskeleton, ...
Function hydrolase activity, hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (141)    Tissues (29)    Images (28)
Theiler Stages: 17, 20, 21, 23, 24, 25, 27, 28
Assay TypeResults
RNA in situ 138
RT-PCR 3
cDNA source data(192)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(195) cDNA(192) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000029121 (Evidence)
Entrez Gene12933 (Evidence)
UniGene290995
DFCITC1572681, TC1586043, TC1594348
DoTSDT.101318692, DT.532809, DT.97414461
NIA Mouse Gene IndexU005520
PDB1KCX
Consensus CDS ProjectCCDS39075.1, CCDS51481.1
International Mouse Knockout Project StatusCrmp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029121 Ensembl Gene Model | MGI Sequence Detail 50053 C57BL/6J ±  kb
transcript ENSMUST00000114158 Ensembl | MGI Sequence Detail 3049 Not Applicable 
polypeptide ENSMUSP00000109795 Ensembl | MGI Sequence Detail 686 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(5)
Polymorphisms RFLP(1) : SNPs within 2kb(361 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006680 Amidohydrolase 1
InterPro IPR011778 Hydantoinase/dihydropyrimidinase
InterPro IPR011059 Metal-dependent hydrolase, composite domain
Protein Ontology PR:000005889 dihydropyrimidinase-related protein 1
References (Earliest) J:36973 Taketo MM, et al., Mapping of eight testis-specific genes to mouse chromosomes. Genomics. 1997 Nov 15;46(1):138-42
(Latest) J:180581 Yamashita N, et al., Phosphorylation of CRMP2 (Collapsin Response Mediator Protein 2) Is Involved in Proper Dendritic Field Organization. J Neurosci. 2012 Jan 25;32(4):1360-1365
All references(51)
Other
accession IDs
MGD-MRK-36370

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory