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Mesp1
Gene Detail
Symbol

Name
ID
Mesp1
mesoderm posterior 1
MGI:107785
Synonyms
bHLHc5
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:79792241-79793788 bp, - strand
From VEGA annotation of GRCm38

  1548 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

HCOP human homology predictions: MESP1
Gene Tree: Mesp1

Human
homologs
MESP1, mesoderm posterior bHLH transcription factor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55897
neXtProt AC: NX_Q9BRJ9

Human Synonyms: bHLHc5

Human Chr (Location): 15q26.1; chr15:89749867-89751309 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(2) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations die by embryonic day 10.5 with growth retardation and heart defects.
 
Interactions
Mesp1 interacts with 34 markers (Mir1a-1, Mir1a-2, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (45 annotations)
Process cardiac atrium formation, cardiac cell fate determination, ...
Component nucleus
Function DNA binding, enhancer binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (211)    Tissues (113)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 138
In situ reporter (knock in) 72
RT-PCR 1
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(7) cDNA(26) Primer pair(2) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024965 (Evidence)
Ensembl Gene Model ENSMUSG00000030544 (Evidence)
Entrez Gene 17292 (Evidence)
UniGene 1404
DFCI TC1584351
DoTS DT.101703914
NIA Mouse Gene Index U028749
Consensus CDS Project CCDS21387.1
International Mouse Phenotyping Consortium Status Mesp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024965 VEGA Gene Model | MGI Sequence Detail 1548 C57BL/6J ±  kb
transcript OTTMUST00000061467 VEGA | MGI Sequence Detail 1275 Not Applicable 
polypeptide OTTMUSP00000030151 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(20) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(15 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Protein Ontology PR:000010332 mesoderm posterior protein 1
References
(Earliest) J:35774 Saga Y, et al., MesP1: a novel basic helix-loop-helix protein expressed in the nascent mesodermal cells during mouse gastrulation. Development. 1996 Sep;122(9):2769-78
(Latest) J:222738 Abboud N, et al., A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage. Nat Commun. 2015;6:6749
All references(131)
Other
accession IDs
MGD-MRK-36362

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory