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Mesp1 Gene Detail
Summary
  • Symbol
    Mesp1
  • Name
    mesoderm posterior 1
  • Synonyms
    bHLHc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107785
    NCBI Gene: 17292
  • Gene Overview
    MyGene.info: MESP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr7:79792241-79793788 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      1548 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 45.16 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    MESP1, mesoderm posterior bHLH transcription factor 1
  • Vertebrate Orthologs
    6
  • Human Ortholog
    MESP1, mesoderm posterior bHLH transcription factor 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bHLHc5
  • Links
    NCBI Gene ID: 55897
    neXtProt AC: NX_Q9BRJ9
    UniProt: Q9BRJ9

  • Chr Location
    15q26.1; chr15:89734772-89751309 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 4 alleles in 2 genetic backgrounds
    96 phenotypes from multigenic genotypes
    121 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die by embryonic day 10.5 with growth retardation and heart defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000024965 VEGA Gene Model | MGI Sequence Detail 1548 C57BL/6J ±  kb
    transcript OTTMUST00000061467 VEGA | MGI Sequence Detail 1275 Not Applicable  
    polypeptide OTTMUSP00000030151 VEGA | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      15 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 7
      cDNA 27
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36362
    References
    more
    • Summaries
      All 180
      Developmental Gene Expression 39
      Gene Ontology 8
      Phenotypes 121
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:260697 Lescroart F, et al., Defining the earliest step of cardiovascular lineage segregation by single-cell RNA-seq. Science. 2018 Mar 9;359(6380):1177-1181

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory