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Mesp1 Gene Detail
Summary
  • Symbol
    Mesp1
  • Name
    mesoderm posterior 1
  • Synonyms
    bHLHc5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107785
    NCBI Gene: 17292
  • Alliance
    genome feature page
  • Transcription Start Sites
    4 TSS
  • Regulated by
    Rr440 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr7:79441989-79443338 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.16 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    85 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107785
 protein coding gene Chr7:79441989-79443536 (-)
129S1/SvImJ ENSMUSG00200030218
 protein coding gene Chr7:66255667-66257214 (-)
A/J ENSMUSG00195013178
 protein coding gene Chr7:70670527-70672074 (-)
AKR/J ENSMUSG00220037408
 protein coding gene Chr7:64212544-64214091 (-)
BALB/cJ ENSMUSG00180012284
 protein coding gene Chr7:67395649-67397196 (-)
C3H/HeJ ENSMUSG00175021163
 protein coding gene Chr7:68167741-68169288 (-)
C57BL/6NJ ENSMUSG00215015118
 protein coding gene Chr7:67266868-67268415 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029887
 protein coding gene Chr7:82346857-82348420 (-)
CAST/EiJ ENSTCUG00005043255
 protein coding gene Chr7:70719631-70721178 (-)
CBA/J ENSMUSG00210023895
 protein coding gene Chr7:68019011-68020558 (-)
DBA/2J ENSMUSG00185040694
 protein coding gene Chr7:72341756-72343303 (-)
FVB/NJ ENSMUSG00205018858
 protein coding gene Chr7:67908302-67909849 (-)
JF1/MsJ ENSUMUG00000020104
 protein coding gene Chr7:77001563-77003110 (-)
LP/J ENSMUSG00230011083
 protein coding gene Chr7:78431338-78432885 (-)
NOD/ShiLtJ ENSMUSG00190016629
 protein coding gene Chr7:68160262-68161809 (-)
NZO/HlLtJ ENSMUSG00225041414
 protein coding gene Chr7:76672978-76674525 (-)
PWK/PhJ ENSLUMG00010016160
 protein coding gene Chr7:66596344-66597887 (-)
SPRET/EiJ ENSMSPG00010020419
 protein coding gene Chr7:67007008-67008542 (-)
WSB/EiJ ENSIUOG00005019189
 protein coding gene Chr7:68508445-68509992 (-)



Homology
more
  • Human Ortholog
    MESP1, mesoderm posterior bHLH transcription factor 1
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MESP1, mesoderm posterior bHLH transcription factor 1
  • Synonyms
    bHLHc5
  • Links
    NCBI Gene ID: 55897
    UniProt: Q9BRJ9

  • Chr Location
    15q26.1; chr15:89732446-89751249 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MESP1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 4 alleles in 2 genetic backgrounds
    126 phenotypes from multigenic genotypes
    197 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations die by embryonic day 10.5 with growth retardation and heart defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    871
  • Tissues
    118
  • cDNA Data
    29
  • Literature Summary
    53
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17292 NCBI Gene Model | MGI Sequence Detail 1350 C57BL/6J ±  kb
    transcript NM_008588 RefSeq | MGI Sequence Detail 1098 Not Specified  
    polypeptide P97309 UniProt | EBI | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 49
      Genomic 7
      cDNA 30
      Primer pair 7
      Other 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36362
    References
    more
    • Summaries
      All 277
      Developmental Gene Expression 53
      Gene Ontology 12
      Phenotypes 197
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:391330 Miura A, et al., Ectomesenchyme contributes to epidermal stem cell formation through mesenchymal-to-epithelial transition. Nat Commun. 2026 Jul 4;17(1)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory