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Apbb1
Gene Detail
 Symbol
Name
ID
Apbb1
amyloid beta (A4) precursor protein-binding, family B, member 1
MGI:107765
Synonyms Fe65, Rir
Feature Type protein coding gene
Genetic Map
Chromosome 7
55.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr7:105558486-105574402 bp, - strand
From Ensembl annotation of GRCm38

  15917 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Apbb1

Human
homologs
Human Homolog APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NCBI Gene ID 322
neXtProt AC  NX_O00213
Human Synonyms  FE65, MGC:9072, RIR
Human Chr (Location)  11p15; chr11:6395124-6419613 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Targeted(6)
 
Homozygotes for a null allele are hypersensitive to ionizing radiation while mouse embryonic fibroblasts are hypersensitive to DNA damaging agents. Homozygotes for a second null allele display impaired performance in learning and memory tasks, with a striking deficit in reversal spatial learning.
 
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process actin filament-based movement, apoptotic process, ...
Component cell projection, cytoplasm, ...
Function beta-amyloid binding, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (215)    Tissues (110)    Images (35)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 215
cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(13) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000037032 (Evidence)
Entrez Gene11785 (Evidence)
DFCITC1573997, TC1588669, TC1591584, TC1637256, TC1661904
DoTSDT.101736491, DT.101736492, DT.491464, DT.99864594
NIA Mouse Gene IndexU029038
International Mouse Knockout Project StatusApbb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000037032 Ensembl Gene Model | MGI Sequence Detail 15917 C57BL/6J ±  kb
transcript ENSMUST00000081165 Ensembl | MGI Sequence Detail 2530 Not Applicable 
polypeptide ENSMUSP00000079932 Ensembl | MGI Sequence Detail 710 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(24) UniProt(3)
Polymorphisms PCR(1) : SNPs within 2kb(43 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR001202 WW domain
Protein Ontology PR:000004118 amyloid beta A4 precursor protein-binding family B member 1
References (Earliest) J:37182 Simeone A, et al., Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives. Dev Neurosci. 1994;16(1-2):53-60
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(58)
Other
accession IDs
MGD-MRK-36342

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory