Apbb1
Gene Detail

Symbol Name ID

Apbb1 amyloid beta (A4) precursor protein-binding, family B, member 1 MGI:107765

Synonyms

Fe65, Rir

Feature Type

protein coding gene

Genetic Map

Chromosome 7

55.90 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr7:105558486-105574402 bp, - strand From Ensembl annotation of GRCm38   15917 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:898  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken

Gene Tree: Apbb1

Human homologs

Human Homolog		APBB1, amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
NCBI Gene ID		322
neXtProt AC		NX_O00213
Human Synonyms		FE65, MGC:9072, RIR
Human Chr (Location)		11p15; chr11:6416355-6440644 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygotes for a null allele are hypersensitive to ionizing radiation while mouse embryonic fibroblasts are hypersensitive to DNA damaging agents. Homozygotes for a second null allele display impaired performance in learning and memory tasks, with a striking deficit in reversal spatial learning.

 

Gene Ontology (GO) classifications

All GO classifications: (59 annotations)

Process	actin filament-based movement, apoptotic process, ...
Component	cell projection, cytoplasm, ...
Function	beta-amyloid binding, chromatin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (215)    Tissues (110)    Images (35)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	215

cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(111) cDNA(110) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000037032 (Evidence)
Entrez Gene	11785 (Evidence)
UniGene	38469
DFCI	TC1573997, TC1588669, TC1591584, TC1637256, TC1661904
DoTS	DT.101736491, DT.101736492, DT.491464, DT.99864594
NIA Mouse Gene Index	U029038
International Mouse Knockout Project Status	Apbb1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000037032	Ensembl Gene Model | MGI Sequence Detail	15917	C57BL/6J
transcript	ENSMUST00000081165	Ensembl | MGI Sequence Detail	2530	Not Applicable
polypeptide	ENSMUSP00000079932	Ensembl | MGI Sequence Detail	710	Not Applicable

All sequences(42) RefSeq(8) UniProt(3)

Polymorphisms

PCR(1) : SNPs(38 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006020	Phosphotyrosine interaction domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR001202	WW/Rsp5/WWP
Protein Ontology	PR:000004118	amyloid beta A4 precursor protein-binding family B member 1

References

(Earliest) J:37182 Simeone A, et al., Expression of the neuron-specific FE65 gene marks the development of embryo ganglionic derivatives. Dev Neurosci. 1994;16(1-2):53-60
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(59)

Other accession IDs

MGD-MRK-36342